دورية أكاديمية
Role of Transient Receptor Potential Vanilloid 1 in Sonic Hedgehog-Dependent Taste Bud Differentiation.
العنوان: | Role of Transient Receptor Potential Vanilloid 1 in Sonic Hedgehog-Dependent Taste Bud Differentiation. |
---|---|
المؤلفون: | Rhee YH; Beckman Laser Institute Korea, Dankook University, 119 Dandae-ro, Cheonan 31116, Republic of Korea.; Medical Laser Research Center, Dankook University, 119 Dandae-ro, Cheonan 31116, Republic of Korea.; Laser Translational Clinical Trial Center, Dankook University Hospital, Cheonan 31116, Republic of Korea., Choi YH; Laser Translational Clinical Trial Center, Dankook University Hospital, Cheonan 31116, Republic of Korea., Hu AC; Beckman Laser Institute and Medical Clinic, University of California Irvine, 1002 Health Sciences Rd., Irvine, CA 92697, USA., Lee MY; Beckman Laser Institute Korea, Dankook University, 119 Dandae-ro, Cheonan 31116, Republic of Korea.; Medical Laser Research Center, Dankook University, 119 Dandae-ro, Cheonan 31116, Republic of Korea.; Department of Otolaryngology-Head and Neck Surgery, College of Medicine, Dankook University, Cheonan 31116, Republic of Korea., Ahn JC; Beckman Laser Institute Korea, Dankook University, 119 Dandae-ro, Cheonan 31116, Republic of Korea.; Medical Laser Research Center, Dankook University, 119 Dandae-ro, Cheonan 31116, Republic of Korea., Kim S; Beckman Laser Institute Korea, Dankook University, 119 Dandae-ro, Cheonan 31116, Republic of Korea., Mo JH; Beckman Laser Institute Korea, Dankook University, 119 Dandae-ro, Cheonan 31116, Republic of Korea.; Medical Laser Research Center, Dankook University, 119 Dandae-ro, Cheonan 31116, Republic of Korea.; Laser Translational Clinical Trial Center, Dankook University Hospital, Cheonan 31116, Republic of Korea.; Department of Otolaryngology-Head and Neck Surgery, College of Medicine, Dankook University, Cheonan 31116, Republic of Korea., Woo SH; Beckman Laser Institute Korea, Dankook University, 119 Dandae-ro, Cheonan 31116, Republic of Korea.; Medical Laser Research Center, Dankook University, 119 Dandae-ro, Cheonan 31116, Republic of Korea.; Laser Translational Clinical Trial Center, Dankook University Hospital, Cheonan 31116, Republic of Korea.; Department of Otolaryngology-Head and Neck Surgery, College of Medicine, Dankook University, Cheonan 31116, Republic of Korea., Chung PS; Beckman Laser Institute Korea, Dankook University, 119 Dandae-ro, Cheonan 31116, Republic of Korea.; Medical Laser Research Center, Dankook University, 119 Dandae-ro, Cheonan 31116, Republic of Korea.; Laser Translational Clinical Trial Center, Dankook University Hospital, Cheonan 31116, Republic of Korea.; Department of Otolaryngology-Head and Neck Surgery, College of Medicine, Dankook University, Cheonan 31116, Republic of Korea. |
المصدر: | Life (Basel, Switzerland) [Life (Basel)] 2022 Dec 27; Vol. 13 (1). Date of Electronic Publication: 2022 Dec 27. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101580444 Publication Model: Electronic Cited Medium: Print ISSN: 2075-1729 (Print) Linking ISSN: 20751729 NLM ISO Abbreviation: Life (Basel) Subsets: PubMed not MEDLINE |
أسماء مطبوعة: | Original Publication: Basel, Switzerland : MDPI AG, 2011- |
مستخلص: | Taste bud cell differentiation is extremely important for taste sensation. Immature taste bud cells cannot function during taste perception transmission to the nerve. In this study, we investigated whether hedgehog signaling affected taste bud cell differentiation and whether transient receptor potential vanilloid 1 (TRPV1) played a key role in dry mouth. The induction of dry mouth due to salivary gland resection (SGR) was confirmed on the basis of reduced salivation and disrupted fungiform papillae. The expression of keratin 8 (K8) of taste bud cells, neurofilament (NF), sonic hedgehog (Shh), and glioma-associated oncogene homolog 1 (Gli1) around taste bud cells was downregulated; however, the expression of TRPV1, P2X purinoceptor 3 (P2X3), and hematopoietic stem cell factor (c-Kit) was upregulated at the NF ends in the dry mouth group. To investigate the effect of TRPV1 defect on dry mouth, we induced dry mouth in the TRPV-/- group. The K8, NF, and P2X3 expression patterns were the same in the TRPV1 wild-type and TRPV1-/- dry mouth groups. However, Shh and c-Kit expression decreased regardless of dry mouth in the case of TRPV1 deficiency. These results indicated that TRPV1 positively regulated proliferation during taste bud cell injury by blocking the Shh/Gli1 pathway. In addition, not only cell proliferation but also differentiation of taste bud cells could not be regulated under TRPV1-deficiency conditions. Thus, TRPV1 positively regulates taste bud cell innervation and differentiation; this finding could be valuable in the clinical treatment of dry mouth-related taste dysfunction. |
