دورية أكاديمية
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In Vitro Activity of Essential Oils from Piper Species (Piperaceae) against Tachyzoites of Toxoplasma gondii .

التفاصيل البيبلوغرافية
العنوان: In Vitro Activity of Essential Oils from Piper Species (Piperaceae) against Tachyzoites of Toxoplasma gondii .
المؤلفون: Pereira Filho AA; Departamento de Parasitologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, Minas Gerais, Brazil., Cunha MM; Departamento de Parasitologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, Minas Gerais, Brazil., Alves Stanton M; Department of Fundamental Chemistry, Institute of Chemistry, University of São Paulo, São Paulo 05508-000, São Paulo, Brazil., Fumiko Yamaguchi L; Department of Fundamental Chemistry, Institute of Chemistry, University of São Paulo, São Paulo 05508-000, São Paulo, Brazil., Jorge Kato M; Department of Fundamental Chemistry, Institute of Chemistry, University of São Paulo, São Paulo 05508-000, São Paulo, Brazil., Martins-Duarte ÉS; Departamento de Parasitologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, Minas Gerais, Brazil.
المصدر: Metabolites [Metabolites] 2023 Jan 06; Vol. 13 (1). Date of Electronic Publication: 2023 Jan 06.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101578790 Publication Model: Electronic Cited Medium: Print ISSN: 2218-1989 (Print) Linking ISSN: 22181989 NLM ISO Abbreviation: Metabolites Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Basel : MDPI
مستخلص: Toxoplasmosis is a tropical and neglected disease caused by the parasitic protozoa Toxplasma gondii . Conventional treatment with sulfadiazine and pyrimethamine plus folinic acid, has some drawbacks, such as inefficacy in the chronic phase, toxic side effects, and potential cases of resistance have been observed. In this study, the activity of essential oils (EOs) from three Piper species and their main constituents, including α-Pinene ( Piper lindbergii and P. cernuum ), β-Pinene ( P. cernuum ), and dillapiole ( P. aduncum ), were evaluated against tachyzoites of T. gondii . α-Pinene was more active [(IC 50 0.3265 (0.2958 to 0.3604) μg/mL)] against tachyzoites than P. lindbergii EO [0.8387 (0.6492 to 1.084) μg/mL]. Both α-Pinene and P. lindbergii EO exhibited low cytotoxicity against NHDF cells, with CC 50 41.37 (37.64 to 45.09) µg/mL and 83.80 (75.42 to 91.34) µg/mL, respectively, suggesting they could be of potential use against toxoplasmosis.
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معلومات مُعتمدة: 2014/50316-7 São Paulo Research Foundation; 09/2019 PRPq UFMG; fellowship for AAPF CAPES
فهرسة مساهمة: Keywords: Piper; essential oils; toxoplasmosis
تواريخ الأحداث: Date Created: 20230121 Latest Revision: 20230201
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC9861968
DOI: 10.3390/metabo13010095
PMID: 36677020
قاعدة البيانات: MEDLINE
الوصف
تدمد:2218-1989
DOI:10.3390/metabo13010095