دورية أكاديمية
أعرض في EDS

Loss of CAMK2G affects intrinsic and motor behavior but has minimal impact on cognitive behavior.

التفاصيل البيبلوغرافية
العنوان: Loss of CAMK2G affects intrinsic and motor behavior but has minimal impact on cognitive behavior.
المؤلفون: Rigter PMF; Department of Clinical Genetics, Erasmus Medical Center, Rotterdam, Netherlands.; Erfelijke Neuro-Cognitieve Ontwikkelingsstoornissen, Expertise Centre for Neurodevelopmental Disorders, Erasmus Medical Center, Rotterdam, Netherlands., de Konink C; Erfelijke Neuro-Cognitieve Ontwikkelingsstoornissen, Expertise Centre for Neurodevelopmental Disorders, Erasmus Medical Center, Rotterdam, Netherlands.; Department of Neuroscience, Erasmus Medical Center, Rotterdam, Netherlands., van Woerden GM; Department of Clinical Genetics, Erasmus Medical Center, Rotterdam, Netherlands.; Erfelijke Neuro-Cognitieve Ontwikkelingsstoornissen, Expertise Centre for Neurodevelopmental Disorders, Erasmus Medical Center, Rotterdam, Netherlands.; Department of Neuroscience, Erasmus Medical Center, Rotterdam, Netherlands.
المصدر: Frontiers in neuroscience [Front Neurosci] 2023 Jan 06; Vol. 16, pp. 1086994. Date of Electronic Publication: 2023 Jan 06 (Print Publication: 2022).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Frontiers Research Foundation Country of Publication: Switzerland NLM ID: 101478481 Publication Model: eCollection Cited Medium: Print ISSN: 1662-4548 (Print) Linking ISSN: 1662453X NLM ISO Abbreviation: Front Neurosci Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Lausanne : Frontiers Research Foundation
مستخلص: Introduction: The gamma subunit of calcium/calmodulin-dependent protein kinase 2 (CAMK2G) is expressed throughout the brain and is associated with neurodevelopmental disorders. Research on the role of CAMK2G is limited and attributes different functions to specific cell types.
Methods: To further expand on the role of CAMK2G in brain functioning, we performed extensive phenotypic characterization of a Camk2g knockout mouse.
Results: We found different CAMK2G isoforms that show a distinct spatial expression pattern in the brain. Additionally, based on our behavioral characterization, we conclude that CAMK2G plays a minor role in hippocampus-dependent learning and synaptic plasticity. Rather, we show that CAMK2G is required for motor function and that the loss of CAMK2G results in impaired nest-building and marble burying behavior, which are innate behaviors that are associated with impaired neurodevelopment.
Discussion: Taken together, our results provide evidence for a unique function of this specific CAMK2 isozyme in the brain and further support the role of CAMK2G in neurodevelopment.
Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
(Copyright © 2023 Rigter, de Konink and van Woerden.)
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فهرسة مساهمة: Keywords: Camk2g knockout; behavior; isoforms; neurodevelopment; plasticity
تواريخ الأحداث: Date Created: 20230123 Latest Revision: 20230202
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC9853378
DOI: 10.3389/fnins.2022.1086994
PMID: 36685241
قاعدة البيانات: MEDLINE
الوصف
تدمد:1662-4548
DOI:10.3389/fnins.2022.1086994