دورية أكاديمية

A cohort study of wastewater treatment plant workers: Association between levels of biomarkers of systemic inflammation and exposure to bacteria and fungi, and endotoxin as measured using two methods.

التفاصيل البيبلوغرافية
العنوان: A cohort study of wastewater treatment plant workers: Association between levels of biomarkers of systemic inflammation and exposure to bacteria and fungi, and endotoxin as measured using two methods.
المؤلفون: Madsen AM; National Research Centre for the Working Environment, Lersø Parkallé 105, DK-2100, Copenhagen, Denmark. Electronic address: amm@nrcwe.dk., Uhrbrand K; National Research Centre for the Working Environment, Lersø Parkallé 105, DK-2100, Copenhagen, Denmark., Kofoed VC; National Research Centre for the Working Environment, Lersø Parkallé 105, DK-2100, Copenhagen, Denmark., Fischer TK; Dept of Clinical Research, Nordsjaellands Hospital, Denmark; Dept of Virus & Microbiological Special Diagnostics, Statens Serum Institut, Denmark., Frederiksen MW; National Research Centre for the Working Environment, Lersø Parkallé 105, DK-2100, Copenhagen, Denmark.
المصدر: Water research [Water Res] 2023 Mar 01; Vol. 231, pp. 119625. Date of Electronic Publication: 2023 Jan 16.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Pergamon Press Country of Publication: England NLM ID: 0105072 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-2448 (Electronic) Linking ISSN: 00431354 NLM ISO Abbreviation: Water Res Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Oxford, Pergamon Press.
مواضيع طبية MeSH: Occupational Exposure*/analysis , Air Pollutants, Occupational*/analysis , Water Purification*, Humans ; Endotoxins ; Cohort Studies ; Environmental Monitoring/methods ; Bacteria ; Biomarkers ; Inflammation ; Air Microbiology ; Fungi ; Dust/analysis
مستخلص: Work in wastewater treatment plants (WWTPs) can be associated with exposure to airborne microorganisms and endotoxin from the working environment. The aim of this study was to obtain knowledge about whether serum levels of the markers of systemic inflammation, C-reactive protein (CRP) and serum amyloid A (SAA), are associated with personal exposure to endotoxin, measured using the Limulus (endotoxin Limulus ) and the rFC (endotoxin rFC ) assays, as well as bacteria and fungi in a cohort of WWTP workers. Exposure and blood samples were collected for 11 workers over one year. Exposure to endotoxin Limulus-day and endotoxin rFC-day correlated significantly (r = 0.80, p<0.0001, n = 104), but endotoxin Limulus-day was 4.4 (Geometric mean (GM) value) times higher than endotoxin rFC-day (p<0.0001). The endotoxin Limulus-day , endotoxin rFC-day , bacteria, and fungal exposure as well as serum levels of CRP -day (GM=1.4 mg/l) and SAA -day (GM=12 mg/l) differed between workers. Serum levels of SAA day correlated significantly with CRP day (r = 0.30, p = 0.0068). The serum levels of CRP day were associated significantly with exposure to endotoxin Limulus-day . Exposure, SAA and CRP data were also analyzed as av. of each season, and SAA season was associated positively and significantly with endotoxin Limulus-season and endotoxin rFC-season and negatively with fungal season exposure. In conclusion, CRP day was associated with the endotoxin Limulus-day and SAA season with endotoxin Limulus-season and endotoxin rFC-season exposure. Thus, we hereby document that WWTP workers are exposed to airborne endotoxin which seems to have a negative impact on their health.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2023 The Author(s). Published by Elsevier Ltd.. All rights reserved.)
فهرسة مساهمة: Keywords: Inflammation; LPS; MALDI-TOF MS; Occupational exposure; Occupational exposure limit; Wastewater
المشرفين على المادة: 0 (Endotoxins)
0 (Air Pollutants, Occupational)
0 (Biomarkers)
0 (Dust)
تواريخ الأحداث: Date Created: 20230121 Date Completed: 20230210 Latest Revision: 20230210
رمز التحديث: 20240513
DOI: 10.1016/j.watres.2023.119625
PMID: 36680819
قاعدة البيانات: MEDLINE
الوصف
تدمد:1879-2448
DOI:10.1016/j.watres.2023.119625