دورية أكاديمية
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Peptides from the Sea Anemone Metridium senile with Modified Inhibitor Cystine Knot (ICK) Fold Inhibit Nicotinic Acetylcholine Receptors.

التفاصيل البيبلوغرافية
العنوان: Peptides from the Sea Anemone Metridium senile with Modified Inhibitor Cystine Knot (ICK) Fold Inhibit Nicotinic Acetylcholine Receptors.
المؤلفون: Kasheverov IE; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, str. Miklukho-Maklaya 16/10, 117997 Moscow, Russia., Logashina YA; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, str. Miklukho-Maklaya 16/10, 117997 Moscow, Russia.; Institute of Molecular Medicine, Sechenov First Moscow State Medical University, Trubetskaya str. 8, bld. 2, 119991 Moscow, Russia., Kornilov FD; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, str. Miklukho-Maklaya 16/10, 117997 Moscow, Russia.; Moscow Institute of Physics and Technology, Institutsky per., 9, 141700 Dolgoprudnyi, Russia., Lushpa VA; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, str. Miklukho-Maklaya 16/10, 117997 Moscow, Russia.; Moscow Institute of Physics and Technology, Institutsky per., 9, 141700 Dolgoprudnyi, Russia., Maleeva EE; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, str. Miklukho-Maklaya 16/10, 117997 Moscow, Russia., Korolkova YV; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, str. Miklukho-Maklaya 16/10, 117997 Moscow, Russia., Yu J; Medical School, Guangxi University, Nanning 530004, China., Zhu X; Medical School, Guangxi University, Nanning 530004, China., Zhangsun D; Medical School, Guangxi University, Nanning 530004, China., Luo S; Medical School, Guangxi University, Nanning 530004, China., Stensvåg K; Faculty of Biosciences, Fisheries and Economics, Norwegian College of Fishery Science, UiT-The Arctic University of Norway, NO 9037 Tromsø, Norway., Kudryavtsev DS; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, str. Miklukho-Maklaya 16/10, 117997 Moscow, Russia., Mineev KS; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, str. Miklukho-Maklaya 16/10, 117997 Moscow, Russia.; Moscow Institute of Physics and Technology, Institutsky per., 9, 141700 Dolgoprudnyi, Russia., Andreev YA; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, str. Miklukho-Maklaya 16/10, 117997 Moscow, Russia.; Institute of Molecular Medicine, Sechenov First Moscow State Medical University, Trubetskaya str. 8, bld. 2, 119991 Moscow, Russia.
المصدر: Toxins [Toxins (Basel)] 2022 Dec 30; Vol. 15 (1). Date of Electronic Publication: 2022 Dec 30.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101530765 Publication Model: Electronic Cited Medium: Internet ISSN: 2072-6651 (Electronic) Linking ISSN: 20726651 NLM ISO Abbreviation: Toxins (Basel) Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel : MDPI
مواضيع طبية MeSH: Nicotinic Antagonists*/chemistry , Nicotinic Antagonists*/isolation & purification , Nicotinic Antagonists*/pharmacology , Peptides*/chemistry , Peptides*/isolation & purification , Peptides*/pharmacology , Receptors, Nicotinic*/metabolism , Sea Anemones*/chemistry, Animals ; Rats ; Cystine
مستخلص: Nicotinic acetylcholine receptors (nAChRs) play an important role in the functioning of the central and peripheral nervous systems, and other organs of living creatures. There are several subtypes of nAChRs, and almost all of them are considered as pharmacological targets in different pathological states. The crude venom of the sea anemone Metridium senile showed the ability to interact with nAChRs. Four novel peptides (Ms11a-1-Ms11a-4) with nAChR binding activity were isolated. These peptides stabilized by three disulfide bridges have no noticeable homology with any known peptides. Ms11a-1-Ms11a-4 showed different binding activity towards the muscle-type nAChR from the Torpedo californica ray. The study of functional activity and selectivity for the most potent peptide (Ms11a-3) revealed the highest antagonism towards the heterologous rat α9α10 nAChR compared to the muscle and α7 receptors. Structural NMR analysis of two toxins (Ms11a-2 and Ms11a-3) showed that they belong to a new variant of the inhibitor cystine knot (ICK) fold but have a prolonged loop between the fifth and sixth cysteine residues. Peptides Ms11a-1-Ms11a-4 could represent new pharmacological tools since they have structures different from other known nAChRs inhibitors.
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فهرسة مساهمة: Keywords: ICK fold peptides; Metridium senile; NMR structure; electrophysiology; nicotinic acetylcholine receptors; radioligand assay; sea anemone venom
المشرفين على المادة: 48TCX9A1VT (Cystine)
0 (Nicotinic Antagonists)
0 (Peptides)
0 (Receptors, Nicotinic)
تواريخ الأحداث: Date Created: 20230120 Date Completed: 20230227 Latest Revision: 20231118
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC9866706
DOI: 10.3390/toxins15010028
PMID: 36668848
قاعدة البيانات: MEDLINE
الوصف
تدمد:2072-6651
DOI:10.3390/toxins15010028