References: | Curr Top Dev Biol. 2015;115:321-33. (PMID: 26589931) Dev Biol. 2003 Mar 15;255(2):263-77. (PMID: 12648489) Cochrane Database Syst Rev. 2015 Oct 05;(10):CD003782. (PMID: 26436597) Development. 2015 Nov 1;142(21):3620-9. (PMID: 26534983) PLoS Genet. 2014 Oct 09;10(10):e1004709. (PMID: 25299669) J Oral Pathol Med. 2017 Oct;46(9):829-833. (PMID: 28009451) Development. 2015 Dec 15;142(24):4309-17. (PMID: 26525674) Biochem Biophys Res Commun. 2019 Jul 12;515(1):149-155. (PMID: 31133375) Int J Mol Sci. 2018 Dec 18;19(12):. (PMID: 30567389) Assay Drug Dev Technol. 2010 Dec;8(6):703-13. (PMID: 21158685) PLoS One. 2013 Jun 18;8(6):e66314. (PMID: 23824276) PLoS Genet. 2018 Feb 7;14(2):e1007058. (PMID: 29415007) Cells. 2018 Jul 11;7(7):. (PMID: 29997338) Lab Anim. 1999 Apr;33(2):192-3. (PMID: 10780824) Proc Natl Acad Sci U S A. 2018 Jan 9;115(2):E200-E209. (PMID: 29279401) Front Cell Neurosci. 2021 Feb 05;14:612480. (PMID: 33613196) Sci Rep. 2015 Mar 02;5:8661. (PMID: 25726964) J Cell Mol Med. 2016 Jun;20(6):1118-27. (PMID: 26865051) Development. 2017 Sep 1;144(17):3054-3065. (PMID: 28743797) Stem Cells. 2014 Dec;32(12):3183-95. (PMID: 25092424) J Gerontol A Biol Sci Med Sci. 2012 Apr;67(4):336-44. (PMID: 22056740) PLoS Genet. 2016 Nov 28;12(11):e1006442. (PMID: 27893742) Neurochem Int. 2009 Dec;55(8):768-74. (PMID: 19651168) Cell Tissue Res. 2010 Mar;339(3):513-25. (PMID: 20143239) Chem Senses. 2005 Jan;30 Suppl 1:i50-1. (PMID: 15738190) Int J Mol Sci. 2019 Mar 16;20(6):. (PMID: 30884865) Mol Ther Nucleic Acids. 2020 Oct 14;22:924-936. (PMID: 33251043) J Invest Dermatol. 2012 Apr;132(4):1253-62. (PMID: 22189789) Arch Oral Biol. 2017 Oct;82:263-270. (PMID: 28672219) Dev Biol. 2012 Jan 1;361(1):39-56. (PMID: 22024319) Annu Rev Physiol. 2017 Feb 10;79:335-356. (PMID: 28192057) Dev Dyn. 2017 Feb;246(2):135-147. (PMID: 27884045) Cell Mol Neurobiol. 2013 Jul;33(5):707-14. (PMID: 23584686) Genesis. 2011 Apr;49(4):295-306. (PMID: 21328519) Arch Histol Cytol. 2006 Dec;69(4):209-25. (PMID: 17287576) Development. 2011 Jul;138(13):2681-91. (PMID: 21652647) J Cell Physiol. 2016 Oct;231(10):2275-85. (PMID: 26892397) Biomed Res Int. 2014;2014:805236. (PMID: 24868547) J Neurophysiol. 2015 Feb 1;113(3):1034-40. (PMID: 25392175) Dev Dyn. 2014 Oct;243(10):1286-97. (PMID: 24590958) J Neurophysiol. 2016 Jun 1;115(6):2964-75. (PMID: 27009163) Mech Dev. 2001 Aug;106(1-2):143-5. (PMID: 11472844) Stem Cell Rev Rep. 2021 Jun;17(3):999-1013. (PMID: 33389681) Dev Biol. 2013 Oct 1;382(1):82-97. (PMID: 23916850) Development. 2017 Jun 15;144(12):2212-2221. (PMID: 28506989) Neuron. 2012 Mar 8;73(5):862-85. (PMID: 22405199) Bioelectromagnetics. 2016 Oct;37(7):444-54. (PMID: 27483046) Oncotarget. 2017 Oct 11;8(53):90766-90780. (PMID: 29207602) Clin Cancer Res. 2014 Jan 1;20(1):140-150. (PMID: 24150232) Cell Tissue Res. 2006 Aug;325(2):253-61. (PMID: 16552524) Neural Regen Res. 2016 Aug;11(8):1204-7. (PMID: 27651755) J Texture Stud. 2017 Aug;48(4):313-317. (PMID: 28766746) |
معلومات مُعتمدة: | 2020R1I1A1A01052306 National Research Foundation of Korea; MSIT; NRF-2018K1A4A3A02060572 National Research Foundation of Korea; HI20C2088 Republic of Korea Korea Health Industry Development Institute |
فهرسة مساهمة: | Keywords: innervation; sonic hedgehog; taste bud cells; transient receptor potential vanilloid 1 |
تواريخ الأحداث: | Date Created: 20230121 Latest Revision: 20230201 |
رمز التحديث: | 20240628 |
مُعرف محوري في PubMed: | PMC9862146 |
DOI: | 10.3390/life13010075 |
PMID: | 36676024 |
قاعدة البيانات: | MEDLINE |
تدمد: | 2075-1729 |
---|---|
DOI: | 10.3390/life13010075 |