دورية أكاديمية
Human lung carcinomas synthesize immunoregulatory glucocorticoids.
العنوان: | Human lung carcinomas synthesize immunoregulatory glucocorticoids. |
---|---|
المؤلفون: | Merk VM; Chair of Biochemical Pharmacology, Department of Biology, University of Konstanz, Konstanz, Germany., Grob L; Chair of Biochemical Pharmacology, Department of Biology, University of Konstanz, Konstanz, Germany., Fleischmann A; Pathology, Kantonspital Münsterlingen, Münsterlingen, Switzerland., Brunner T; Chair of Biochemical Pharmacology, Department of Biology, University of Konstanz, Konstanz, Germany. Thomas.Brunner@uni-konstanz.de. |
المصدر: | Genes and immunity [Genes Immun] 2023 Feb; Vol. 24 (1), pp. 52-56. Date of Electronic Publication: 2023 Jan 18. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 100953417 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5470 (Electronic) Linking ISSN: 14664879 NLM ISO Abbreviation: Genes Immun Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: Houndmills, Basingstoke, Hampshire, UK : Nature Pub. Group, |
مواضيع طبية MeSH: | Lung Neoplasms*/drug therapy , Lung Neoplasms*/genetics , Carcinoma*, Humans ; Glucocorticoids ; Lung/metabolism ; Lymphocyte Activation ; Tumor Microenvironment |
مستخلص: | The need for new options in lung cancer treatment inevitably leads back to basic research. The tumor itself and the tumor environment especially the interaction with the immune system need to be better understood to develop targeted therapies. In the context of lung cancer glucocorticoids (GC) are mainly known as a combination drug to attenuate side-effects of chemotherapies. However, endogenous extra-adrenal GC have been shown to substantially regulate local immune responses within various tissues, including the lung. In this study we investigated whether primary lung tumors have maintained the capacity to synthesize GC and may thereby regulate anti-tumor immune responses. We show that several non-small cell lung carcinoma (NSCLC) and small cell lung carcinoma (SCLC) cell lines express key steroidogenic enzymes and synthesize bioactive GC under steady state conditions. We also show that tumor-derived GC can inhibit splenic T cell activation, thus demonstrating their immunoregulatory potential. Moreover, steroidogenic enzymes were detected by quantitative RT-PCR and immunohistochemistry in tissue sections of different human lung tumors, further strengthening the idea that human lung carcinomas regulate their microenvironment by releasing immunoregulatory GC, which potentially contributes to immune evasion and treatment resistance. (© 2023. The Author(s).) |
References: | Sci Adv. 2021 Jan 29;7(5):. (PMID: 33514551) Nat Rev Immunol. 2017 Apr;17(4):233-247. (PMID: 28192415) Eur J Biochem. 2004 Nov;271(21):4178-88. (PMID: 15511223) J Endocrinol. 2016 Apr;229(1):R17-28. (PMID: 26795718) Nat Commun. 2021 Jul 16;12(1):4360. (PMID: 34272384) J Exp Med. 2004 Dec 20;200(12):1635-46. (PMID: 15596520) Front Immunol. 2019 Jun 25;10:1438. (PMID: 31316505) Allergy. 2012 Feb;67(2):227-34. (PMID: 22111694) Mol Cell Endocrinol. 2021 Jun 15;530:111238. (PMID: 33716049) Genes Immun. 2020 May;21(3):150-168. (PMID: 32203088) CA Cancer J Clin. 2021 May;71(3):209-249. (PMID: 33538338) FEBS Lett. 1999 Jul 23;455(3):364-6. (PMID: 10437805) J Exp Med. 2010 May 10;207(5):1057-66. (PMID: 20439544) Int J Mol Sci. 2021 Aug 12;22(16):. (PMID: 34445366) Cancer Res. 2003 Jun 15;63(12):3112-20. (PMID: 12810637) Oncogene. 2011 May 26;30(21):2411-9. (PMID: 21258413) Biochim Biophys Acta. 2009 May;1793(5):764-71. (PMID: 19339209) |
المشرفين على المادة: | 0 (Glucocorticoids) |
تواريخ الأحداث: | Date Created: 20230118 Date Completed: 20230222 Latest Revision: 20230302 |
رمز التحديث: | 20230303 |
مُعرف محوري في PubMed: | PMC9935384 |
DOI: | 10.1038/s41435-023-00194-y |
PMID: | 36653475 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1476-5470 |
---|---|
DOI: | 10.1038/s41435-023-00194-y |