دورية أكاديمية
أعرض في EDS

Activation of Early Proinflammatory Responses by TBEV NS1 Varies between the Strains of Various Subtypes.

التفاصيل البيبلوغرافية
العنوان: Activation of Early Proinflammatory Responses by TBEV NS1 Varies between the Strains of Various Subtypes.
المؤلفون: Starodubova E; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia., Tuchynskaya K; FSASI 'Chumakov FSC R&D IBP RAS' (Institute of Poliomyelitis), prem. 8, k.17, pos. Institut Poliomyelita, poselenie Moskovskiy, 108811 Moscow, Russia., Kuzmenko Y; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia., Latanova A; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia., Tutyaeva V; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia., Karpov V; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia., Karganova G; FSASI 'Chumakov FSC R&D IBP RAS' (Institute of Poliomyelitis), prem. 8, k.17, pos. Institut Poliomyelita, poselenie Moskovskiy, 108811 Moscow, Russia.
المصدر: International journal of molecular sciences [Int J Mol Sci] 2023 Jan 05; Vol. 24 (2). Date of Electronic Publication: 2023 Jan 05.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI, [2000-
مواضيع طبية MeSH: Encephalitis Viruses, Tick-Borne*/classification , Encephalitis Viruses, Tick-Borne*/physiology , Encephalitis, Tick-Borne*/immunology , Encephalitis, Tick-Borne*/virology , Viral Nonstructural Proteins*/metabolism, Animals ; Mice ; Interleukin-10/genetics ; Zoonoses
مستخلص: Tick-borne encephalitis (TBE) is an emerging zoonosis that may cause long-term neurological sequelae or even death. Thus, there is a growing interest in understanding the factors of TBE pathogenesis. Viral genetic determinants may greatly affect the severity and consequences of TBE. In this study, nonstructural protein 1 (NS1) of the tick-borne encephalitis virus (TBEV) was tested as such a determinant. NS1s of three strains with similar neuroinvasiveness belonging to the European, Siberian and Far-Eastern subtypes of TBEV were studied. Transfection of mouse cells with plasmids encoding NS1 of the three TBEV subtypes led to different levels of NS1 protein accumulation in and secretion from the cells. NS1s of TBEV were able to trigger cytokine production either in isolated mouse splenocytes or in mice after delivery of NS1 encoding plasmids. The profile and dynamics of TNF-α, IL-6, IL-10 and IFN-γ differed between the strains. These results demonstrated the involvement of TBEV NS1 in triggering an immune response and indicated the diversity of NS1 as one of the genetic factors of TBEV pathogenicity.
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معلومات مُعتمدة: 20-04-00766 Russian Foundation for Basic Research
فهرسة مساهمة: Keywords: nonstructural protein 1 (NS1); pro-inflammatory cytokines; tick-borne encephalitis virus (TBEV)
المشرفين على المادة: 130068-27-8 (Interleukin-10)
0 (Viral Nonstructural Proteins)
تواريخ الأحداث: Date Created: 20230121 Date Completed: 20230127 Latest Revision: 20230201
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC9863113
DOI: 10.3390/ijms24021011
PMID: 36674524
قاعدة البيانات: MEDLINE
الوصف
تدمد:1422-0067
DOI:10.3390/ijms24021011