دورية أكاديمية
Serum Metabolites Characterization Produced by Cats CKD Affected, at the 1 and 2 Stages, before and after Renal Diet.
العنوان: | Serum Metabolites Characterization Produced by Cats CKD Affected, at the 1 and 2 Stages, before and after Renal Diet. |
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المؤلفون: | Ruberti B; Pet Nutrology Research Center, Animal Nutrition and Production Department, School of Veterinary Medicine and Animal Science, University of São Paulo, 225, Duque de Caxias Norte Ave, Pirassununga, São Paulo 13635-900, Brazil., Machado DP; Pet Nutrology Research Center, Animal Nutrition and Production Department, School of Veterinary Medicine and Animal Science, University of São Paulo, 225, Duque de Caxias Norte Ave, Pirassununga, São Paulo 13635-900, Brazil.; Nutritional Development Center, Grandfood Industria e Comercio LTDA (PremieRpet®), Luiz Augusto de Oliveira Hwy, km 204, Dourado, São Paulo 13590-000, Brazil., Vendramini THA; Pet Nutrology Research Center, Animal Nutrition and Production Department, School of Veterinary Medicine and Animal Science, University of São Paulo, 225, Duque de Caxias Norte Ave, Pirassununga, São Paulo 13635-900, Brazil., Pedrinelli V; Pet Nutrology Research Center, Animal Nutrition and Production Department, School of Veterinary Medicine and Animal Science, University of São Paulo, 225, Duque de Caxias Norte Ave, Pirassununga, São Paulo 13635-900, Brazil., Marchi PH; Pet Nutrology Research Center, Animal Nutrition and Production Department, School of Veterinary Medicine and Animal Science, University of São Paulo, 225, Duque de Caxias Norte Ave, Pirassununga, São Paulo 13635-900, Brazil., Jeremias JT; Nutritional Development Center, Grandfood Industria e Comercio LTDA (PremieRpet®), Luiz Augusto de Oliveira Hwy, km 204, Dourado, São Paulo 13590-000, Brazil., Pontieri CFF; Nutritional Development Center, Grandfood Industria e Comercio LTDA (PremieRpet®), Luiz Augusto de Oliveira Hwy, km 204, Dourado, São Paulo 13590-000, Brazil., Kogika MM; Pet Nutrology Research Center, Animal Nutrition and Production Department, School of Veterinary Medicine and Animal Science, University of São Paulo, 225, Duque de Caxias Norte Ave, Pirassununga, São Paulo 13635-900, Brazil., Brunetto MA; Pet Nutrology Research Center, Animal Nutrition and Production Department, School of Veterinary Medicine and Animal Science, University of São Paulo, 225, Duque de Caxias Norte Ave, Pirassununga, São Paulo 13635-900, Brazil. |
المصدر: | Metabolites [Metabolites] 2022 Dec 27; Vol. 13 (1). Date of Electronic Publication: 2022 Dec 27. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: MDPI Country of Publication: Switzerland NLM ID: 101578790 Publication Model: Electronic Cited Medium: Print ISSN: 2218-1989 (Print) Linking ISSN: 22181989 NLM ISO Abbreviation: Metabolites Subsets: PubMed not MEDLINE |
أسماء مطبوعة: | Original Publication: Basel : MDPI |
مستخلص: | Utilizing metabolomics, a tool for measuring and characterizing low-molecular-weight substances (LMWs), to identify eventual changes in response to dietary intervention is novel in cats with chronic kidney disease (CKD), a condition characterized by retention of uremic solutes. This study aims to assess the serum metabolomic profile of cats in early stages of CKD and to compare the serum metabolomic of CKD cats after 60 days of a renal diet to evaluate the effect of dietary intervention on these metabolites. Twenty-five domestic cats were included in the study. Fifteen cats with CKD stages 1 ( n = 6) and 2 ( n = 9) according to the International Renal Interest Society (IRIS) were included in the renal groups, and a control group consisting of 10 cats was included. All animals were enrolled on a maintenance diet for 30 days before the experimental period. The metabolomics analysis was performed by gas chromatography-mass spectrometry (GC-MS). Partial least squares discriminant analysis (PLS-DA) was performed on Metaboanalyst 4.0 software. Forty-three metabolites were identified. Citric