دورية أكاديمية
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"Silicon-On-Insulator"-Based Biosensor for the Detection of MicroRNA Markers of Ovarian Cancer.

التفاصيل البيبلوغرافية
العنوان: "Silicon-On-Insulator"-Based Biosensor for the Detection of MicroRNA Markers of Ovarian Cancer.
المؤلفون: Ivanov YD; Institute of Biomedical Chemistry (IBMC), 119121 Moscow, Russia.; Joint Institute for High Temperatures of Russian Academy of Sciences, 125412 Moscow, Russia., Kapustina SI; Institute of Biomedical Chemistry (IBMC), 119121 Moscow, Russia.; Department of Cybernetics of Chemical and Technological Processes, Mendeleev University of Chemical Technology of Russia (MUCTR), 125047 Moscow, Russia., Malsagova KA; Institute of Biomedical Chemistry (IBMC), 119121 Moscow, Russia., Goldaeva KV; Institute of Biomedical Chemistry (IBMC), 119121 Moscow, Russia., Pleshakova TO; Institute of Biomedical Chemistry (IBMC), 119121 Moscow, Russia., Galiullin RA; Institute of Biomedical Chemistry (IBMC), 119121 Moscow, Russia., Shumov ID; Institute of Biomedical Chemistry (IBMC), 119121 Moscow, Russia., Kozlov AF; Institute of Biomedical Chemistry (IBMC), 119121 Moscow, Russia., Glukhov AV; JSC 'Novosibirsk Plant of Semiconductor Devices with OKB', 630082 Novosibirsk, Russia., Grabezhova VK; JSC 'Design Center for Biomicroelectronic Technologies 'Vega'', 630082 Novosibirsk, Russia., Popov VP; Rzhanov Institute of Semiconductor Physics, Siberian Branch of Russian Academy of Sciences, 630090 Novosibirsk, Russia., Petrov OF; Joint Institute for High Temperatures of Russian Academy of Sciences, 125412 Moscow, Russia., Ziborov VS; Institute of Biomedical Chemistry (IBMC), 119121 Moscow, Russia.; Joint Institute for High Temperatures of Russian Academy of Sciences, 125412 Moscow, Russia., Kushlinskii NE; N.N. Blokhin National Medical Research Center of Oncology, 115478 Moscow, Russia., Alferov AA; N.N. Blokhin National Medical Research Center of Oncology, 115478 Moscow, Russia., Konev VA; Department of Infectious Diseases in Children, Faculty of Pediatrics, Pirogov Russian National Research Medical University (RNRMU), 117997 Moscow, Russia., Kovalev OB; Department of Infectious Diseases in Children, Faculty of Pediatrics, Pirogov Russian National Research Medical University (RNRMU), 117997 Moscow, Russia., Uchaikin VF; Department of Infectious Diseases in Children, Faculty of Pediatrics, Pirogov Russian National Research Medical University (RNRMU), 117997 Moscow, Russia., Archakov AI; Institute of Biomedical Chemistry (IBMC), 119121 Moscow, Russia.
المصدر: Micromachines [Micromachines (Basel)] 2022 Dec 27; Vol. 14 (1). Date of Electronic Publication: 2022 Dec 27.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101640903 Publication Model: Electronic Cited Medium: Print ISSN: 2072-666X (Print) Linking ISSN: 2072666X NLM ISO Abbreviation: Micromachines (Basel) Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI, [2010]-
مستخلص: Ovarian cancer is a gynecological cancer characterized by a high mortality rate and tumor heterogeneity. Its early detection and primary prophylaxis are difficult to perform. Detecting biomarkers for ovarian cancer plays a pivotal role in therapy effectiveness and affects patients' survival. This study demonstrates the detection of microRNAs (miRNAs), which were reported to be associated with ovarian cancer tumorigenesis, with a nanowire biosensor based on silicon-on-insulator structures (SOI-NW biosensor). The advantages of the method proposed for miRNA detection using the SOI-NW biosensor are as follows: (1) no need for additional labeling or amplification reaction during sample preparation, and (2) real-time detection of target biomolecules. The detecting component of the biosensor is a chip with an array of 3 µm wide, 10 µm long silicon nanowires on its surface. The SOI-NW chip was fabricated using the "top-down" method, which is compatible with large-scale CMOS technology. Oligonucleotide probes (oDNA probes) carrying sequences complementary to the target miRNAs were covalently immobilized on the nanowire surface to ensure high-sensitivity biospecific sensing of the target biomolecules. The study involved two experimental series. Detection of model DNA oligonucleotides being synthetic analogs of the target miRNAs was carried out to assess the method's sensitivity. The lowest concentration of the target oligonucleotides detectable in buffer solution was 1.1 × 10 -16 M. In the second experimental series, detection of miRNAs (miRNA-21, miRNA-141, and miRNA-200a) isolated from blood plasma samples collected from patients having a verified diagnosis of ovarian cancer was performed. The results of our present study represent a step towards the development of novel highly sensitive diagnostic systems for the early revelation of ovarian cancer in women.
