دورية أكاديمية
أعرض في EDS

Glutathione S-transferases Control astrocyte activation and neuronal health during neuroinflammation.

التفاصيل البيبلوغرافية
العنوان: Glutathione S-transferases Control astrocyte activation and neuronal health during neuroinflammation.
المؤلفون: Matoba K; Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham Heersink School of Medicine, Birmingham, AL, United States., Dohi E; Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham Heersink School of Medicine, Birmingham, AL, United States.; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, United States., Choi EY; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, United States., Kano SI; Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham Heersink School of Medicine, Birmingham, AL, United States.; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, United States.
المصدر: Frontiers in molecular biosciences [Front Mol Biosci] 2023 Jan 06; Vol. 9, pp. 1080140. Date of Electronic Publication: 2023 Jan 06 (Print Publication: 2022).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Frontiers Media S.A Country of Publication: Switzerland NLM ID: 101653173 Publication Model: eCollection Cited Medium: Print ISSN: 2296-889X (Print) Linking ISSN: 2296889X NLM ISO Abbreviation: Front Mol Biosci Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Lausanne : Frontiers Media S.A., [2014]-
مستخلص: Glutathione S-transferases (GST) are phase II detoxification enzymes of xenobiotic metabolism and readily expressed in the brain. Nevertheless, the current knowledge about their roles in the brain is limited. We have recently discovered that GSTM1 promotes the production of pro-inflammatory mediators by astrocytes and enhances microglial activation during acute brain inflammation. Here we report that GSTM1 significantly affects TNF-α-dependent transcriptional program in astrocytes and modulates neuronal activities and stress during brain inflammation. We have found that a reduced expression of GSTM1 in astrocytes downregulates the expression of pro-inflammatory genes while upregulating the expression of genes involved in interferon responses and fatty acid metabolism. Our data also revealed that GSTM1 reduction in astrocytes increased neuronal stress levels, attenuating neuronal activities during LPS-induced brain inflammation. Furthermore, we found that GSTM1 expression increased in the frontal cortex and hippocampus of aging mice. Thus, this study has further advanced our understanding of the role of Glutathione S-transferases in astrocytes during brain inflammation and paved the way for future studies to determine the critical role of GSTM1 in reactive astrocyte responses in inflammation and aging.
Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
(Copyright © 2023 Matoba, Dohi, Choi and Kano.)
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معلومات مُعتمدة: P30 NS047466 United States NS NINDS NIH HHS; R01 MH113645 United States MH NIMH NIH HHS; S10 OD016374 United States OD NIH HHS
فهرسة مساهمة: Keywords: GSTM1; aging; astrocyte; glutathione S-transferase; inflammation; neuron
تواريخ الأحداث: Date Created: 20230123 Latest Revision: 20230816
رمز التحديث: 20230816
مُعرف محوري في PubMed: PMC9853189
DOI: 10.3389/fmolb.2022.1080140
PMID: 36685285
قاعدة البيانات: MEDLINE
الوصف
تدمد:2296-889X
DOI:10.3389/fmolb.2022.1080140