دورية أكاديمية
أعرض في EDS

Exploring the Validity of Available Markers and Indices in the Diagnosis of Nonalcoholic Fatty Liver Disease (NAFLD) in People with Type 2 Diabetes in Saudi Arabia.

التفاصيل البيبلوغرافية
العنوان: Exploring the Validity of Available Markers and Indices in the Diagnosis of Nonalcoholic Fatty Liver Disease (NAFLD) in People with Type 2 Diabetes in Saudi Arabia.
المؤلفون: Ajabnoor GMA; Department of Clinical Biochemistry, Faculty of Medicine, King Abdulaziz University, Jeddah 21551, Saudi Arabia.; Saudi Diabetes Research Group, Deanship of Scientific Research, King Abdulaziz University, Jeddah 3270, Saudi Arabia.; Food, Nutrition and Lifestyle Unit, King Fahd Medical Research Centre, King Abdulaziz University, Jeddah 3270, Saudi Arabia., Bahijri SM; Department of Clinical Biochemistry, Faculty of Medicine, King Abdulaziz University, Jeddah 21551, Saudi Arabia.; Saudi Diabetes Research Group, Deanship of Scientific Research, King Abdulaziz University, Jeddah 3270, Saudi Arabia.; Food, Nutrition and Lifestyle Unit, King Fahd Medical Research Centre, King Abdulaziz University, Jeddah 3270, Saudi Arabia., Enani SM; Saudi Diabetes Research Group, Deanship of Scientific Research, King Abdulaziz University, Jeddah 3270, Saudi Arabia.; Food, Nutrition and Lifestyle Unit, King Fahd Medical Research Centre, King Abdulaziz University, Jeddah 3270, Saudi Arabia.; Department of Food and Nutrition, Faculty of Human Sciences and Design, King Abdulaziz University, Jeddah 3270, Saudi Arabia., Alsheikh L; Saudi Diabetes Research Group, Deanship of Scientific Research, King Abdulaziz University, Jeddah 3270, Saudi Arabia.; Food, Nutrition and Lifestyle Unit, King Fahd Medical Research Centre, King Abdulaziz University, Jeddah 3270, Saudi Arabia.; Department of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia., Ahmed M; Saudi Diabetes Research Group, Deanship of Scientific Research, King Abdulaziz University, Jeddah 3270, Saudi Arabia.; Department of Internal Medicine, Faculty of Medicine, King Abdulaziz University Hospital, King Abdulaziz University, Jeddah 21551, Saudi Arabia., Alhozali A; Saudi Diabetes Research Group, Deanship of Scientific Research, King Abdulaziz University, Jeddah 3270, Saudi Arabia.; Department of Internal Medicine, Faculty of Medicine, King Abdulaziz University Hospital, King Abdulaziz University, Jeddah 21551, Saudi Arabia., Al-Shali K; Saudi Diabetes Research Group, Deanship of Scientific Research, King Abdulaziz University, Jeddah 3270, Saudi Arabia.; Department of Internal Medicine, Faculty of Medicine, King Abdulaziz University Hospital, King Abdulaziz University, Jeddah 21551, Saudi Arabia., Eldakhakhny BM; Department of Clinical Biochemistry, Faculty of Medicine, King Abdulaziz University, Jeddah 21551, Saudi Arabia.; Saudi Diabetes Research Group, Deanship of Scientific Research, King Abdulaziz University, Jeddah 3270, Saudi Arabia.; Food, Nutrition and Lifestyle Unit, King Fahd Medical Research Centre, King Abdulaziz University, Jeddah 3270, Saudi Arabia., Alamoudi AA; Department of Clinical Biochemistry, Faculty of Medicine, King Abdulaziz University, Jeddah 21551, Saudi Arabia.; Saudi Diabetes Research Group, Deanship of Scientific Research, King Abdulaziz University, Jeddah 3270, Saudi Arabia., Al-Ahmadi J; Saudi Diabetes Research Group, Deanship of Scientific Research, King Abdulaziz University, Jeddah 3270, Saudi Arabia.; Food, Nutrition and Lifestyle Unit, King Fahd Medical Research Centre, King Abdulaziz University, Jeddah 3270, Saudi Arabia.; Department of Family Medicine, Faculty of Medicine, King Abdulaziz University, Jeddah 