دورية أكاديمية
High MRE11 Expression Level Predicts Poor Survival in Upper Tract Urothelial Carcinomas.
| العنوان: | High MRE11 Expression Level Predicts Poor Survival in Upper Tract Urothelial Carcinomas. |
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| المؤلفون: | Jhan JH; Department of Urology.; Graduate Institute of Clinical Medicine.; Department of Urology, Kaohsiung Municipal Siaogang Hospital, Kaohsiung., Ke HL; Department of Urology.; Graduate Institute of Medicine.; Department of Urology, School of Medicine, College of Medicine, Kaohsiung Medical University., Liang PI; Graduate Institute of Clinical Medicine., Hsu WC; Graduate Institute of Medicine., Lee YC; Department of Pathology., Lin HH; Department of Urology.; Graduate Institute of Medicine., Wu YR; Department of General Medicine., Huang AM; Graduate Institute of Clinical Medicine.; Graduate Institute of Medicine.; Department of Biochemistry., Lee HY; Department of Urology.; Graduate Institute of Clinical Medicine., Yeh HC; Department of Urology.; Graduate Institute of Clinical Medicine., Wu WJ; Department of Urology.; Graduate Institute of Medicine.; Department of Urology, School of Medicine, College of Medicine, Kaohsiung Medical University., Li CC; Department of Urology.; Department of Urology, School of Medicine, College of Medicine, Kaohsiung Medical University., Li WM; Department of Urology.; Department of Urology, School of Medicine, College of Medicine, Kaohsiung Medical University.; Department of Urology, Ministry of Health and Welfare Pingtung Hospital, Pingtung, Taiwan. |
| المصدر: | Applied immunohistochemistry & molecular morphology : AIMM [Appl Immunohistochem Mol Morphol] 2023 Feb 01; Vol. 31 (2), pp. 94-100. Date of Electronic Publication: 2023 Jan 24. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 100888796 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1533-4058 (Electronic) Linking ISSN: 15334058 NLM ISO Abbreviation: Appl Immunohistochem Mol Morphol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Hagerstown, MD : Lippincott Williams & Wilkins, c1999- |
| مواضيع طبية MeSH: | Urinary Bladder Neoplasms* , Carcinoma, Transitional Cell*/pathology , Urologic Neoplasms*/diagnosis , Urologic Neoplasms*/pathology, Humans ; Retrospective Studies ; Nephroureterectomy/methods |
| مستخلص: | Upper tract urothelial carcinoma (UTUC) is an aggressive malignancy with characteristics of high metastasis and poor prognosis. There are some particularly different features of UTUC between the Asian and Western countries. Double-strand break repair protein MRE11 is a component of the MRN complex that is involved in the DNA repair pathway. Emerging studies have focused on the role of MRE11 in human malignancies with conflicting results. We aimed to establish the relationship between MRE11 expression and the oncological outcome of UTUC. This study retrospectively reviewed 150 patients who underwent radical nephroureterectomy with pathologically confirmed UTUC. Pathologic slides were reviewed, and clinical parameters were collected. An immunohistochemical study was performed, and the cytoplasmic and nuclear-staining results of UTUC were recorded. The expression of MRE11 was analyzed to identify correlations with various clinicopathological parameters, metastasis-free survival, and cancer-specific survival (CSS). MRE11 expression was significantly correlated with patients with a high pathologic stage ( P =0.001), perineural invasion ( P =0.015), and tumor necrosis ( P =0.034). Upon univariate analysis, a high MRE11 expression was associated with poor metastasis-free survival ( P =0.014, 95% CI 1.18, 4.38) and poor CSS ( P =0.001, 95% CI 2.45, 27.75). Upon multivariable analysis, a high MRE11 expression was associated with poor CSS ( P =0.019, 95% CI 1.28, 15.65). In summary, MRE11 expression could serve as a potential predictor of prognosis in patients with UTUC. Competing Interests: The authors declare no conflict of interest. (Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.) |
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| تواريخ الأحداث: | Date Created: 20230123 Date Completed: 20230222 Latest Revision: 20230922 |
| رمز التحديث: | 20230923 |
| DOI: | 10.1097/PAI.0000000000001099 |
| PMID: | 36688483 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1533-4058 |
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| DOI: | 10.1097/PAI.0000000000001099 |