دورية أكاديمية
أعرض في EDS

Concentrations of total, bioavailable, and free 25OHD in individuals with and without primary hyperparathyroidism and their correlations to DXA and trabecular bone score.

التفاصيل البيبلوغرافية
العنوان: Concentrations of total, bioavailable, and free 25OHD in individuals with and without primary hyperparathyroidism and their correlations to DXA and trabecular bone score.
المؤلفون: Santos LM; Universidade Federal de São Paulo, Escola Paulista de Medicina, São Paulo, SP, Brasil, li_fameca@yahoo.com.br., Ohe M; Universidade Federal de São Paulo, Escola Paulista de Medicina, São Paulo, SP, Brasil., Pallone S; Universidade Federal de São Paulo, Escola Paulista de Medicina, São Paulo, SP, Brasil., Nacaguma I; Universidade Federal de São Paulo, Escola Paulista de Medicina, São Paulo, SP, Brasil., Kunii I; Universidade Federal de São Paulo, Escola Paulista de Medicina, São Paulo, SP, Brasil., Silva R; Universidade Federal de São Paulo, Escola Paulista de Medicina, São Paulo, SP, Brasil., Brandão CM; Universidade Federal de São Paulo, Escola Paulista de Medicina, São Paulo, SP, Brasil., Vieira JG; Universidade Federal de São Paulo, Escola Paulista de Medicina, São Paulo, SP, Brasil., Lazaretti-Castro M; Universidade Federal de São Paulo, Escola Paulista de Medicina, São Paulo, SP, Brasil.
المصدر: Archives of endocrinology and metabolism [Arch Endocrinol Metab] 2023 Mar 10; Vol. 67 (2), pp. 242-250. Date of Electronic Publication: 2023 Jan 17.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Segmento Farma Editores Country of Publication: Brazil NLM ID: 101652058 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2359-4292 (Electronic) Linking ISSN: 23593997 NLM ISO Abbreviation: Arch Endocrinol Metab Subsets: MEDLINE
أسماء مطبوعة: Original Publication: São Paulo, SP : Segmento Farma Editores
مواضيع طبية MeSH: Cancellous Bone* , Hyperparathyroidism, Primary*, Humans ; Absorptiometry, Photon ; Cross-Sectional Studies ; Bone Density ; Vitamin D
مستخلص: Objective: This study aimed to investigate the association between 25OHD (total, bioavailable and free) with bone mass and microarchitecture among primary hyperparathyroidism (PHPT) patients and controls.
Subjects and Methods: Sixty-four patients in the preoperative period of PHPT and 63 matched controls, who had not taken vitamin D in the last three months. To calculate the bioavailable and free 25OHD, the genetic variants of the vitamin D-binding protein (DBP) were determined. Bone mineral density (BMD) was determined by dual-energy X-ray absorptiometry (DXA). The distributions of total, bioavailable and free 25OHD and their correlation with TBS and DXA were evaluated.
Results: PHPT showed BMD and TBS values lower than CTRL in all locations (p < 0.05). There were no statistical differences in the levels of free, bioavailable and total 25OHD between the PHPT and CTRL groups [mean, min-max: 3.4 (1.4-8.6) vs. 3.1 (1.0- 9.8) pg/mL, 1.51 (0.43-3.58) vs. 1.41 (0.38-3.48) ng/mL, 22.6 (11.0-39.9) vs. 20.6 (8.9-35.3) ng/dL, respectively; (p > 0.05). The distribution of DBP haplotypes was similar between groups. DXA showed no correlation with any form of 25OHD in both groups. TBS presented a weak correlation with the total 25OHD in PHPT (r = 0.28; p = 0.02) and a moderate correlation with the total, free and bioavailable 25OHD in CTRL (r = 0.42; r = 0.42; r = 0.43; respectively, p < 0.01).
Conclusion: The concentrations of total, free and bioavailable 25OHD were similar in both the PHPT and control groups. 25OHD concentrations correlated positively with TBS and not with DXA, especially in controls, suggesting that this method may be more sensitive to assessing the consequences of vitamin D deficiency on bone quality in individuals without PHPT.
