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Determination of Chemical Composition and Investigation of Biological Activities of Ocimum basilicum L.

التفاصيل البيبلوغرافية
العنوان: Determination of Chemical Composition and Investigation of Biological Activities of Ocimum basilicum L.
المؤلفون: Qasem A; Department of Laboratory Medicine, Faculty of Applied Medical Sciences, Umm Al-Qura University, Makkah 21955, Saudi Arabia., Assaggaf H; Department of Laboratory Medicine, Faculty of Applied Medical Sciences, Umm Al-Qura University, Makkah 21955, Saudi Arabia., Mrabti HN; Laboratoires TBC, Faculty of Pharmaceutical and Biological Sciences, B.P. 8359006 Lille, France., Minshawi F; Department of Laboratory Medicine, Faculty of Applied Medical Sciences, Umm Al-Qura University, Makkah 21955, Saudi Arabia., Rajab BS; Department of Laboratory Medicine, Faculty of Applied Medical Sciences, Umm Al-Qura University, Makkah 21955, Saudi Arabia., Attar AA; Department of Laboratory Medicine, Faculty of Applied Medical Sciences, Umm Al-Qura University, Makkah 21955, Saudi Arabia., Alyamani RA; Faculty of Applied Medical Sciences, Clinical Nutrition Department, Umm Al-Qura University, Makkah 24381, Saudi Arabia., Hamed M; Department of Pathology, Faculty of Medicine, Umm Al-Qura University, Makkah 21955, Saudi Arabia., Mrabti NN; Engineering Materials, Modeling and Environmental Laboratory, Faculty of Sciences Dhar El Mehraz, Sidi Mohammed Ben Abdellah University, Fez 30000, Morocco., Baaboua AE; Biology and Health Laboratory, Department of Biology, Faculty of Science, Abdelmalek-Essaadi University, Tetouan 93000, Morocco., Omari NE; Laboratory of Histology, Embryology and Cytogenetic, Faculty of Medicine and Pharmacy, Mohammed V University in Rabat, Rabat 10100, Morocco., Alshahrani MM; Department of Clinical Laboratory Sciences, Faculty of Applied Medical Sciences, Najran University, P.O. Box 1988, Najran 61441, Saudi Arabia., Awadh AAA; Department of Clinical Laboratory Sciences, Faculty of Applied Medical Sciences, Najran University, P.O. Box 1988, Najran 61441, Saudi Arabia., Sheikh RA; Biochemistry Department, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia., Ming LC; School of Medical and Life Sciences, Sunway University, Bandar Sunway 47500, Malaysia., Goh KW; Faculty of Data Science and Information Technology, INTI International University, Nilai 71800, Malaysia., Bouyahya A; Laboratory of Human Pathologies Biology, Department of Biology, Faculty of Sciences, Mohammed V University in Rabat, Rabat 10100, Morocco.
المصدر: Molecules (Basel, Switzerland) [Molecules] 2023 Jan 06; Vol. 28 (2). Date of Electronic Publication: 2023 Jan 06.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049 (Electronic) Linking ISSN: 14203049 NLM ISO Abbreviation: Molecules Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI, c1995-
مواضيع طبية MeSH: Ocimum basilicum*/chemistry , Oils, Volatile*/pharmacology , Oils, Volatile*/chemistry, Monophenol Monooxygenase ; alpha-Glucosidases ; Anti-Bacterial Agents/pharmacology ; Anti-Inflammatory Agents/pharmacology ; Lipoxygenases
مستخلص: This study aimed to determine the chemical composition of the essential oils (EOs) of Ocimum basilicum L., as well as to evaluate the antibacterial, antidiabetic, dermatoprotective, and anti-inflammatory properties, and the EOs and aqueous extracts of O. basilicum . The antibacterial activity was evaluated against bacterial strains, Gram-positive and Gram-negative, using the well diffusion and microdilution methods, whereas the antidiabetic activity was assessed in vitro using two enzymes involved in carbohydrate digestion, α-amylase and α-glucosidase. On the other hand, the dermatoprotective and anti-inflammatory activities were studied by testing tyrosinase and lipoxygenase inhibition activity, respectively. The results showed that the chemical composition of O. basilicum EO (OBEO) is dominated by methyl chavicol (86%) and trans -anethol (8%). OBEO exhibited significant antibacterial effects against Gram-negative and Gram-positive strains, demonstrated by considerable diameters of the inhibition zones and lower MIC and MBC values. In addition, OBEO exhibited significant inhibition of α-amylase (IC 50 = 50.51 ± 0.32 μg/mL) and α-glucosidase (IC 50 = 39.84 ± 1.2 μg/mL). Concerning the anti-inflammatory activity, OBEO significantly inhibited lipoxygenase activity (IC 50 = 18.28 ± 0.03 μg/mL) compared to the aqueous extract (IC 50 = 24.8 ± 0.01 μg/mL). Moreover, tyrosinase was considerably inhibited by OBEO (IC 50 = 68.58 ± 0.03 μg/mL) compared to the aqueous extract (IC 50 = 118.37 ± 0.05 μg/mL). The toxicological investigations revealed the safety of O. basilicum in acute and chronic toxicity. The finding of in silico analysis showed that methyl chavicol and trans -anethole (main compounds of OBEO) validate the pharmacokinetics of these compounds and decipher some antibacterial targets.
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فهرسة مساهمة: Keywords: aromatherapy; basil; biological properties; biomedicine; cosmetology; essential oils
المشرفين على المادة: 9NIW07V3ET (estragole)
EC 1.14.18.1 (Monophenol Monooxygenase)
EC 3.2.1.20 (alpha-Glucosidases)
0 (Oils, Volatile)
0 (Anti-Bacterial Agents)
0 (Anti-Inflammatory Agents)
EC 1.13.11.- (Lipoxygenases)
تواريخ الأحداث: Date Created: 20230121 Date Completed: 20230124 Latest Revision: 20230918
رمز التحديث: 20230918
مُعرف محوري في PubMed: PMC9866482
DOI: 10.3390/molecules28020614
PMID: 36677672
قاعدة البيانات: MEDLINE
الوصف
تدمد:1420-3049
DOI:10.3390/molecules28020614