دورية أكاديمية
Yeast derlin Dfm1 employs a chaperone-like function to resolve misfolded membrane protein stress.
العنوان: | Yeast derlin Dfm1 employs a chaperone-like function to resolve misfolded membrane protein stress. |
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المؤلفون: | Kandel R; Division of Biological Sciences, the Section of Cell and Developmental Biology, University of California San Diego, La Jolla, California, United States of America., Jung J; Division of Biological Sciences, the Section of Cell and Developmental Biology, University of California San Diego, La Jolla, California, United States of America., Syau D; Division of Biological Sciences, the Section of Cell and Developmental Biology, University of California San Diego, La Jolla, California, United States of America., Kuo T; Division of Biological Sciences, the Section of Cell and Developmental Biology, University of California San Diego, La Jolla, California, United States of America., Songster L; Division of Biological Sciences, the Section of Cell and Developmental Biology, University of California San Diego, La Jolla, California, United States of America., Horn C; Division of Biological Sciences, the Section of Cell and Developmental Biology, University of California San Diego, La Jolla, California, United States of America., Chapman C; Division of Biological Sciences, the Section of Cell and Developmental Biology, University of California San Diego, La Jolla, California, United States of America., Aguayo A; Division of Biological Sciences, the Section of Cell and Developmental Biology, University of California San Diego, La Jolla, California, United States of America., Duttke S; School of Molecular Biosciences, College of Veterinary Medicine, Washington State University, Pullman, Washington, United States of America., Benner C; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, California, United States of America., Neal SE; Division of Biological Sciences, the Section of Cell and Developmental Biology, University of California San Diego, La Jolla, California, United States of America. |
المصدر: | PLoS biology [PLoS Biol] 2023 Jan 23; Vol. 21 (1), pp. e3001950. Date of Electronic Publication: 2023 Jan 23 (Print Publication: 2023). |
نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. |
اللغة: | English |
بيانات الدورية: | Publisher: Public Library of Science Country of Publication: United States NLM ID: 101183755 Publication Model: eCollection Cited Medium: Internet ISSN: 1545-7885 (Electronic) Linking ISSN: 15449173 NLM ISO Abbreviation: PLoS Biol Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: San Francisco, CA : Public Library of Science, [2003]- |
مواضيع طبية MeSH: | Membrane Proteins*/metabolism , Protein Folding* , Saccharomyces cerevisiae*/metabolism , Saccharomyces cerevisiae Proteins*/metabolism, Molecular Chaperones/metabolism |
