دورية أكاديمية
أعرض في EDS

Hepatoprotective Effect of Curcumin Nano-Lipid Carrier against Cypermethrin Toxicity by Countering the Oxidative, Inflammatory, and Apoptotic Changes in Wistar Rats.

التفاصيل البيبلوغرافية
العنوان: Hepatoprotective Effect of Curcumin Nano-Lipid Carrier against Cypermethrin Toxicity by Countering the Oxidative, Inflammatory, and Apoptotic Changes in Wistar Rats.
المؤلفون: Hussain S; Department of Pharmacology and Toxicology, College of Pharmacy, Jazan University, Jazan 82817, Saudi Arabia., Ashafaq M; Department of Pharmacology and Toxicology, College of Pharmacy, Jazan University, Jazan 82817, Saudi Arabia., Alshahrani S; Department of Pharmacology and Toxicology, College of Pharmacy, Jazan University, Jazan 82817, Saudi Arabia., Bokar IAM; Pharmaceutical Science in Applied Toxicology, College of Pharmacy, Jazan University, Jazan 82817, Saudi Arabia., Siddiqui R; Department of Pharmacology and Toxicology, College of Pharmacy, Jazan University, Jazan 82817, Saudi Arabia., Alam MI; Department of Pharmaceutics, College of Pharmacy, Jazan University, Jazan 82817, Saudi Arabia., Taha MME; Substance Abuse Research Center (SARC), College of Pharmacy, Jazan University, Jazan 82817, Saudi Arabia., Almoshari Y; Department of Pharmaceutics, College of Pharmacy, Jazan University, Jazan 82817, Saudi Arabia., Alqahtani SS; Clinical Pharmacy Department, College of Pharmacy, Jazan University, Jazan 82817, Saudi Arabia.; Pharmacy Practice Research Unit, College of Pharmacy, Jazan University, Jazan 82817, Saudi Arabia., Ahmed RA; Department of Pharmacology and Toxicology, College of Pharmacy, Jazan University, Jazan 82817, Saudi Arabia., Jali AM; Department of Pharmacology and Toxicology, College of Pharmacy, Jazan University, Jazan 82817, Saudi Arabia., Qadri M; Department of Pharmacology and Toxicology, College of Pharmacy, Jazan University, Jazan 82817, Saudi Arabia.
المصدر: Molecules (Basel, Switzerland) [Molecules] 2023 Jan 16; Vol. 28 (2). Date of Electronic Publication: 2023 Jan 16.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049 (Electronic) Linking ISSN: 14203049 NLM ISO Abbreviation: Molecules Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI, c1995-
مواضيع طبية MeSH: Curcumin*/pharmacology , Curcumin*/metabolism , Chemical and Drug Induced Liver Injury*/drug therapy , Chemical and Drug Induced Liver Injury*/prevention & control , Chemical and Drug Induced Liver Injury*/metabolism, Rats ; Male ; Animals ; Rats, Wistar ; Oxidative Stress ; NF-kappa B/metabolism ; bcl-2-Associated X Protein/metabolism ; Interleukin-6/metabolism ; Tumor Necrosis Factor-alpha/metabolism ; Antioxidants/metabolism ; Liver
مستخلص: This study investigated the potential hepatoprotective activity of curcumin-incorporated nano-lipid carrier (Cur-NLC) against cypermethrin (Cyp) toxicity in adult Wistar male rats. All animals in groups III, IV, V, and VI were subjected to Cyp (50 mg/kg) toxicity for 15 days. Three different doses of Cur-NLC (1, 2.5, and 5 mg/kg/day) were administered orally for 10 days. The toxic effects were evaluated considering the increases in serum hepatic biomarkers alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), total protein and albumin, and lipid peroxidation (LPO), as well as a decrease in antioxidative activity (reduced glutathione (GSH), superoxide dismutase (SOD), and catalase) and the upregulation of inflammatory cytokines (IL-1β, IL-6, and TNF-α). Immunohistochemistry studies of proteins (NF-κB, Apaf-1, 4-HNE, and Bax) showed enhanced expression, and histopathological examination revealed architectural changes in liver cells, indicating liver toxicity in animals. Toxicity was determined by quantitative and qualitative determinations of DNA fragmentation, which show massive apoptosis with Cyp treatment. The administration of Cur-NLC significantly ameliorates all changes caused by Cyp, such as a decrease in the levels of serum liver markers, an increase in antioxidative parameters, a decrease in expression of inflammatory cytokines (IL-1β, IL-6, TNF-α, and NF-κB), and apoptosis (caspases-3, 9, Apaf-1, 4-HNE, and Bax), according to calorimetric and immunohistochemistry studies. The smear-like pattern of DNA is ameliorated similarly to the control at a high dose of Cur-NLC. Furthermore, all histopathological changes were reduced to a level close to the control. In conclusion, Cur-NLC could be a potent nutraceutical that exhibits a hepatoprotective effect against Cyp-induced hepatotoxicity in rats.
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فهرسة مساهمة: Keywords: curcumin; cypermethrin; hepatotoxicity; inflammatory cytokines; oxidative stress
المشرفين على المادة: IT942ZTH98 (Curcumin)
1TR49121NP (cypermethrin)
0 (NF-kappa B)
0 (bcl-2-Associated X Protein)
0 (Interleukin-6)
0 (Tumor Necrosis Factor-alpha)
0 (Antioxidants)
تواريخ الأحداث: Date Created: 20230121 Date Completed: 20230124 Latest Revision: 20230201
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC9864069
DOI: 10.3390/molecules28020881
PMID: 36677938
قاعدة البيانات: MEDLINE
الوصف
تدمد:1420-3049
DOI:10.3390/molecules28020881