دورية أكاديمية
Concentrations of total, bioavailable, and free 25OHD in individuals with and without primary hyperparathyroidism and their correlations to DXA and trabecular bone score.
العنوان: | Concentrations of total, bioavailable, and free 25OHD in individuals with and without primary hyperparathyroidism and their correlations to DXA and trabecular bone score. |
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المؤلفون: | Santos LM; Universidade Federal de São Paulo, Escola Paulista de Medicina, São Paulo, SP, Brasil, li_fameca@yahoo.com.br., Ohe M; Universidade Federal de São Paulo, Escola Paulista de Medicina, São Paulo, SP, Brasil., Pallone S; Universidade Federal de São Paulo, Escola Paulista de Medicina, São Paulo, SP, Brasil., Nacaguma I; Universidade Federal de São Paulo, Escola Paulista de Medicina, São Paulo, SP, Brasil., Kunii I; Universidade Federal de São Paulo, Escola Paulista de Medicina, São Paulo, SP, Brasil., Silva R; Universidade Federal de São Paulo, Escola Paulista de Medicina, São Paulo, SP, Brasil., Brandão CM; Universidade Federal de São Paulo, Escola Paulista de Medicina, São Paulo, SP, Brasil., Vieira JG; Universidade Federal de São Paulo, Escola Paulista de Medicina, São Paulo, SP, Brasil., Lazaretti-Castro M; Universidade Federal de São Paulo, Escola Paulista de Medicina, São Paulo, SP, Brasil. |
المصدر: | Archives of endocrinology and metabolism [Arch Endocrinol Metab] 2023 Mar 10; Vol. 67 (2), pp. 242-250. Date of Electronic Publication: 2023 Jan 17. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Segmento Farma Editores Country of Publication: Brazil NLM ID: 101652058 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2359-4292 (Electronic) Linking ISSN: 23593997 NLM ISO Abbreviation: Arch Endocrinol Metab Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: São Paulo, SP : Segmento Farma Editores |
مواضيع طبية MeSH: | Cancellous Bone* , Hyperparathyroidism, Primary*, Humans ; Absorptiometry, Photon ; Cross-Sectional Studies ; Bone Density ; Vitamin D |
مستخلص: | Objective: This study aimed to investigate the association between 25OHD (total, bioavailable and free) with bone mass and microarchitecture among primary hyperparathyroidism (PHPT) patients and controls. Subjects and Methods: Sixty-four patients in the preoperative period of PHPT and 63 matched controls, who had not taken vitamin D in the last three months. To calculate the bioavailable and free 25OHD, the genetic variants of the vitamin D-binding protein (DBP) were determined. Bone mineral density (BMD) was determined by dual-energy X-ray absorptiometry (DXA). The distributions of total, bioavailable and free 25OHD and their correlation with TBS and DXA were evaluated. Results: PHPT showed BMD and TBS values lower than CTRL in all locations (p < 0.05). There were no statistical differences in the levels of free, bioavailable and total 25OHD between the PHPT and CTRL groups [mean, min-max: 3.4 (1.4-8.6) vs. 3.1 (1.0- 9.8) pg/mL, 1.51 (0.43-3.58) vs. 1.41 (0.38-3.48) ng/mL, 22.6 (11.0-39.9) vs. 20.6 (8.9-35.3) ng/dL, respectively; (p > 0.05). The distribution of DBP haplotypes was similar between groups. DXA showed no correlation with any form of 25OHD in both groups. TBS presented a weak correlation with the total 25OHD in PHPT (r = 0.28; p = 0.02) and a moderate correlation with the total, free and bioavailable 25OHD in CTRL (r = 0.42; r = 0.42; r = 0.43; respectively, p < 0.01). Conclusion: The concentrations of total, free and bioavailable 25OHD were similar in both the PHPT and control groups. 25OHD concentrations correlated positively with TBS and not with DXA, especially in controls, suggesting that this method may be more sensitive to assessing the consequences of vitamin D deficiency on bone quality in individuals without PHPT. |
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فهرسة مساهمة: | Keywords: 25-hydroxyvitamin D; DBP polymorphism; bone mineral density; trabecular bone score |
المشرفين على المادة: | 1406-16-2 (Vitamin D) |
تواريخ الأحداث: | Date Created: 20230118 Date Completed: 20230315 Latest Revision: 20231202 |
رمز التحديث: | 20231215 |
مُعرف محوري في PubMed: | PMC10689035 |
DOI: | 10.20945/2359-3997000000529 |
PMID: | 36651703 |
قاعدة البيانات: | MEDLINE |
تدمد: | 2359-4292 |
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DOI: | 10.20945/2359-3997000000529 |