acid and monostearin were altered in the CKD2 group when compared to CKD1 and the control group at T0. A total of seven serum metabolites differed after 60 days of the renal diet: glycine, fructose, glutamic acid, arachidonic acid, stearic acid, creatinine, and urea. Changes were seen in the serum metabolomic profile after 60 days of the renal diet, and some of the metabolites that changed in response to the diet have beneficial effects on health. Overall, metabolomics markers have the potential to identify early stages of CKD, providing insights into the possible pathophysiologic processes that contribute to the development and progression of CKD. |
References: | Anal Chim Acta. 2015 Nov 5;900:21-35. (PMID: 26572836) Vet Clin North Am Small Anim Pract. 2016 Nov;46(6):1067-94. (PMID: 27593575) Kidney Int. 1990 Jul;38(1):167-84. (PMID: 2200925) Vet Clin North Am Small Anim Pract. 2008 Jan;38(1):157-66, vi. (PMID: 18249247) N Engl J Med. 2006 Jun 8;354(23):2473-83. (PMID: 16760447) EBioMedicine. 2017 Dec;26:68-77. (PMID: 29128444) J Am Coll Nutr. 1989 Aug;8(4):310-23. (PMID: 2674258) Annu Rev Physiol. 1984;46:327-41. (PMID: 6370112) J Feline Med Surg. 2013 Sep;15 Suppl 1:3-14. (PMID: 23999182) Toxins (Basel). 2019 Dec 19;12(1):. (PMID: 31861622) J Biol Chem. 1947 Mar;167(3):855-60. (PMID: 20287919) J Lab Clin Med. 1998 May;131(5):447-55. (PMID: 9605110) J Vet Intern Med. 2019 Mar;33(2):662-669. (PMID: 30561098) J Nutr. 1995 Apr;125(4):1010-6. (PMID: 7722679) BMC Genomics. 2009 Aug 21;10:388. (PMID: 19698090) Sci Rep. 2018 Jun 4;8(1):8539. (PMID: 29867102) PLoS One. 2020 Jul 2;15(7):e0235480. (PMID: 32614877) J Feline Med Surg. 2018 Feb;20(2):155-163. (PMID: 28367722) Br J Nutr. 2011 Oct;106 Suppl 1:S57-9. (PMID: 22005437) Physiol Rep. 2016 May;4(9):. (PMID: 27162261) J Vet Emerg Crit Care (San Antonio). 2013 Mar-Apr;23(2):205-15. (PMID: 23470210) Int Urol Nephrol. 1994;26(6):707-12. (PMID: 7759208) Anal Chim Acta. 2011 Mar 9;689(1):85-91. (PMID: 21338761) Anal Chem. 2009 Dec 15;81(24):10038-48. (PMID: 19928838) JCI Insight. 2018 Aug 23;3(16):. (PMID: 30135309) Vet Rec. 2005 Aug 13;157(7):185-7. (PMID: 16100367) Am J Clin Nutr. 2005 Aug;82(2):342-9. (PMID: 16087977) PLoS One. 2014 Sep 05;9(9):e106647. (PMID: 25191961) J Am Vet Med Assoc. 2002 Apr 15;220(8):1163-70. (PMID: 11990962) Nat Med. 2015 Jan;21(1):37-46. (PMID: 25419705) Vet Res Commun. 2006 May;30(4):403-13. (PMID: 16502108) Biomolecules. 2021 Aug 24;11(9):. (PMID: 34572472) Ann Clin Biochem. 2007 Jan;44(Pt 1):35-42. (PMID: 17270090) Analyst. 2011 Mar 7;136(5):947-54. (PMID: 21157593) Front Microbiol. 2020 Jun 25;11:1266. (PMID: 32670224) Vet Sci. 2022 Feb 17;9(2):. (PMID: 35202337) Vet Pathol. 2016 Mar;53(2):309-26. (PMID: 26869151) Nat Rev Nephrol. 2011 Oct 25;8(1):22-33. (PMID: 22025087) Front Immunol. 2021 Jun 16;12:694457. (PMID: 34220855) J Appl Physiol Respir Environ Exerc Physiol. 1981 Sep;51(3):762-6. (PMID: 7327978) Anal Bioanal Chem. 2009 Jul;394(6):1517-24. (PMID: 19172251) Sci Rep. 2019 Jul 16;9(1):10252. (PMID: 31311955) Metabolites. 2021 Dec 06;11(12):. (PMID: 34940602) Am J Vet Res. 1984 Mar;45(3):506-17. (PMID: 6711979) Am J Physiol Renal Physiol. 2006 Feb;290(2):F262-72. (PMID: 16403839) J Vet Intern Med. 2014 Nov-Dec;28(6):1692-8. (PMID: 25273603) Physiol Rev. 2000 Jul;80(3):1107-213. (PMID: 10893433) Vet Clin North Am Small Anim Pract. 2011 Jan;41(1):15-30. (PMID: 21251509) Med Clin North Am. 2005 May;89(3):457-73. (PMID: 15755462) Vet Clin North Am Small Anim Pract. 2012 Jul;42(4):669-92, vi. (PMID: 22720808) Int J Mol Sci. 2019 Jul 27;20(15):. (PMID: 31357612) |
فهرسة مساهمة: | Keywords: chronic kidney disease; felines; metabolic profile; nutrition; renal disease; uremic toxins |
تواريخ الأحداث: | Date Created: 20230121 Latest Revision: 20230201 |
رمز التحديث: | 20240628 |
مُعرف محوري في PubMed: | PMC9863800 |
DOI: | 10.3390/metabo13010043 |
PMID: | 36676969 |
قاعدة البيانات: | MEDLINE |
تدمد: | 2218-1989 |
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DOI: | 10.3390/metabo13010043 |