دورية أكاديمية
Feature-Based Molecular Networking for the Exploration of the Metabolome Diversity of Common Egyptian Centaurea Species in Relation to Their Cytotoxic Activity.
العنوان: | Feature-Based Molecular Networking for the Exploration of the Metabolome Diversity of Common Egyptian Centaurea Species in Relation to Their Cytotoxic Activity. |
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المؤلفون: | Reda EH; Phytochemistry Laboratory, National Organization for Drug Control and Research, Giza 12622, Egypt., Hegazi NM; Phytochemistry and Plant Systematics Department, National Research Centre, Dokki, Cairo 12622, Egypt., Marzouk M; Phytochemistry and Plant Systematics Department, National Research Centre, Dokki, Cairo 12622, Egypt., Shakour ZTA; Phytochemistry Laboratory, National Organization for Drug Control and Research, Giza 12622, Egypt., El-Halawany AM; Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt., El-Kashoury EA; Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt., Mohamed TA; Chemistry of Medicinal Plants Department, National Research Centre, 33 El-Bohouth St., Dokki, Giza 12622, Egypt., Ibrahim MAA; Computational Chemistry Laboratory, Chemistry Department, Faculty of Science, Minia University, Minia 61519, Egypt.; School of Health Sciences, University of Kwa-Zulu-Natal, Westville, Durban 4000, South Africa., Shams KA; Chemistry of Medicinal Plants Department, National Research Centre, 33 El-Bohouth St., Dokki, Giza 12622, Egypt., Abdel-Azim NS; Chemistry of Medicinal Plants Department, National Research Centre, 33 El-Bohouth St., Dokki, Giza 12622, Egypt., Kampf CJ; Department for Chemistry, Johannes Gutenberg University Mainz, Duesbergweg 10-14, 55128 Mainz, Germany., Efferth T; Department of Pharmaceutical Biology, Institute of Pharmaceutical and Biomedical Sciences Chemistry, Johannes Gutenberg University, Staudinger Weg 5, 55128 Mainz, Germany., Paré PW; Department of Chemistry & Biochemistry, Texas Tech University, Lubbock, TX 79409, USA., Hegazy MF; Chemistry of Medicinal Plants Department, National Research Centre, 33 El-Bohouth St., Dokki, Giza 12622, Egypt. |
المصدر: | Molecules (Basel, Switzerland) [Molecules] 2023 Jan 09; Vol. 28 (2). Date of Electronic Publication: 2023 Jan 09. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049 (Electronic) Linking ISSN: 14203049 NLM ISO Abbreviation: Molecules Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: Basel, Switzerland : MDPI, c1995- |
مواضيع طبية MeSH: | Antineoplastic Agents* , Centaurea*/chemistry , Sesquiterpenes*/chemistry, Plant Extracts/chemistry ; Chromatography, Liquid ; Drug Resistance, Multiple ; Egypt ; Drug Resistance, Neoplasm ; Tandem Mass Spectrometry ; Phytochemicals/pharmacology ; Lactones/chemistry |
مستخلص: | Centaurea is a genus compromising over 250 herbaceous flowering species and is used traditionally to treat several ailments. Among the Egyptian Centaurea species, C. lipii was reported to be cytotoxic against multidrug-resistant cancer cells. In this context, we aimed to explore the metabolome of C. lipii and compare it to other members of the genus in pursuance of identifying its bioactive principles. An LC-MS/MS analysis approach synchronized with feature-based molecular networks was adopted to offer a holistic overview of the metabolome diversity of the Egyptian Centaurea species. The studied plants included C. alexandrina, C. calcitrapa, C. eryngioides, C. glomerata, C. lipii, C. pallescens, C. pumilio, and C. scoparia . Their constitutive metabolome showed diverse chemical classes such as cinnamic acids, sesquiterpene lactones, flavonoids, and lignans. Linking the recorded metabolome to the previously reported cytotoxicity identified sesquiterpene lactones as the major contributors to this activity. To confirm our findings, bioassay-guided fractionation of C. lipii was adopted and led to the isolation of the sesquiterpene lactone cynaropicrin with an IC |