References: Eur J Endocrinol. 2006 Aug;155(2):237-44. (PMID: 16868136)
J Bone Miner Res. 2002 Nov;17 Suppl 2:N75-80. (PMID: 12412781)
Endocrinology. 1989 Feb;124(2):649-54. (PMID: 2463902)
J Clin Endocrinol Metab. 1986 Oct;63(4):954-9. (PMID: 3745408)
J Clin Densitom. 2018 Jul - Sep;21(3):453-458. (PMID: 29657024)
J Bone Miner Res. 1989 Jun;4(3):283-91. (PMID: 2763869)
J Bone Miner Res. 2014 Mar;29(3):518-30. (PMID: 24443324)
Front Endocrinol (Lausanne). 2019 May 28;10:317. (PMID: 31191450)
Int J Endocrinol. 2014;2014:981581. (PMID: 24868205)
Semin Arthritis Rheum. 2009 Jun;38(6):444-51. (PMID: 18336870)
Osteoporos Int. 2012 Feb;23(2):675-86. (PMID: 21625888)
Pediatr Neonatol. 2019 Jun;60(3):237-244. (PMID: 31101452)
Am J Clin Nutr. 2017 Jul;106(1):276-283. (PMID: 28592609)
PLoS One. 2019 Dec 12;14(12):e0226215. (PMID: 31830090)
J Clin Endocrinol Metab. 2015 Sep;100(9):3443-51. (PMID: 26079779)
Int J Endocrinol. 2018 Sep 18;2018:6282687. (PMID: 30363962)
J Endocrinol Invest. 2006 Jun;29(6):511-5. (PMID: 16840828)
Endocr Rev. 2019 Aug 1;40(4):1109-1151. (PMID: 30321335)
Int J Endocrinol. 2014;2014:561214. (PMID: 24987416)
J Clin Endocrinol Metab. 2016 Mar;101(3):905-13. (PMID: 26745256)
Endocrine. 2017 Jan;55(1):266-272. (PMID: 27154872)
Front Endocrinol (Lausanne). 2019 Mar 27;10:171. (PMID: 30972023)
Ann Intern Med. 2008 Aug 19;149(4):242-50. (PMID: 18711154)
Endocr Pract. 2017 May;23(5):605-613. (PMID: 28095044)
J Clin Densitom. 2019 Apr - Jun;22(2):162-170. (PMID: 30093271)
Endocrine. 2017 Jan;55(1):256-265. (PMID: 27033542)
Arch Endocrinol Metab. 2019 Jul 29;63(4):394-401. (PMID: 31365627)
Endocr Pract. 2017 Jan;23(1):66-71. (PMID: 27682354)
J Bone Miner Res. 2011 Nov;26(11):2762-9. (PMID: 21887701)
J Bone Miner Res. 2016 May;31(5):940-8. (PMID: 26498132)
Bone. 2013 Mar;53(1):154-9. (PMID: 23228370)
J Bone Miner Res. 2009 Apr;24(4):693-701. (PMID: 19049341)
Am J Clin Nutr. 2002 Dec;76(6):1446-53. (PMID: 12450915)
J Clin Endocrinol Metab. 2000 Mar;85(3):1054-8. (PMID: 10720039)
Bone. 2007 Mar;40(3):716-22. (PMID: 17112798)
PLoS One. 2012;7(7):e40090. (PMID: 22768331)
Arq Bras Endocrinol Metabol. 2012 Dec;56(9):618-26. (PMID: 23329184)
Rev Bras Ortop. 2013 Aug 13;48(3):228-235. (PMID: 31214537)
Braz J Med Biol Res. 2007 Apr;40(4):519-26. (PMID: 17401495)
Osteoporos Int. 2017 Jan;28(1):1-19. (PMID: 27613721)
Clin Endocrinol (Oxf). 2005 Nov;63(5):506-13. (PMID: 16268801)
فهرسة مساهمة: Keywords: 25-hydroxyvitamin D; DBP polymorphism; bone mineral density; trabecular bone score
المشرفين على المادة: 1406-16-2 (Vitamin D)
تواريخ الأحداث: Date Created: 20230118 Date Completed: 20230315 Latest Revision: 20231202
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC10689035
DOI: 10.20945/2359-3997000000529
PMID: 36651703
قاعدة البيانات: MEDLINE
الوصف
تدمد:2359-4292
DOI:10.20945/2359-3997000000529