دورية أكاديمية

Entry receptors - the gateway to alphavirus infection.

التفاصيل البيبلوغرافية
العنوان: Entry receptors - the gateway to alphavirus infection.
المؤلفون: Zimmerman O; Department of Medicine., Holmes AC; Department of Medicine., Kafai NM; Department of Medicine.; Department of Pathology and Immunology., Adams LJ; Department of Pathology and Immunology., Diamond MS; Department of Medicine.; Department of Pathology and Immunology.; Department of Molecular Microbiology, and.; The Andrew M. and Jane M. Bursky Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine, St. Louis, Missouri, USA.
المصدر: The Journal of clinical investigation [J Clin Invest] 2023 Jan 17; Vol. 133 (2). Date of Electronic Publication: 2023 Jan 17.
نوع المنشور: Journal Article; Review; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
اللغة: English
بيانات الدورية: Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 7802877 Publication Model: Electronic Cited Medium: Internet ISSN: 1558-8238 (Electronic) Linking ISSN: 00219738 NLM ISO Abbreviation: J Clin Invest Subsets: MEDLINE
أسماء مطبوعة: Publication: 1999- : Ann Arbor, MI : American Society for Clinical Investigation
Original Publication: New Haven [etc.] American Society for Clinical Investigation.
مواضيع طبية MeSH: Alphavirus Infections* , Alphavirus*/genetics, Animals ; Humans
مستخلص: Alphaviruses are enveloped, insect-transmitted, positive-sense RNA viruses that infect humans and other animals and cause a range of clinical manifestations, including arthritis, musculoskeletal disease, meningitis, encephalitis, and death. Over the past four years, aided by CRISPR/Cas9-based genetic screening approaches, intensive research efforts have focused on identifying entry receptors for alphaviruses to better understand the basis for cellular and species tropism. Herein, we review approaches to alphavirus receptor identification and how these were used for discovery. The identification of new receptors advances our understanding of viral pathogenesis, tropism, and evolution and is expected to contribute to the development of novel strategies for prevention and treatment of alphavirus infection.
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معلومات مُعتمدة: R01 AI014367 United States AI NIAID NIH HHS; R01 AI164653 United States AI NIAID NIH HHS; United States HHMI Howard Hughes Medical Institute; F30 AI164842 United States AI NIAID NIH HHS; R01 AI143673 United States AI NIAID NIH HHS; U19 AI142790 United States AI NIAID NIH HHS
تواريخ الأحداث: Date Created: 20230117 Date Completed: 20230118 Latest Revision: 20230812
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC9843064
DOI: 10.1172/JCI165307
PMID: 36647825
قاعدة البيانات: MEDLINE
الوصف
تدمد:1558-8238
DOI:10.1172/JCI165307