دورية أكاديمية
Determination of Chemical Composition and Investigation of Biological Activities of Ocimum basilicum L.
العنوان: | Determination of Chemical Composition and Investigation of Biological Activities of Ocimum basilicum L. |
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المؤلفون: | Qasem A; Department of Laboratory Medicine, Faculty of Applied Medical Sciences, Umm Al-Qura University, Makkah 21955, Saudi Arabia., Assaggaf H; Department of Laboratory Medicine, Faculty of Applied Medical Sciences, Umm Al-Qura University, Makkah 21955, Saudi Arabia., Mrabti HN; Laboratoires TBC, Faculty of Pharmaceutical and Biological Sciences, B.P. 8359006 Lille, France., Minshawi F; Department of Laboratory Medicine, Faculty of Applied Medical Sciences, Umm Al-Qura University, Makkah 21955, Saudi Arabia., Rajab BS; Department of Laboratory Medicine, Faculty of Applied Medical Sciences, Umm Al-Qura University, Makkah 21955, Saudi Arabia., Attar AA; Department of Laboratory Medicine, Faculty of Applied Medical Sciences, Umm Al-Qura University, Makkah 21955, Saudi Arabia., Alyamani RA; Faculty of Applied Medical Sciences, Clinical Nutrition Department, Umm Al-Qura University, Makkah 24381, Saudi Arabia., Hamed M; Department of Pathology, Faculty of Medicine, Umm Al-Qura University, Makkah 21955, Saudi Arabia., Mrabti NN; Engineering Materials, Modeling and Environmental Laboratory, Faculty of Sciences Dhar El Mehraz, Sidi Mohammed Ben Abdellah University, Fez 30000, Morocco., Baaboua AE; Biology and Health Laboratory, Department of Biology, Faculty of Science, Abdelmalek-Essaadi University, Tetouan 93000, Morocco., Omari NE; Laboratory of Histology, Embryology and Cytogenetic, Faculty of Medicine and Pharmacy, Mohammed V University in Rabat, Rabat 10100, Morocco., Alshahrani MM; Department of Clinical Laboratory Sciences, Faculty of Applied Medical Sciences, Najran University, P.O. Box 1988, Najran 61441, Saudi Arabia., Awadh AAA; Department of Clinical Laboratory Sciences, Faculty of Applied Medical Sciences, Najran University, P.O. Box 1988, Najran 61441, Saudi Arabia., Sheikh RA; Biochemistry Department, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia., Ming LC; School of Medical and Life Sciences, Sunway University, Bandar Sunway 47500, Malaysia., Goh KW; Faculty of Data Science and Information Technology, INTI International University, Nilai 71800, Malaysia., Bouyahya A; Laboratory of Human Pathologies Biology, Department of Biology, Faculty of Sciences, Mohammed V University in Rabat, Rabat 10100, Morocco. |
المصدر: | Molecules (Basel, Switzerland) [Molecules] 2023 Jan 06; Vol. 28 (2). Date of Electronic Publication: 2023 Jan 06. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049 (Electronic) Linking ISSN: 14203049 NLM ISO Abbreviation: Molecules Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: Basel, Switzerland : MDPI, c1995- |
مواضيع طبية MeSH: | Ocimum basilicum*/chemistry , Oils, Volatile*/pharmacology , Oils, Volatile*/chemistry, Monophenol Monooxygenase ; alpha-Glucosidases ; Anti-Bacterial Agents/pharmacology ; Anti-Inflammatory Agents/pharmacology ; Lipoxygenases |
مستخلص: | This study aimed to determine the chemical composition of the essential oils (EOs) of Ocimum basilicum L., as well as to evaluate the antibacterial, antidiabetic, dermatoprotective, and anti-inflammatory properties, and the EOs and aqueous extracts of O. basilicum . The antibacterial activity was evaluated against bacterial strains, Gram-positive and Gram-negative, using the well diffusion and microdilution methods, whereas the antidiabetic activity was assessed in vitro using two enzymes involved in carbohydrate digestion, α-amylase and α-glucosidase. On the other hand, the dermatoprotective and anti-inflammatory activities were studied by testing tyrosinase and lipoxygenase inhibition activity, respectively. The results showed that the chemical composition of O. basilicum EO (OBEO) is dominated by methyl chavicol (86%) and trans -anethol (8%). OBEO exhibited significant antibacterial effects against Gram-negative and Gram-positive strains, demonstrated by considerable diameters of the inhibition zones and lower MIC and MBC values. In addition, OBEO exhibited significant inhibition of α-amylase (IC |
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فهرسة مساهمة: | Keywords: aromatherapy; basil; biological properties; biomedicine; cosmetology; essential oils |
المشرفين على المادة: | 9NIW07V3ET (estragole) EC 1.14.18.1 (Monophenol Monooxygenase) EC 3.2.1.20 (alpha-Glucosidases) 0 (Oils, Volatile) 0 (Anti-Bacterial Agents) 0 (Anti-Inflammatory Agents) EC 1.13.11.- (Lipoxygenases) |
تواريخ الأحداث: | Date Created: 20230121 Date Completed: 20230124 Latest Revision: 20230918 |
رمز التحديث: | 20230918 |
مُعرف محوري في PubMed: | PMC9866482 |
DOI: | 10.3390/molecules28020614 |
PMID: | 36677672 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1420-3049 |
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DOI: | 10.3390/molecules28020614 |