دورية أكاديمية
أعرض في EDS

Human lung carcinomas synthesize immunoregulatory glucocorticoids.

التفاصيل البيبلوغرافية
العنوان: Human lung carcinomas synthesize immunoregulatory glucocorticoids.
المؤلفون: Merk VM; Chair of Biochemical Pharmacology, Department of Biology, University of Konstanz, Konstanz, Germany., Grob L; Chair of Biochemical Pharmacology, Department of Biology, University of Konstanz, Konstanz, Germany., Fleischmann A; Pathology, Kantonspital Münsterlingen, Münsterlingen, Switzerland., Brunner T; Chair of Biochemical Pharmacology, Department of Biology, University of Konstanz, Konstanz, Germany. Thomas.Brunner@uni-konstanz.de.
المصدر: Genes and immunity [Genes Immun] 2023 Feb; Vol. 24 (1), pp. 52-56. Date of Electronic Publication: 2023 Jan 18.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 100953417 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5470 (Electronic) Linking ISSN: 14664879 NLM ISO Abbreviation: Genes Immun Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Houndmills, Basingstoke, Hampshire, UK : Nature Pub. Group,
مواضيع طبية MeSH: Lung Neoplasms*/drug therapy , Lung Neoplasms*/genetics , Carcinoma*, Humans ; Glucocorticoids ; Lung/metabolism ; Lymphocyte Activation ; Tumor Microenvironment
مستخلص: The need for new options in lung cancer treatment inevitably leads back to basic research. The tumor itself and the tumor environment especially the interaction with the immune system need to be better understood to develop targeted therapies. In the context of lung cancer glucocorticoids (GC) are mainly known as a combination drug to attenuate side-effects of chemotherapies. However, endogenous extra-adrenal GC have been shown to substantially regulate local immune responses within various tissues, including the lung. In this study we investigated whether primary lung tumors have maintained the capacity to synthesize GC and may thereby regulate anti-tumor immune responses. We show that several non-small cell lung carcinoma (NSCLC) and small cell lung carcinoma (SCLC) cell lines express key steroidogenic enzymes and synthesize bioactive GC under steady state conditions. We also show that tumor-derived GC can inhibit splenic T cell activation, thus demonstrating their immunoregulatory potential. Moreover, steroidogenic enzymes were detected by quantitative RT-PCR and immunohistochemistry in tissue sections of different human lung tumors, further strengthening the idea that human lung carcinomas regulate their microenvironment by releasing immunoregulatory GC, which potentially contributes to immune evasion and treatment resistance.
(© 2023. The Author(s).)
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المشرفين على المادة: 0 (Glucocorticoids)
تواريخ الأحداث: Date Created: 20230118 Date Completed: 20230222 Latest Revision: 20230302
رمز التحديث: 20230303
مُعرف محوري في PubMed: PMC9935384
DOI: 10.1038/s41435-023-00194-y
PMID: 36653475
قاعدة البيانات: MEDLINE
الوصف
تدمد:1476-5470
DOI:10.1038/s41435-023-00194-y