دورية أكاديمية
Src homology 2-B adapter protein 3 C784 T and Methylenetetrahydrofolate reductase C677 T Polymorphisms and Inflammation Markers in ST-segment Elevation Myocardial Infarction Patients.
| العنوان: | Src homology 2-B adapter protein 3 C784 T and Methylenetetrahydrofolate reductase C677 T Polymorphisms and Inflammation Markers in ST-segment Elevation Myocardial Infarction Patients. |
|---|---|
| المؤلفون: | Golestani A; Student Research Committee, Birjand University of Medical Sciences, Birjand, Iran., Rahimi A; Student Research Committee, Birjand University of Medical Sciences, Birjand, Iran., Moezi Bady SA; Cardiovascular Diseases Research Center, Birjand University of Medical Sciences, Birjand, Iran., Azdaki N; Cardiovascular Diseases Research Center, Birjand University of Medical Sciences, Birjand, Iran., Sajjadi SM; Cellular and Molecular Research Center, Birjand University of Medical Sciences, Birjand, Iran. |
| المصدر: | Angiology [Angiology] 2024 Mar; Vol. 75 (3), pp. 281-287. Date of Electronic Publication: 2023 Jan 17. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Sage Publications Country of Publication: United States NLM ID: 0203706 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1940-1574 (Electronic) Linking ISSN: 00033197 NLM ISO Abbreviation: Angiology Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Thousand Oaks, CA : Sage Publications Original Publication: New York [etc.] Angiology Research Foundation. |
| مواضيع طبية MeSH: | ST Elevation Myocardial Infarction* , Myocardial Infarction*/diagnosis , Myocardial Infarction*/genetics , Coronary Artery Disease*/genetics, Humans ; Methylenetetrahydrofolate Reductase (NADPH2)/genetics ; Inflammation ; Polymorphism, Single Nucleotide |
| مستخلص: | Neutrophil-lymphocyte (NLR), platelet-lymphocyte (PLR), eosinophil-lymphocyte (ELR), and monocyte-lymphocyte (MLR) ratios are systemic inflammatory markers related to myocardial infarction. The aim of this study is to investigate the association of Src homology 2-B adapter protein 3 (SH2B3) C784 T and methylenetetrahydrofolate reductase (MTHFR) C677 T polymorphisms (SNP) with systemic inflammatory markers and the severity of coronary artery disease (CAD) in 150 ST-elevation myocardial infarction (STEMI) patients. Single nucleotide polymorphisms were genotyped using the tetra-primer amplification refractory mutation system-polymerase chain reaction (T-ARMS-PCR) method. The inflammatory markers were calculated. An interventional cardiologist blinded to other data assessed the SYNTAX (SX) Score. Eosinophil and platelet counts were significantly higher in SH2B3 variants than in the wild type. Additionally, SH2B3 variants had significantly higher ELR than the wild type (.12 ± .19 vs .25 ± .34, p = .018). NLR, PLR, ELR, and MLR were considerably higher in MTHFR variants than in the wild type ( p < .05). The SX score was significantly higher in both SH2B3 C784 T (21.24 ± 8.90 vs 15.29 ± 9.40, p = .00) and MTHFR C677 T (20.34 ± 10.21 vs 16.08 ± 8.39, p = .00) variants when compared with wild type. In conclusion, these polymorphisms are associated with several markers of systemic inflammation as well as the severity of CAD. Competing Interests: Declaration of Conflicting InterestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. Data AvailabilityThe datasets used and/or analyzed during the present study are available from the corresponding author on reasonable request. |
| فهرسة مساهمة: | Keywords: MTHFR; SH2B3; ST elevation myocardial infarction; inflammatory markers |
| المشرفين على المادة: | EC 1.5.1.20 (Methylenetetrahydrofolate Reductase (NADPH2)) |
| تواريخ الأحداث: | Date Created: 20230117 Date Completed: 20240118 Latest Revision: 20240118 |
| رمز التحديث: | 20240118 |
| DOI: | 10.1177/00033197231152693 |
| PMID: | 36650025 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1940-1574 |
|---|---|
| DOI: | 10.1177/00033197231152693 |