دورية أكاديمية
Good and evil, more reasons to study UPR.
| العنوان: | Good and evil, more reasons to study UPR. |
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| المؤلفون: | Inagi R; Division of CKD Pathophysiology, The University of Tokyo, Graduate School of Medicine, Tokyo, Japan. Electronic address: inagi-r@m.u-tokyo.ac.jp., Hasegawa S; Division of CKD Pathophysiology, The University of Tokyo, Graduate School of Medicine, Tokyo, Japan. |
| المصدر: | Kidney international [Kidney Int] 2023 Feb; Vol. 103 (2), pp. 254-256. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't; Comment |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: United States NLM ID: 0323470 Publication Model: Print Cited Medium: Internet ISSN: 1523-1755 (Electronic) Linking ISSN: 00852538 NLM ISO Abbreviation: Kidney Int Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2016- : New York : Elsevier Original Publication: New York, Springer-Verlag. |
| مواضيع طبية MeSH: | Unfolded Protein Response* , Kidney Diseases*/therapy, Humans ; Kidney ; Homeostasis ; Endoplasmic Reticulum Stress |
| مستخلص: | The unfolded protein response (UPR) pathway, launched by endoplasmic reticulum, maintains endoplasmic reticulum homeostasis. Dysregulated UPR pathway links disease phenotypes, such as proteinuria, inflammation, and fibrosis, in kidney disease. Although accumulating evidence indicates the beneficial impact of the UPR pathway as a therapeutic target for various diseases, including kidney disease, the control of adaptive UPR status is still difficult for disease treatment. This article may give us a new insight into the strategy for sustaining the kidney protective UPR pathway. (Copyright © 2022 International Society of Nephrology. Published by Elsevier Inc. All rights reserved.) |
| التعليقات: | Comment on: Kidney Int. 2023 Feb;103(2):304-319. (PMID: 36309126) |
| تواريخ الأحداث: | Date Created: 20230121 Date Completed: 20230124 Latest Revision: 20231122 |
| رمز التحديث: | 20231122 |
| DOI: | 10.1016/j.kint.2022.09.015 |
| PMID: | 36681453 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1523-1755 |
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| DOI: | 10.1016/j.kint.2022.09.015 |