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Differential proteomics of Zika virus (ZIKV) infection reveals molecular changes potentially involved in immune system evasion by a Brazilian strain of ZIKV.

التفاصيل البيبلوغرافية
العنوان: Differential proteomics of Zika virus (ZIKV) infection reveals molecular changes potentially involved in immune system evasion by a Brazilian strain of ZIKV.
المؤلفون: Tatara JM; Post-Graduation Program in Cellular and Molecular Biology, Federal University of Rio Grande do Sul, Av Ipiranga, 2752 suit 709, Porto Alegre, RS, Brazil., Rosa RL; Post-Graduation Program in Cellular and Molecular Biology, Federal University of Rio Grande do Sul, Av Ipiranga, 2752 suit 709, Porto Alegre, RS, Brazil., Varela APM; Department of Microbiology, Immunology and Parasitology, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.; Graduate Program in Biosciences, Federal University of Health Sciences of Porto Alegre, Porto Alegre, Brazil., Teixeira TF; Center for Experimental Cardiology, Institute of Cardiology, Porto Alegre, Brazil., Sesterheim P; Center for Experimental Cardiology, Institute of Cardiology, Porto Alegre, Brazil., Gris A; Department of Veterinary Pathology, Faculty of Veterinary Medicine, Federal University of Rio Grande do Sul, Porto Alegre, Brazil., Driemeier D; Department of Veterinary Pathology, Faculty of Veterinary Medicine, Federal University of Rio Grande do Sul, Porto Alegre, Brazil., Moraes ANS; Post-Graduation Program in Cellular and Molecular Biology, Federal University of Rio Grande do Sul, Av Ipiranga, 2752 suit 709, Porto Alegre, RS, Brazil., Berger M; Experimental Research Center, Clinical Hospital of Porto Alegre, Porto Alegre, Brazil., Peña RD; Sanford Burnham Prebys Medical Discovery Institute, La Jolla, USA., Roehe PM; Department of Microbiology, Immunology and Parasitology, Federal University of Rio Grande do Sul, Porto Alegre, Brazil., Souza DOG; Department of Biochemistry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil., Guimarães JA; Post-Graduation Program in Cellular and Molecular Biology, Federal University of Rio Grande do Sul, Av Ipiranga, 2752 suit 709, Porto Alegre, RS, Brazil.; Center for Experimental Cardiology, Institute of Cardiology, Porto Alegre, Brazil., Campos AR; Sanford Burnham Prebys Medical Discovery Institute, La Jolla, USA., Santi L; Post-Graduation Program in Cellular and Molecular Biology, Federal University of Rio Grande do Sul, Av Ipiranga, 2752 suit 709, Porto Alegre, RS, Brazil.; Experimental Research Center, Clinical Hospital of Porto Alegre, Porto Alegre, Brazil.; Faculty of Pharmacy, Federal University of Rio Grande do Sul, Porto Alegre, Brazil., Beys-da-Silva WO; Post-Graduation Program in Cellular and Molecular Biology, Federal University of Rio Grande do Sul, Av Ipiranga, 2752 suit 709, Porto Alegre, RS, Brazil. walter.beys@ufrgs.br.; Experimental Research Center, Clinical Hospital of Porto Alegre, Porto Alegre, Brazil. walter.beys@ufrgs.br.; Faculty of Pharmacy, Federal University of Rio Grande do Sul, Porto Alegre, Brazil. walter.beys@ufrgs.br.
المصدر: Archives of virology [Arch Virol] 2023 Jan 20; Vol. 168 (2), pp. 70. Date of Electronic Publication: 2023 Jan 20.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Springer-Verlag Country of Publication: Austria NLM ID: 7506870 Publication Model: Electronic Cited Medium: Internet ISSN: 1432-8798 (Electronic) Linking ISSN: 03048608 NLM ISO Abbreviation: Arch Virol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Wien, New York, Springer-Verlag.
مواضيع طبية MeSH: Zika Virus*/physiology , Zika Virus Infection*/immunology , Immune Evasion*, Animals ; Mice ; Brazil ; Chlorocebus aethiops ; Mice, Inbred C57BL ; Proteomics ; Vero Cells
مستخلص: Zika virus (ZIKV) is an arbovirus that was responsible for multiple outbreaks from 2007 to 2015. It has been linked to cases of microcephaly in Brazil in 2015, among other neurological disorders. Differences among strains might be the reason for different clinical outcomes of infection. To evaluate this hypothesis, we performed a comparative proteomic analysis of Vero cells infected with the African strain MR766 (ZIKVAFR) and the Brazilian strain 17 SM (ZIKVBR). A total of 550 proteins were identified as differentially expressed in ZIKVAFR- or ZIKVBR-infected cells compared to the control. The main findings included upregulation of immune system pathways (neutrophil degranulation and adaptive/innate immune system) and potential activation of immune-system-related pathways by ZIKVAFR (mTOR, JAK-STAT, NF-κB, and others) compared with the ZIKVBR/control. In addition, phagocytosis by macrophages and engulfment of leukocytes were activated in ZIKVAFR infection. An in vivo analysis using an immunocompetent C57BL/6N mouse model identified interstitial pneumonia with neutrophil infiltration in the lungs only in mice infected with ZIKVBR at 48 hours postinfection, with a significant amount of virus detected. Likewise, only animals infected with ZIKVBR had viral material in the cytoplasm of lung macrophages. These results suggest that activation of the immune system by ZIKVAFR infection may lead to faster viral clearance by immune cells.
(© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Austria, part of Springer Nature.)
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معلومات مُعتمدة: 14/2016 Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
تواريخ الأحداث: Date Created: 20230119 Date Completed: 20230124 Latest Revision: 20230213
رمز التحديث: 20230214
DOI: 10.1007/s00705-022-05629-x
PMID: 36658439
قاعدة البيانات: MEDLINE
الوصف
تدمد:1432-8798
DOI:10.1007/s00705-022-05629-x