References: Cancer Lett. 2015 Jan 28;356(2 Pt B):628-36. (PMID: 25451316)
Anal Chim Acta. 2021 May 22;1160:338393. (PMID: 33894957)
Biosensors (Basel). 2021 Jan 17;11(1):. (PMID: 33477344)
Clin Transl Oncol. 2015 Oct;17(10):779-87. (PMID: 26063644)
Hematol Oncol Clin North Am. 2018 Dec;32(6):903-914. (PMID: 30390764)
Mol Biol Rep. 1993 Apr;17(3):167-83. (PMID: 8326953)
J Cell Physiol. 2018 May;233(5):3846-3854. (PMID: 28703277)
Nano Lett. 2007 Nov;7(11):3405-9. (PMID: 17914853)
Biosensors (Basel). 2020 Dec 18;10(12):. (PMID: 33353197)
Pathobiology. 2018;85(1-2):41-49. (PMID: 29020678)
Nat Protoc. 2008;3(2):190-6. (PMID: 18274520)
Sensors (Basel). 2018 May 18;18(5):. (PMID: 29783662)
Biosensors (Basel). 2021 Apr 12;11(4):. (PMID: 33921281)
Adv Exp Med Biol. 2020;1219:355-363. (PMID: 32130708)
J Cancer. 2019 Jan 1;10(2):441-448. (PMID: 30719138)
Int J Environ Res Public Health. 2019 Apr 29;16(9):. (PMID: 31035447)
Anal Methods. 2021 May 6;13(17):2021-2029. (PMID: 33956002)
Open Life Sci. 2021 Jun 02;16(1):558-570. (PMID: 34131589)
Sci Rep. 2020 Dec 8;10(1):21431. (PMID: 33293534)
Chem Soc Rev. 2015 May 21;44(10):2963-97. (PMID: 25739971)
Anal Biochem. 2019 Sep 15;581:113349. (PMID: 31254490)
Tumour Biol. 2015 Jun;36(6):4843-50. (PMID: 25636451)
Radiol Technol. 2020 Jul;91(6):561-575. (PMID: 32606233)
ACS Appl Mater Interfaces. 2020 Apr 8;12(14):16076-16087. (PMID: 32207913)
CA Cancer J Clin. 2022 Jan;72(1):7-33. (PMID: 35020204)
Biochim Biophys Acta Rev Cancer. 2021 Apr;1875(2):188503. (PMID: 33421585)
Biosens Bioelectron. 2009 Apr 15;24(8):2504-8. (PMID: 19188058)
Nucleic Acids Res. 2011 Dec;39(22):e154. (PMID: 21976734)
J Ovarian Res. 2022 Feb 19;15(1):27. (PMID: 35183243)
Biosensors (Basel). 2021 Jul 13;11(7):. (PMID: 34356707)
Proc Natl Acad Sci U S A. 2004 Sep 28;101(39):14017-22. (PMID: 15365183)
Asian Pac J Cancer Prev. 2013;14(2):1057-60. (PMID: 23621186)
Semin Oncol Nurs. 2019 Apr;35(2):151-156. (PMID: 30867104)
Biosensors (Basel). 2021 Sep 18;11(9):. (PMID: 34562936)
Drug Discov Today Technol. 2004 Dec;1(3):301-8. (PMID: 24981499)
Mikrochim Acta. 2022 May 5;189(6):213. (PMID: 35513513)
Exp Mol Pathol. 2020 Apr;113:104381. (PMID: 31954715)
Micromachines (Basel). 2021 Dec 18;12(12):. (PMID: 34945431)
Micromachines (Basel). 2018 Dec 19;9(12):. (PMID: 30572645)
Nucleic Acids Res. 2016 Sep 6;44(15):e130. (PMID: 27257058)
PLoS One. 2008 Jul 02;3(7):e2535. (PMID: 18596971)
PLoS One. 2012;7(7):e41561. (PMID: 22859996)
Nat Biotechnol. 2010 Jun;28(6):595-9. (PMID: 20495550)
Genes (Basel). 2022 Jan 22;13(2):. (PMID: 35205244)
Proteomics. 2014 Oct;14(20):2261-74. (PMID: 25044858)
Cells. 2020 Jan 23;9(2):. (PMID: 31979244)
Semin Oncol. 2011 Dec;38(6):721-3. (PMID: 22082757)
RNA. 2017 Jun;23(6):823-835. (PMID: 28289155)
Org Biomol Chem. 2015 Feb 28;13(8):2226-38. (PMID: 25574760)
Anal Chim Acta. 2012 Oct 24;749:1-15. (PMID: 23036462)
Biosens Bioelectron. 2014 Oct 15;60:101-11. (PMID: 24787124)
Biosens Bioelectron. 2018 Jan 15;99:525-546. (PMID: 28823978)
Anal Sci. 2021 Oct 10;37(10):1349-1353. (PMID: 33431737)
معلومات مُعتمدة: 075-15-2022-305 The Ministry of Science and Higher Education of the Russian Federation within the framework of the project on creation and development of world-class research centers "Digital Biodesign and Personalized Healthcare"
فهرسة مساهمة: Keywords: biomarkers; biosensor; miRNA; nanowire; oDNA; ovarian cancer; silicon-on-insulator
تواريخ الأحداث: Date Created: 20230121 Latest Revision: 20230201
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC9861449
DOI: 10.3390/mi14010070
PMID: 36677130
قاعدة البيانات: MEDLINE
الوصف
تدمد:2072-666X
DOI:10.3390/mi14010070