دورية أكاديمية
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Zinc- and Copper-Doped Mesoporous Borate Bioactive Glasses: Promising Additives for Potential Use in Skin Wound Healing Applications.

التفاصيل البيبلوغرافية
العنوان: Zinc- and Copper-Doped Mesoporous Borate Bioactive Glasses: Promising Additives for Potential Use in Skin Wound Healing Applications.
المؤلفون: Kermani F; Tissue Engineering Research Group (TERG), Department of Anatomy and Cell Biology, School of Medicine, Mashhad University of Medical Sciences, Mashhad 917794-8564, Iran., Nazarnezhad S; Tissue Engineering Research Group (TERG), Department of Anatomy and Cell Biology, School of Medicine, Mashhad University of Medical Sciences, Mashhad 917794-8564, Iran., Mollaei Z; Department of Materials Engineering, Faculty of Engineering, Ferdowsi University of Mashhad (FUM), Azadi Sq., Mashhad 917794-8564, Iran., Mollazadeh S; Department of Materials Engineering, Faculty of Engineering, Ferdowsi University of Mashhad (FUM), Azadi Sq., Mashhad 917794-8564, Iran., Ebrahimzadeh-Bideskan A; Department of Anatomy and Cell Biology, School of Medicine, Mashhad University of Medical Sciences, Mashhad 917794-8564, Iran.; Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad 917794-8564, Iran., Askari VR; Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad 917794-8564, Iran.; International UNESCO Center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad 917794-8564, Iran., Oskuee RK; Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad 917794-8564, Iran.; Department of Medical Biotechnology and Nanotechnology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad 917794-8564, Iran., Moradi A; Orthopedic Research Center, Mashhad University of Medical Sciences, Mashhad 917794-8564, Iran., Hosseini SA; Department of Medical Biotechnology and Nanotechnology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad 917794-8564, Iran., Azari Z; Department of Anatomy and Cell Biology, School of Medicine, Mashhad University of Medical Sciences, Mashhad 917794-8564, Iran., Baino F; Institute of Materials Physics and Engineering, Applied Science and Technology Department, Politecnico di Torino, Corso Duca degli Abruzzi 24, 10129 Torino, Italy., Kargozar S; Tissue Engineering Research Group (TERG), Department of Anatomy and Cell Biology, School of Medicine, Mashhad University of Medical Sciences, Mashhad 917794-8564, Iran.
المصدر: International journal of molecular sciences [Int J Mol Sci] 2023 Jan 09; Vol. 24 (2). Date of Electronic Publication: 2023 Jan 09.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI, [2000-
مواضيع طبية MeSH: Copper*/pharmacology , Zinc*/pharmacology, Animals ; Mice ; Borates/pharmacology ; Glass ; Anti-Bacterial Agents/pharmacology ; Durapatite/pharmacology ; Wound Healing
مستخلص: In this study, zinc (Zn)- and copper (Cu)-doped 13-93B3 borate mesoporous bioactive glasses (MBGs) were successfully synthesized using nitrate precursors in the presence of Pluronic P123. We benefited from computational approaches for predicting and confirming the experimental findings. The changes in the dynamic surface tension (SFT) of simulated body fluid (SBF) were investigated using the Du Noüy ring method to shed light on the mineralization process of hydroxyapatite (HAp) on the glass surface. The obtained MBGs were in a glassy state before incubation in SBF. The formation of an apatite-like layer on the SBF-incubated borate glasses was investigated by X-ray diffraction (XRD) and scanning electron microscopy (SEM). The incorporation of Zn and Cu into the basic composition of 13-93B3 glass led to changes in the glass transition temperature (Tg) (773 to 556 °C), particle size (373 to 64 nm), zeta potential (−12 to −26 mV), and specific surface area (SBET) (54 to 123 m2/g). Based on the K-means algorithm and chi-square automatic interaction detection (CHAID) tree, we found that the SFT of SBF is an important factor for the prediction and confirmation of the HAp mineralization process on the glasses. Furthermore, we proposed a simple calculation, based on SFT variation, to quantify the bioactivity of MBGs. The doped and dopant-free borate MBGs could enhance the proliferation of mouse fibroblast L929 cells at a concentration of 0.5 mg/mL. These glasses also induced very low hemolysis (<5%), confirming good compatibility with red blood cells. The results of the antibacterial test revealed that all the samples could significantly decrease the viability of Pseudomonas aeruginosa. In summary, we showed that Cu-/Zn-doped borate MBGs can be fabricated using a cost-effective method and also show promise for wound healing/skin tissue engineering applications, as especially supported by the cell test with fibroblasts, good compatibility with blood, and antibacterial properties.
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فهرسة مساهمة: Keywords: 13-93B3 borate bioactive glass; antibacterial properties; bioactivity; data science; mesoporous bioactive glasses (MBGs); tissue engineering; wound healing
المشرفين على المادة: 789U1901C5 (Copper)
J41CSQ7QDS (Zinc)
0 (Borates)
0 (Anti-Bacterial Agents)
91D9GV0Z28 (Durapatite)
تواريخ الأحداث: Date Created: 20230121 Date Completed: 20230124 Latest Revision: 20230308
رمز التحديث: 20230308
مُعرف محوري في PubMed: PMC9861609
DOI: 10.3390/ijms24021304
PMID: 36674818
قاعدة البيانات: MEDLINE
الوصف
تدمد:1422-0067
DOI:10.3390/ijms24021304