21551, Saudi Arabia., Borai A; Saudi Diabetes Research Group, Deanship of Scientific Research, King Abdulaziz University, Jeddah 3270, Saudi Arabia.; King Abdullah International Medical Research Center, King Saud Bin Abdulaziz University for Health Sciences, King Abdulaziz Medical City, Jeddah 9515, Saudi Arabia., Al-Mowallad AS; Department of Clinical Biochemistry, Faculty of Medicine, King Abdulaziz University, Jeddah 21551, Saudi Arabia., Tuomilehto J; Saudi Diabetes Research Group, Deanship of Scientific Research, King Abdulaziz University, Jeddah 3270, Saudi Arabia.; Department of Public Health, University of Helsinki, FI-00014 Helsinki, Finland.; Public Health Promotion Unit, Finnish Institute for Health and Welfare, FI-00271 Helsinki, Finland.
المصدر: Diseases (Basel, Switzerland) [Diseases] 2023 Jan 15; Vol. 11 (1). Date of Electronic Publication: 2023 Jan 15.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101636232 Publication Model: Electronic Cited Medium: Print ISSN: 2079-9721 (Print) Linking ISSN: 20799721 NLM ISO Abbreviation: Diseases Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI AG, [2013]-
مستخلص: Nonalcoholic fatty liver disease (NAFLD) is common among Saudi patients with type 2 diabetes (T2DM). However, recommended clinical procedures to detect it are unavailable in many locations. Therefore, better and more available diagnostic biomarkers for NAFLD are needed. Various serum parameters were suggested, and algorithms that employ routine measurements in clinical practice have been developed for the prediction of fat stores in the liver in different populations. However, no such studies have been conducted on Saudis. We aimed to compare selected biochemical markers and calculated indices in T2DM patients diagnosed with NAFLD and patients without NAFLD to find the best markers associated with NAFLD. A cross-sectional study was employed to recruit 67 people with T2DM from endocrine outpatient clinics at King Abdul-Aziz University Hospital. NAFLD was detected by ultrasonography in 28 patients. Demographic information, anthropometric, and blood pressure (BP) measurements were taken. Fasting blood samples were obtained to measure glucose, glycated haemoglobin, lipid profile, liver function tests, and highly sensitive C-reactive protein. Fatty liver index, hepatic steatosis index, NAFLD-liver fat score, and triglyceride and glucose index were calculated. Following stepwise forward likelihood ratio regression with independent variables included in one model using binary logistic regression with age and waist circumference (WC) entered as covariates, elevated diastolic BP and low high-density lipoprotein- cholesterol remained significantly associated with NAFLD ( p = 0.002 and 0.03, respectively). However, none of the investigated indices could be used to diagnose the disease adequately due to low specificity, even after calculating new cut-off values. Investigating novel markers and adjusting existing equations used to calculate indices to improve sensitivity and specificity in our population is needed.
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معلومات مُعتمدة: program for postgraduate students King Abdulaziz City for Science and Technology
فهرسة مساهمة: Keywords: NAFLD-liver fat score; fatty liver index; hepatic steatosis index; nonalcoholic fatty liver disease; triglyceride and glucose index; type 2 diabetes Saudis
تواريخ الأحداث: Date Created: 20230117 Latest Revision: 20230202
رمز التحديث: 20230202
مُعرف محوري في PubMed: PMC9887592
DOI: 10.3390/diseases11010010
PMID: 36648875
قاعدة البيانات: MEDLINE
الوصف
تدمد:2079-9721
DOI:10.3390/diseases11010010