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Constituents of Pulicaria inuloides and Cytotoxic Activities of Two Methoxylated Flavonols.

التفاصيل البيبلوغرافية
العنوان: Constituents of Pulicaria inuloides and Cytotoxic Activities of Two Methoxylated Flavonols.
المؤلفون: Malarz J; Maj Institute of Pharmacology, Polish Academy of Sciences, Smętna Street 12, 31-343 Kraków, Poland., Michalska K; Maj Institute of Pharmacology, Polish Academy of Sciences, Smętna Street 12, 31-343 Kraków, Poland., Galanty A; Department of Pharmacognosy, Jagiellonian University Medical College, Medyczna Street 9, 30-688 Kraków, Poland., Kiss AK; Department of Pharmacognosy and Molecular Basis of Phytotherapy, Medical University of Warsaw, 1 Banacha Street, 02-097 Warsaw, Poland., Stojakowska A; Maj Institute of Pharmacology, Polish Academy of Sciences, Smętna Street 12, 31-343 Kraków, Poland.
المصدر: Molecules (Basel, Switzerland) [Molecules] 2023 Jan 04; Vol. 28 (2). Date of Electronic Publication: 2023 Jan 04.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049 (Electronic) Linking ISSN: 14203049 NLM ISO Abbreviation: Molecules Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI, c1995-
مواضيع طبية MeSH: Pulicaria*/chemistry , Methyl Ethers* , Antineoplastic Agents*, Humans ; Flavonols/pharmacology ; Plant Extracts/pharmacology ; Plant Extracts/chemistry
مستخلص: Plants of the genus Pulicaria are known for providing traditional medicines, spices, herbal teas, and insect deterrents. Pulicaria inuloides (Poir.). DC. is one of the less chemically studied species within the genus. Hydroalcoholic extracts from roots and aerial parts of P. inuloides were analyzed using the UHPLC-PAD-MSn technique and revealed the presence of six caffeoylquinic and eleven caffeoylhexaric conjugates together with hydroxykaempferol dimethyl ether and quercetagetin trimethyl ether. Moreover, constituents of chloroform extract from the whole P. inuloides plants were isolated and identified by spectroscopic methods. One new and four known caryophyllene derivatives, three thymol derivatives, and four polymethoxylated flavonols were found in the analyzed extract. The structure of the new compound was established by spectroscopic methods (HRESIMS, 1H NMR, 13C NMR, COSY, HSQC, HMBC, NOESY). The cytotoxicity of 6-Hydroxykaempferol 3,7-dimethyl ether and quercetagetin 3,7,3’-trimethyl ether (chrysosplenol C), which are major flavonols isolated from the plant, were tested on prostate epithelial cells (PNT2), prostate cancer cells (DU145 and PC3), human keratinocytes (HaCaT), and melanoma cells (HTB140 and A375). Both flavonols demonstrated moderate cytotoxic activity against PC3 cells (IC50 = 59.5 µM and 46.6 µM, respectively). The remaining cell lines were less affected (IC50 > 150 µM).
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فهرسة مساهمة: Keywords: caffeic acid derivatives; caffeoylhexaric acids; caryopyllene derivatives; cytotoxicity; polymethoxylated flavonols; thymol derivatives
المشرفين على المادة: 0 (Flavonols)
AM13FS69BX (dimethyl ether)
0 (Methyl Ethers)
0 (Antineoplastic Agents)
0 (Plant Extracts)
تواريخ الأحداث: Date Created: 20230121 Date Completed: 20230124 Latest Revision: 20230308
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC9866601
DOI: 10.3390/molecules28020480
PMID: 36677535
قاعدة البيانات: MEDLINE
الوصف
تدمد:1420-3049
DOI:10.3390/molecules28020480