دورية أكاديمية
أعرض في EDS

Immunoexpression of stem cell markers SOX-2, NANOG AND OCT4 in ameloblastoma.

التفاصيل البيبلوغرافية
العنوان: Immunoexpression of stem cell markers SOX-2, NANOG AND OCT4 in ameloblastoma.
المؤلفون: Martins Balbinot K; Laboratory of Pathological Anatomy and Immunohistochemistry, Federal University of Pará, Belém, Pará, Brazil., Almeida Loureiro FJ; Cell Cultivation Laboratory, Federal University of Pará, Belém, Pará, Brazil., Chemelo GP; Cell Cultivation Laboratory, Federal University of Pará, Belém, Pará, Brazil., Alves Mesquita R; Department of Oral Surgery and Pathology, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil., Cruz Ramos AMP; Health Science Institute, Federal University of Pará, Belém, Pará, Brazil., Ramos RTJ; Biological Engineer Laboratory, Park of Science and Technology, Belém, Pará, Brazil., da Costa da Silva AL; Biological Engineer Laboratory, Park of Science and Technology, Belém, Pará, Brazil., de Menezes SAF; Department of Periodontics, Pará State University, Belém, Pará, Brazil., da Silva Kataoka MS; Cell Cultivation Laboratory, Federal University of Pará, Belém, Pará, Brazil., Alves Junior SM; Laboratory of Pathological Anatomy and Immunohistochemistry, Federal University of Pará, Belém, Pará, Brazil., Viana Pinheiro JJ; Cell Cultivation Laboratory, Federal University of Pará, Belém, Pará, Brazil.
المصدر: PeerJ [PeerJ] 2023 Jan 13; Vol. 11, pp. e14349. Date of Electronic Publication: 2023 Jan 13 (Print Publication: 2023).
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: PeerJ Inc Country of Publication: United States NLM ID: 101603425 Publication Model: eCollection Cited Medium: Internet ISSN: 2167-8359 (Electronic) Linking ISSN: 21678359 NLM ISO Abbreviation: PeerJ Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Corte Madera, CA : PeerJ Inc.
مواضيع طبية MeSH: Ameloblastoma*/genetics , Ameloblastoma*/metabolism , Neoplastic Stem Cells*/metabolism, Humans ; Biomarkers, Tumor/genetics ; Biomarkers, Tumor/metabolism ; Cell Proliferation ; Immunohistochemistry ; Nanog Homeobox Protein/genetics ; Stem Cells/metabolism ; Biomarkers/metabolism ; SOXB1 Transcription Factors/genetics ; SOXB1 Transcription Factors/metabolism ; Octamer Transcription Factor-3/genetics ; Octamer Transcription Factor-3/metabolism
مستخلص: Background: Ameloblastoma (AME) is characterized by a locally invasive growth pattern. In an attempt to justify the aggressiveness of neoplasms, the investigation of the role of stem cells has gained prominence. The SOX-2, NANOG and OCT4 proteins are important stem cell biomarkers.
Methodology: To verify the expression of these proteins in tissue samples of AME, dentigerous cyst (DC) and dental follicle (DF), immunohistochemistry was performed and indirect immunofluorescence were performed on the human AME (AME-hTERT) cell line.
Results: Revealed expression of SOX-2, NANOG and OCT4 in the tissue samples and AME-hTERT lineage. Greater immunostaining of the studied proteins was observed in AME compared to DC and DF ( p < 0.001).
Conclusions: The presence of biomarkers indicates a probable role of stem cells in the genesis and progression of AME.
Competing Interests: Rommel Thiago Jucá Ramos is an Academic Editor for PeerJ.
(© 2023 Martins Balbinot et al.)
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فهرسة مساهمة: Keywords: Ameloblastoma; Immunohistochemistry; Octamer transcription factors; SOX transcription factors; Stem cells; Transcriptomic
سلسلة جزيئية: figshare 10.6084/m9.figshare.19517200.v1; 10.6084/m9.figshare.19517263.v2; 10.6084/m9.figshare.21507090.v1; 10.6084/m9.figshare.21507096.v2; 10.6084/m9.figshare.21507102.v1; 10.6084/m9.figshare.21507117.v1
المشرفين على المادة: 0 (Biomarkers, Tumor)
0 (Nanog Homeobox Protein)
0 (NANOG protein, human)
0 (Biomarkers)
0 (SOXB1 Transcription Factors)
0 (Octamer Transcription Factor-3)
تواريخ الأحداث: Date Created: 20230119 Date Completed: 20230123 Latest Revision: 20230414
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC9841912
DOI: 10.7717/peerj.14349
PMID: 36655039
قاعدة البيانات: MEDLINE
الوصف
تدمد:2167-8359
DOI:10.7717/peerj.14349