دورية أكاديمية
2-(Benzhydryl sulfinyl)-N-sec-butylacetamide) isolated from fig augmented trastuzumab-triggered phagocytic killing of cancer cells through interface with Fcγ receptor.
| العنوان: | 2-(Benzhydryl sulfinyl)-N-sec-butylacetamide) isolated from fig augmented trastuzumab-triggered phagocytic killing of cancer cells through interface with Fcγ receptor. |
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| المؤلفون: | Ali ET; Department of Clinical Laboratory Sciences, College of Pharmacy, University of Basrah, Basrah, Iraq., Al-Salman HNK; Department of Pharmaceutical Chemistry, College of Pharmacy, University of Basrah, Iraq., Rasool KH; Department of Biology, College of Science, Mustansiriyah University, Baghdad, Iraq., Jabir MS; Division of Biotechnology, Department of Applied Sciences, University of Technology, Baghdad, Iraq., Ghimire TR; Department of Zoology, Tri-Chandra Multiple College Tribhuvan University, Kathmandu, Nepal., Shari FH; Department of Clinical Laboratory Sciences, College of Pharmacy, University of Basrah, Basrah, Iraq., Hussein HH; Department of Pharmaceutical Chemistry, College of Pharmacy, University of Basrah, Iraq., Al-Fregi AA; Department of Chemistry, College of Science, University of Basrah, Iraq., Sulaiman GM; Division of Biotechnology, Department of Applied Sciences, University of Technology, Baghdad, Iraq., Khalil KAA; Department of Medical Laboratories, College of Applied Medical Sciences, University of Bisha, Bisha, Saudi Arabia.; Department of Medical Laboratory Sciences, Faculty of Medicine and Health Sciences, University of Hodeidah, Yemen., Ahmed EM; Department of Medical Laboratories, College of Applied Medical Sciences, University of Bisha, Bisha, Saudi Arabia.; Department of Clinical Chemistry, Faculty of Medical Laboratory Sciences, University of El Imam El Mahdi, Kosti, Sudan., Soliman MTA; Department of Medical Laboratories, College of Applied Medical Sciences, University of Bisha, Bisha, Saudi Arabia. |
| المصدر: | Natural product research [Nat Prod Res] 2023 Nov-Dec; Vol. 37 (24), pp. 4112-4120. Date of Electronic Publication: 2023 Jan 20. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Taylor & Francis Health Sciences Country of Publication: England NLM ID: 101167924 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1478-6427 (Electronic) Linking ISSN: 14786419 NLM ISO Abbreviation: Nat Prod Res Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Milton Park, UK : Taylor & Francis Health Sciences, c2003- |
| مواضيع طبية MeSH: | Ficus* , Neoplasms*, Trastuzumab/pharmacology ; Receptors, IgG ; Spectroscopy, Fourier Transform Infrared ; Plant Extracts/chemistry ; Phagocytes ; Solvents |
| مستخلص: | The objective of the current study was to extract 2-(benzhydryl sulfinyl)-N-sec-butylacetamide), a novel compound from fig, and then determine its role in enhancing trastuzumab-triggered phagocytic killing of SKOV-3 cancer cells. In this study, Soxhlet was used to extract the compound from the mature and air-dried fig fruits. The production of the isolated extracts was enhanced by using polar and non-polar solvents. Several solvents, such as methanol, ethyl acetate, chloroform, and n-hexane, were used to isolate the effective compound 2-(benzhydryl sulfinyl)-N-sec-butylacetamide) from the organic layer. UV-spectroscopy, FT-IR, 1 H-NMR, and 13 C-NMR were applied to identify the purified compound. The in vitro and in vivo assays demonstrated that the 2-(benzhydryl sulfinyl)-N-sec-butylacetamide) can increase the activity of the phagocytic cells, via the interaction with FcY receptors, along with trastuzumab, and the pathway can use a model for the therapeutic strategy for effective treatment of ovarian cancer cells. |
| فهرسة مساهمة: | Keywords: 2-(benzhydryl sulfinyl)-N-sec-butylacetamide); Fcγ R; cancer cells; phagocytosis; trastuzumab |
| المشرفين على المادة: | P188ANX8CK (Trastuzumab) 0 (Receptors, IgG) 0 (Plant Extracts) 0 (Solvents) |
| تواريخ الأحداث: | Date Created: 20230120 Date Completed: 20231204 Latest Revision: 20231204 |
| رمز التحديث: | 20231204 |
| DOI: | 10.1080/14786419.2023.2169861 |
| PMID: | 36661202 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1478-6427 |
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| DOI: | 10.1080/14786419.2023.2169861 |