References: | Fitoterapia. 2017 Jul;120:98-102. (PMID: 28579551) J Nat Prod. 2012 Jul 27;75(7):1359-64. (PMID: 22775441) Carbohydr Res. 2010 Nov 22;345(17):2529-33. (PMID: 20937505) Arch Pharm Res. 2013 Oct;36(10):1223-30. (PMID: 23444043) Nat Biotechnol. 2016 Aug 9;34(8):828-837. (PMID: 27504778) Int J Cancer. 2013 Jan 15;132(2):308-14. (PMID: 22700458) Phytomedicine. 2021 Jan;81:153409. (PMID: 33341310) BMC Bioinformatics. 2010 Jul 23;11:395. (PMID: 20650010) Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2021 Jun;38(6):978-996. (PMID: 33861158) Phytochemistry. 2001 Dec;58(8):1229-33. (PMID: 11738413) Phytochemistry. 2013 Jun;90:90-4. (PMID: 23522933) Med Chem. 2017;13(5):498-502. (PMID: 27991400) Food Chem. 2023 Mar 15;404(Pt B):134650. (PMID: 36283320) J Nat Prod. 2005 Sep;68(9):1404-7. (PMID: 16180824) Chem Pharm Bull (Tokyo). 2005 Nov;53(11):1416-22. (PMID: 16272724) J Nat Prod. 2006 Apr;69(4):616-20. (PMID: 16643038) Metabolites. 2019 Jul 16;9(7):. (PMID: 31315242) J Nat Prod. 2019 Apr 26;82(4):919-927. (PMID: 30869892) Nat Prod Res. 2017 May;31(10):1195-1200. (PMID: 27609488) Molecules. 2021 Dec 09;26(24):. (PMID: 34946551) Int J Mol Sci. 2017 Nov 30;18(12):. (PMID: 29189749) J Cheminform. 2016 Feb 01;8:5. (PMID: 26839597) RSC Adv. 2021 Jun 4;11(33):20151-20163. (PMID: 35479905) ScientificWorldJournal. 2014;2014:274207. (PMID: 25114960) Phytother Res. 2021 Mar;35(3):1432-1442. (PMID: 33058354) Phytother Res. 2013 Apr;27(4):540-4. (PMID: 22674731) Phytochemistry. 2000 Dec;55(8):903-8. (PMID: 11140522) Phytomedicine. 2019 Jun;59:152771. (PMID: 31055230) Molecules. 2019 Aug 30;24(17):. (PMID: 31480332) J Med Chem. 1971 Dec;14(12):1147-52. (PMID: 5116225) Nat Prod Res. 2019 Nov;33(21):3070-3076. (PMID: 30445872) Fitoterapia. 2019 Mar;133:51-55. (PMID: 30557599) Biomolecules. 2020 Jul 04;10(7):. (PMID: 32635587) Pharm Biol. 2011 Aug;49(8):840-9. (PMID: 21612369) J Nat Prod. 2008 May;71(5):847-51. (PMID: 18393461) Sci Rep. 2016 Nov 08;6:36754. (PMID: 27824156) J Nat Prod. 2007 Nov;70(11):1796-9. (PMID: 17979247) J Nat Prod. 2007 May;70(5):830-4. (PMID: 17432904) Chem Biodivers. 2017 Sep;14(9):. (PMID: 28591430) Nat Prod Res. 2012;26(3):203-8. (PMID: 21815723) J Agric Food Chem. 2017 Jan 18;65(2):364-372. (PMID: 28008757) Evid Based Complement Alternat Med. 2021 Jul 05;2021:5587938. (PMID: 34285703) Int J Mol Sci. 2021 Oct 03;22(19):. (PMID: 34639057) Antibiotics (Basel). 2021 Mar 03;10(3):. (PMID: 33802470) Phytochemistry. 2001 Jun;57(4):559-64. (PMID: 11394857) |
فهرسة مساهمة: | Keywords: Centaurea; LC-MS/MS; cytotoxicity; molecular networking; sesquiterpene lactones |
المشرفين على المادة: | 0 (Plant Extracts) 0 (Antineoplastic Agents) 0 (Phytochemicals) 0 (Sesquiterpenes) 0 (Lactones) |
تواريخ الأحداث: | Date Created: 20230121 Date Completed: 20230124 Latest Revision: 20230124 |
رمز التحديث: | 20231215 |
مُعرف محوري في PubMed: | PMC9862008 |
DOI: | 10.3390/molecules28020674 |
PMID: | 36677732 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1420-3049 |
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DOI: | 10.3390/molecules28020674 |