دورية أكاديمية
أعرض في EDS

Role of Transient Receptor Potential Vanilloid 1 in Sonic Hedgehog-Dependent Taste Bud Differentiation.

التفاصيل البيبلوغرافية
العنوان: Role of Transient Receptor Potential Vanilloid 1 in Sonic Hedgehog-Dependent Taste Bud Differentiation.
المؤلفون: Rhee YH; Beckman Laser Institute Korea, Dankook University, 119 Dandae-ro, Cheonan 31116, Republic of Korea.; Medical Laser Research Center, Dankook University, 119 Dandae-ro, Cheonan 31116, Republic of Korea.; Laser Translational Clinical Trial Center, Dankook University Hospital, Cheonan 31116, Republic of Korea., Choi YH; Laser Translational Clinical Trial Center, Dankook University Hospital, Cheonan 31116, Republic of Korea., Hu AC; Beckman Laser Institute and Medical Clinic, University of California Irvine, 1002 Health Sciences Rd., Irvine, CA 92697, USA., Lee MY; Beckman Laser Institute Korea, Dankook University, 119 Dandae-ro, Cheonan 31116, Republic of Korea.; Medical Laser Research Center, Dankook University, 119 Dandae-ro, Cheonan 31116, Republic of Korea.; Department of Otolaryngology-Head and Neck Surgery, College of Medicine, Dankook University, Cheonan 31116, Republic of Korea., Ahn JC; Beckman Laser Institute Korea, Dankook University, 119 Dandae-ro, Cheonan 31116, Republic of Korea.; Medical Laser Research Center, Dankook University, 119 Dandae-ro, Cheonan 31116, Republic of Korea., Kim S; Beckman Laser Institute Korea, Dankook University, 119 Dandae-ro, Cheonan 31116, Republic of Korea., Mo JH; Beckman Laser Institute Korea, Dankook University, 119 Dandae-ro, Cheonan 31116, Republic of Korea.; Medical Laser Research Center, Dankook University, 119 Dandae-ro, Cheonan 31116, Republic of Korea.; Laser Translational Clinical Trial Center, Dankook University Hospital, Cheonan 31116, Republic of Korea.; Department of Otolaryngology-Head and Neck Surgery, College of Medicine, Dankook University, Cheonan 31116, Republic of Korea., Woo SH; Beckman Laser Institute Korea, Dankook University, 119 Dandae-ro, Cheonan 31116, Republic of Korea.; Medical Laser Research Center, Dankook University, 119 Dandae-ro, Cheonan 31116, Republic of Korea.; Laser Translational Clinical Trial Center, Dankook University Hospital, Cheonan 31116, Republic of Korea.; Department of Otolaryngology-Head and Neck Surgery, College of Medicine, Dankook University, Cheonan 31116, Republic of Korea., Chung PS; Beckman Laser Institute Korea, Dankook University, 119 Dandae-ro, Cheonan 31116, Republic of Korea.; Medical Laser Research Center, Dankook University, 119 Dandae-ro, Cheonan 31116, Republic of Korea.; Laser Translational Clinical Trial Center, Dankook University Hospital, Cheonan 31116, Republic of Korea.; Department of Otolaryngology-Head and Neck Surgery, College of Medicine, Dankook University, Cheonan 31116, Republic of Korea.
المصدر: Life (Basel, Switzerland) [Life (Basel)] 2022 Dec 27; Vol. 13 (1). Date of Electronic Publication: 2022 Dec 27.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101580444 Publication Model: Electronic Cited Medium: Print ISSN: 2075-1729 (Print) Linking ISSN: 20751729 NLM ISO Abbreviation: Life (Basel) Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI AG, 2011-
مستخلص: Taste bud cell differentiation is extremely important for taste sensation. Immature taste bud cells cannot function during taste perception transmission to the nerve. In this study, we investigated whether hedgehog signaling affected taste bud cell differentiation and whether transient receptor potential vanilloid 1 (TRPV1) played a key role in dry mouth. The induction of dry mouth due to salivary gland resection (SGR) was confirmed on the basis of reduced salivation and disrupted fungiform papillae. The expression of keratin 8 (K8) of taste bud cells, neurofilament (NF), sonic hedgehog (Shh), and glioma-associated oncogene homolog 1 (Gli1) around taste bud cells was downregulated; however, the expression of TRPV1, P2X purinoceptor 3 (P2X3), and hematopoietic stem cell factor (c-Kit) was upregulated at the NF ends in the dry mouth group. To investigate the effect of TRPV1 defect on dry mouth, we induced dry mouth in the TRPV-/- group. The K8, NF, and P2X3 expression patterns were the same in the TRPV1 wild-type and TRPV1-/- dry mouth groups. However, Shh and c-Kit expression decreased regardless of dry mouth in the case of TRPV1 deficiency. These results indicated that TRPV1 positively regulated proliferation during taste bud cell injury by blocking the Shh/Gli1 pathway. In addition, not only cell proliferation but also differentiation of taste bud cells could not be regulated under TRPV1-deficiency conditions. Thus, TRPV1 positively regulates taste bud cell innervation and differentiation; this finding could be valuable in the clinical treatment of dry mouth-related taste dysfunction.
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معلومات مُعتمدة: 2020R1I1A1A01052306 National Research Foundation of Korea; MSIT; NRF-2018K1A4A3A02060572 National Research Foundation of Korea; HI20C2088 Republic of Korea Korea Health Industry Development Institute
فهرسة مساهمة: Keywords: innervation; sonic hedgehog; taste bud cells; transient receptor potential vanilloid 1
تواريخ الأحداث: Date Created: 20230121 Latest Revision: 20230201
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC9862146
DOI: 10.3390/life13010075
PMID: 36676024
قاعدة البيانات: MEDLINE
الوصف
تدمد:2075-1729
DOI:10.3390/life13010075