مستخلص: | Protein aggregates are a common feature of diseased and aged cells. Membrane proteins comprise a quarter of the proteome, and yet, it is not well understood how aggregation of membrane proteins is regulated and what effects these aggregates can have on cellular health. We have determined in yeast that the derlin Dfm1 has a chaperone-like activity that influences misfolded membrane protein aggregation. We establish that this function of Dfm1 does not require recruitment of the ATPase Cdc48 and it is distinct from Dfm1's previously identified function in dislocating misfolded membrane proteins from the endoplasmic reticulum (ER) to the cytosol for degradation. Additionally, we assess the cellular impacts of misfolded membrane proteins in the absence of Dfm1 and determine that misfolded membrane proteins are toxic to cells in the absence of Dfm1 and cause disruptions to proteasomal and ubiquitin homeostasis. Competing Interests: The authors have declared no competing interests exist. (Copyright: © 2023 Kandel et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.) |
References: | Cell. 2007 Jun 1;129(5):943-55. (PMID: 17540174) Mol Cell Biol. 2002 Jan;22(2):626-34. (PMID: 11756557) EMBO J. 1996 Feb 15;15(4):753-63. (PMID: 8631297) Cell. 2007 May 18;129(4):747-59. (PMID: 17512408) iScience. 2020 Aug 21;23(9):101493. (PMID: 32891886) Cell. 2011 Apr 1;145(1):79-91. (PMID: 21439629) Nature. 2001 Dec 6;414(6864):652-6. (PMID: 11740563) Cell. 2016 Jul 14;166(2):394-407. (PMID: 27321670) J Neurol Sci. 2008 Jan 15;264(1-2):77-86. (PMID: 17854834) EMBO Rep. 2013 Oct;14(10):884-90. (PMID: 23969955) Cell Rep. 2021 Sep 21;36(12):109717. (PMID: 34551305) Mol Microbiol. 2002 Mar;43(5):1295-308. (PMID: 11918814) Proc Natl Acad Sci U S A. 2005 Oct 4;102(40):14296-301. (PMID: 16186509) EMBO J. 1999 Nov 1;18(21):5994-6004. (PMID: 10545111) Mol Cell. 2005 Sep 16;19(6):741-51. (PMID: 16168370) Proc Natl Acad Sci U S A. 2001 Mar 13;98(6):3056-61. (PMID: 11248031) J Neurosci. 2009 Jun 17;29(24):7857-68. (PMID: 19535597) Mol Cell. 2020 Sep 3;79(5):768-781.e7. (PMID: 32738194) Mol Biol Cell. 1996 Dec;7(12):2029-44. (PMID: 8970163) Mol Cell. 2011 Jun 24;42(6):758-70. (PMID: 21636303) Yeast. 2000 May;16(7):651-6. (PMID: 10806427) FEBS J. 2020 Oct;287(19):4261-4283. (PMID: 32894651) Trends Biochem Sci. 2018 Sep;43(9):726-739. (PMID: 30055896) EMBO J. 1998 Nov 2;17(21):6144-54. (PMID: 9799224) J Cell Sci. 2003 Jun 1;116(Pt 11):2361-73. (PMID: 12711700) FEBS Lett. 2011 May 6;585(9):1281-6. (PMID: 21486563) Cell. 1990 Nov 16;63(4):827-34. (PMID: 1699669) STAR Protoc. 2021 Jul 07;2(3):100640. (PMID: 34278330) Bioinformatics. 2019 Nov 1;35(21):4525-4527. (PMID: 31095270) Nat Struct Mol Biol. 2011 Sep 11;18(10):1147-52. (PMID: 21909096) Mol Cell. 2009 Apr 24;34(2):212-22. (PMID: 19394298) Cell. 2018 Jun 14;173(7):1796-1809.e17. (PMID: 29779944) J Cell Biol. 2006 Jan 30;172(3):383-93. (PMID: 16449189) FEBS Lett. 1999 Apr 30;450(1-2):27-34. (PMID: 10350051) Biochem Soc Trans. 2012 Oct;40(5):1032-7. (PMID: 22988860) Cell. 1996 Nov 1;87(3):391-404. (PMID: 8898193) Sci Rep. 2015 Jun 25;5:11559. (PMID: 26109405) Yeast. 