دورية أكاديمية

COVID-19 and liver injury: An ongoing challenge.

التفاصيل البيبلوغرافية
العنوان: COVID-19 and liver injury: An ongoing challenge.
المؤلفون: Papagiouvanni I; Fourth Department of Internal Medicine, Aristotle University of Thessaloniki, Thessaloniki 54642, Thessaloniki, Greece. ioanna.d.pap@gmail.com., Kotoulas SC; Intensive Care Unit, Hippokration General Hospital, Thessaloniki 54642, Greece., Pataka A; Department of Respiratory Medicine, G Papanikolaou Hospital, Resp Failure Unit, Aristotle University of Thessaloniki, Thessaloniki 57001, Greece., Spyratos DG; Pulmonary Department, Aristotle University of Thessaloniki, Thessaloniki 57001, Greece., Porpodis K; Pulmonary Department, Aristotle University of Thessaloniki, Thessaloniki 57001, Greece., Boutou AK; Pulmonary Department, G Papanikolaou Hospital, Resp Failure Unit, Aristotle University of Thessaloniki, Thessaloniki 54642, Greece., Papagiouvannis G; Department of Pharmacy, School of Health Sciences, Frederick University, Nicosia 1036, Cyprus., Grigoriou I; Respiratory Failure Clinic, Papanikolaou General Hospital, Thessloniki 57001, Greece., Vettas C; Fourth Department of Internal Medicine, Hippokration General Hospital, Thessaloniki 54642, Greece., Goulis I; Fourth Department of Internal Medicine, Hippokration General Hospital, Thessaloniki 54642, Greece.
المصدر: World journal of gastroenterology [World J Gastroenterol] 2023 Jan 14; Vol. 29 (2), pp. 257-271.
نوع المنشور: Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: Baishideng Publishing Group Country of Publication: United States NLM ID: 100883448 Publication Model: Print Cited Medium: Internet ISSN: 2219-2840 (Electronic) Linking ISSN: 10079327 NLM ISO Abbreviation: World J Gastroenterol Subsets: MEDLINE
أسماء مطبوعة: Publication: 2014- : Pleasanton, CA : Baishideng Publishing Group
Original Publication: Beijing : WJG Press, c1998-
مواضيع طبية MeSH: COVID-19* , Carcinoma, Hepatocellular* , Liver Neoplasms*, Humans ; SARS-CoV-2
مستخلص: The new coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was identified in December 2019, in Wuhan, China. The virus was rapidly spread worldwide, causing coronavirus disease 2019 (COVID-19) pandemic. Although COVID-19 is presented, usually, with typical respiratory symptoms ( i.e. , dyspnea, cough) and fever, extrapulmonary manifestations are also encountered. Liver injury is a common feature in patients with COVID-19 and ranges from mild and temporary elevation of liver enzymes to severe liver injury and, even, acute liver failure. The pathogenesis of liver damage is not clearly defined; multiple mechanisms contribute to liver disorder, including direct cytopathic viral effect, cytokine storm and immune-mediated hepatitis, hypoxic injury, and drug-induced liver toxicity. Patients with underlying chronic liver disease ( i.e. , cirrhosis, non-alcoholic fatty liver disease, alcohol-related liver disease, hepatocellular carcinoma, etc .) may have greater risk to develop both severe COVID-19 and further liver deterioration, and, as a consequence, certain issues should be considered during disease management. The aim of this review is to present the prevalence, clinical manifestation and pathophysiological mechanisms of liver injury in patients with SARS-CoV-2 infection. Moreover, we overview the association between chronic liver disease and SARS-CoV-2 infection and we briefly discuss the management of liver injury during COVID-19.
Competing Interests: Conflict-of-interest statement: Authors declare no conflict of interests for this article.
(©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.)
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فهرسة مساهمة: Keywords: COVID-19; Chronic liver disease; Cytokine storm; Drug-induced liver injury; Hypoxic hepatitis; Liver injury
تواريخ الأحداث: Date Created: 20230123 Date Completed: 20230124 Latest Revision: 20230201
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC9846934
DOI: 10.3748/wjg.v29.i2.257
PMID: 36687117
قاعدة البيانات: MEDLINE
الوصف
تدمد:2219-2840
DOI:10.3748/wjg.v29.i2.257