تقرير
[Possible vaccine-induced immune thrombotic thrombocytopenia in a patient with diabetes and chronic kidney disease or random association?]
| العنوان: | [Possible vaccine-induced immune thrombotic thrombocytopenia in a patient with diabetes and chronic kidney disease or random association?] |
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| المؤلفون: | Comolli S; Scuola di Specializzazione in Nefrologia, Università degli Studi di Milano-Bicocca, Milano, Italia., Del Vecchio L; U.O. di Nefrologia e Dialisi, Ospedale Sant'Anna, ASST Lariana, Como, Italia., De Micheli V; U.O.S. Emostasi e Trombosi, ASST Lecco, Lecco, Italia., Tucci B; U.O. di Nefrologia e Dialisi, Ospedale Sant'Anna, ASST Lariana, Como, Italia., D'Amico M; U.O. di Nefrologia e Dialisi, Ospedale Sant'Anna, ASST Lariana, Como, Italia., Fumagalli G; U.O. di Nefrologia e Dialisi, Ospedale Sant'Anna, ASST Lariana, Como, Italia., Gallelli B; U.O. di Nefrologia e Dialisi, Ospedale Sant'Anna, ASST Lariana, Como, Italia., Gervasi F; U.O. di Nefrologia e Dialisi, Ospedale Sant'Anna, ASST Lariana, Como, Italia., Mezzina N; U.O. di Nefrologia e Dialisi, Ospedale Sant'Anna, ASST Lariana, Como, Italia., Tettamanti M; U.O. di Nefrologia e Dialisi, Ospedale Sant'Anna, ASST Lariana, Como, Italia., Melfa G; U.O. di Nefrologia e Dialisi, Ospedale Sant'Anna, ASST Lariana, Como, Italia. |
| المصدر: | Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia [G Ital Nefrol] 2022 Dec 21; Vol. 39 (6). Date of Electronic Publication: 2022 Dec 21. |
| نوع المنشور: | Case Reports; English Abstract |
| اللغة: | Italian |
| بيانات الدورية: | Publisher: Società Italiana di Nefrologia Country of Publication: Italy NLM ID: 9426434 Publication Model: Electronic Cited Medium: Internet ISSN: 1724-5990 (Electronic) Linking ISSN: 03935590 NLM ISO Abbreviation: G Ital Nefrol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <2013- >: Rome : Società Italiana di Nefrologia. Original Publication: Milano : Wichtig editore |
| مواضيع طبية MeSH: | COVID-19* , Thrombocytopenia*/chemically induced , Vaccines* , Diabetes Mellitus* , Renal Insufficiency, Chronic* , Thrombosis*, Male ; Humans ; Middle Aged ; Aged ; ChAdOx1 nCoV-19 ; Ad26COVS1 ; COVID-19 Vaccines/adverse effects |
| مستخلص: | We report the case of a 75-year-old man who developed acute myocardial infarction 12 hours after the first dose of ChAdOx1 nCov-19 vaccine. The event was associated with a transient decrease of platelet count and the detection of anti-PF4 antibodies approximately 45 days after the event. Vaccine-induced thrombotic thrombocytopenia (VITT) is characterized by the onset of venous or arterial thrombosis in temporal relationship to the administration of anti-Sars-Cov-2 viral vector vaccines (ChAdOx1 nCov-19 and Ad26.COV2.S), thrombocytopenia and the production of anti-PF4 antibodies. It occurs mainly at a young age, even if the median age is 54 years; it is often associated with thrombosis in atypical sites, such as the cerebral sinus. Our reported case does not present all the diagnostic criteria of VITT. However, the close temporal relationship between ChAdOx1 nCov-19 vaccine administration, thrombosis, and concomitant anti-PF4 antibodies positivity makes the case suggestive of a possible slight form of VITT. (Copyright by Società Italiana di Nefrologia SIN, Rome, Italy.) |
| فهرسة مساهمة: | Keywords: ChAdOx1 nCov-19; Sars-CoV-2; VITT; chronic kidney disease; vaccine; vaccine-induced immune thrombotic thrombocytopenia |
| المشرفين على المادة: | B5S3K2V0G8 (ChAdOx1 nCoV-19) JT2NS6183B (Ad26COVS1) 0 (Vaccines) 0 (COVID-19 Vaccines) |
| تواريخ الأحداث: | Date Created: 20230119 Date Completed: 20230120 Latest Revision: 20230120 |
| رمز التحديث: | 20240513 |
| PMID: | 36655834 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1724-5990 |
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