دورية أكاديمية
أعرض في EDS

IFN-stimulated metabolite transporter ENT3 facilitates viral genome release.

التفاصيل البيبلوغرافية
العنوان: IFN-stimulated metabolite transporter ENT3 facilitates viral genome release.
المؤلفون: Hsieh YT; Institute of Microbiology and Immunology, National Yang Ming Chiao Tung University, Taipei, Taiwan., Tsai TL; Institute of Microbiology and Immunology, National Yang Ming Chiao Tung University, Taipei, Taiwan.; Taiwan International Graduate Program in Molecular Medicine, National Yang Ming Chiao Tung University and Academia Sinica, Taipei, Taiwan., Huang SY; Institute of Microbiology and Immunology, National Yang Ming Chiao Tung University, Taipei, Taiwan., Heng JW; Institute of Microbiology and Immunology, National Yang Ming Chiao Tung University, Taipei, Taiwan., Huang YC; Institute of Microbiology and Immunology, National Yang Ming Chiao Tung University, Taipei, Taiwan., Tsai PY; Institute of Microbiology and Immunology, National Yang Ming Chiao Tung University, Taipei, Taiwan., Tu CC; Institute of Microbiology and Immunology, National Yang Ming Chiao Tung University, Taipei, Taiwan., Chao TL; Genomics Research Center, Academia Sinica, Taipei, Taiwan., Tsai YM; Department of Clinical Laboratory Sciences and Medical Biotechnology, National Taiwan University College of Medicine, Taipei, Taiwan., Chang PC; Institute of Microbiology and Immunology, National Yang Ming Chiao Tung University, Taipei, Taiwan., Lee CK; Graduate Institute of Immunology, College of Medicine, National Taiwan University, Taipei, Taiwan., Yu GY; National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Miaoli, Taiwan., Chang SY; Department of Clinical Laboratory Sciences and Medical Biotechnology, National Taiwan University College of Medicine, Taipei, Taiwan.; Department of Laboratory Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan., Dzhagalov IL; Institute of Microbiology and Immunology, National Yang Ming Chiao Tung University, Taipei, Taiwan., Hsu CL; Institute of Microbiology and Immunology, National Yang Ming Chiao Tung University, Taipei, Taiwan.; Taiwan International Graduate Program in Molecular Medicine, National Yang Ming Chiao Tung University and Academia Sinica, Taipei, Taiwan.
المصدر: EMBO reports [EMBO Rep] 2023 Mar 06; Vol. 24 (3), pp. e55286. Date of Electronic Publication: 2023 Jan 18.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 100963049 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1469-3178 (Electronic) Linking ISSN: 1469221X NLM ISO Abbreviation: EMBO Rep Subsets: MEDLINE
أسماء مطبوعة: Publication: 2024- : [London] : Nature Publishing Group
Original Publication: Oxford, UK : Published for EMBO by Oxford University Press, 2000-
مواضيع طبية MeSH: SARS-CoV-2*/genetics , COVID-19*, Humans ; Interferons/metabolism ; Membrane Transport Proteins/genetics ; Immunity, Innate ; Genome, Viral ; Nucleoside Transport Proteins/genetics ; Nucleoside Transport Proteins/metabolism
مستخلص: An increasing amount of evidence emphasizes the role of metabolic reprogramming in immune cells to fight infections. However, little is known about the regulation of metabolite transporters that facilitate and support metabolic demands. In this study, we found that the expression of equilibrative nucleoside transporter 3 (ENT3, encoded by solute carrier family 29 member 3, Slc29a3) is part of the innate immune response, which is rapidly upregulated upon pathogen invasion. The transcription of Slc29a3 is directly regulated by type I interferon-induced signaling, demonstrating that this metabolite transporter is an interferon-stimulated gene (ISG). Suprisingly, we unveil that several viruses, including SARS-CoV-2, require ENT3 to facilitate their entry into the cytoplasm. The removal or suppression of Slc29a3 expression is sufficient to significantly decrease viral replication in vitro and in vivo. Our study reveals that ENT3 is a pro-viral ISG co-opted by some viruses to gain a survival advantage.
(© 2023 The Authors. Published under the terms of the CC BY NC ND 4.0 license.)
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فهرسة مساهمة: Keywords: equilibrative nucleoside transporter; interferon-stimulated gene; macrophage; metabolite transporter; viral replication
سلسلة جزيئية: GEO GSE216974
المشرفين على المادة: 9008-11-1 (Interferons)
0 (Membrane Transport Proteins)
0 (SLC29A3 protein, human)
0 (Nucleoside Transport Proteins)
تواريخ الأحداث: Date Created: 20230118 Date Completed: 20230307 Latest Revision: 20230322
رمز التحديث: 20230322
مُعرف محوري في PubMed: PMC9986816
DOI: 10.15252/embr.202255286
PMID: 36652307
قاعدة البيانات: MEDLINE
الوصف
تدمد:1469-3178
DOI:10.15252/embr.202255286