2006 Oct-Nov;23(14-15):1053-64. (PMID: 17083136) Trends Biochem Sci. 2018 Aug;43(8):593-605. (PMID: 30056836) Nat Cell Biol. 2001 Jan;3(1):24-9. (PMID: 11146622) Mol Biol Cell. 2001 May;12(5):1303-14. (PMID: 11359923) Mol Cell Biol. 2005 Jun;25(12):5242-52. (PMID: 15923638) Genes Dev. 2001 Oct 15;15(20):2660-74. (PMID: 11641273) J Biol Chem. 2009 May 29;284(22):14710-22. (PMID: 19324879) Mol Biol Cell. 2013 Jun;24(11):1765-75, S1-8. (PMID: 23536702) Nat Methods. 2012 Jun 28;9(7):676-82. (PMID: 22743772) Nat Struct Mol Biol. 2010 Jun;17(6):696-702. (PMID: 20424608) J Biol Chem. 2017 Feb 24;292(8):3112-3128. (PMID: 28077573) PLoS One. 2020 May 13;15(5):e0232755. (PMID: 32401766) Proc Natl Acad Sci U S A. 1996 Nov 26;93(24):13797-801. (PMID: 8943015) Annu Rev Cell Dev Biol. 2014;30:235-54. (PMID: 25062361) J Biol Chem. 2006 Dec 1;281(48):36856-63. (PMID: 16954204) Mol Cell. 2012 Aug 24;47(4):558-69. (PMID: 22795130) Nature. 2004 Jun 24;429(6994):841-7. (PMID: 15215856) Science. 2019 Aug 2;365(6452):. (PMID: 31249135) Science. 2020 Apr 24;368(6489):. (PMID: 32327568) Mol Cell. 2020 Jan 2;77(1):108-119.e9. (PMID: 31679820) Nature. 2021 Sep;597(7874):132-137. (PMID: 34408321) EMBO J. 2020 May 18;39(10):e102935. (PMID: 31930742) Nature. 2004 Jun 24;429(6994):834-40. (PMID: 15215855) Sci Adv. 2022 Sep 23;8(38):eabq8303. (PMID: 36149963) Cell. 2012 Jul 20;150(2):339-50. (PMID: 22817896) Open Biol. 2020 Oct;10(10):200279. (PMID: 33081638) Mol Biol Cell. 2000 Dec;11(12):4241-57. (PMID: 11102521) Mol Cell. 2018 Apr 19;70(2):242-253.e6. (PMID: 29677492) PLoS One. 2015 Jun 24;10(6):e0128206. (PMID: 26107514) Curr Opin Cell Biol. 2002 Aug;14(4):476-82. (PMID: 12383799) J Neurochem. 2005 Nov;95(3):724-31. (PMID: 16190881) Am J Physiol Renal Physiol. 2018 Mar 1;314(3):F471-F482. (PMID: 29167172) FEBS Lett. 2021 Sep;595(18):2383-2394. (PMID: 34358326) Biochim Biophys Acta Mol Cell Res. 2020 Oct;1867(10):118793. (PMID: 32645330) Mol Biol Cell. 2009 Feb;20(3):1006-19. (PMID: 19073890) Mol Cell. 2018 Mar 1;69(5):915. (PMID: 29499140) Mol Cell Biol. 1998 Jan;18(1):30-8. (PMID: 9418850) Proc Natl Acad Sci U S A. 1997 Nov 25;94(24):12944-8. (PMID: 9371780) Mol Biol Cell. 2004 Sep;15(9):4125-35. (PMID: 15215312) Cell Rep. 2021 Oct 19;37(3):109840. (PMID: 34686332) EMBO J. 2020 May 18;39(10):e102922. (PMID: 32337752) Genome Res. 2007 Nov;17(11):1634-46. (PMID: 17938163) Mol Cell. 2018 Jan 18;69(2):214-226. (PMID: 29351843) Cell Rep. 2022 Aug 9;40(6):111175. (PMID: 35947953) |
معلومات مُعتمدة: | T32 GM133351 United States GM NIGMS NIH HHS; R35 GM133565 United States GM NIGMS NIH HHS; R25 HL145817 United States HL NHLBI NIH HHS; T32 HL007444 United States HL NHLBI NIH HHS; R00 GM135515 United States GM NIGMS NIH HHS |
المشرفين على المادة: | 0 (Dfm1 protein, S cerevisiae) 0 (Membrane Proteins) 0 (Molecular Chaperones) 0 (Saccharomyces cerevisiae Proteins) |
تواريخ الأحداث: | Date Created: 20230123 Date Completed: 20230213 Latest Revision: 20240608 |
رمز التحديث: | 20240608 |
مُعرف محوري في PubMed: | PMC9894555 |
DOI: | 10.1371/journal.pbio.3001950 |
PMID: | 36689475 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1545-7885 |
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DOI: | 10.1371/journal.pbio.3001950 |