دورية أكاديمية
Risk factors for Gram-negative bacterial infection of cardiovascular implantable electronic devices: multicentre observational study (CarDINe Study).
| العنوان: | Risk factors for Gram-negative bacterial infection of cardiovascular implantable electronic devices: multicentre observational study (CarDINe Study). |
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| المؤلفون: | Pascale R; Infectious Diseases Unit, Department of Integrated Management of Infectious Risk, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy; Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy. Electronic address: renato.pascale2@unibo.it., Toschi A; Infectious Diseases Unit, Department of Integrated Management of Infectious Risk, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy., Aslan AT; Golhisar State Hospital, Department of Internal Medicine, Burdur, Turkey; Hacettepe University School of Medicine, Department of Internal Medicine, Ankara, Turkey., Massaro G; Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy; Institute of Cardiology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy., Maccaro A; Infectious Diseases Unit, Department of Integrated Management of Infectious Risk, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy., Fabbricatore D; Cardiovascular Center, Onze-Lieve-Vrouwziekenhuis Hospital, Aalst, Belgium; Department of Advanced Biomedical Sciences, Federico II University Hospital, Naples, Italy., Dell'Aquila A; Institute of Cardiology, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, ASST Spedali Civili Hospital of Brescia and University of Brescia, Brescia, Italy., Ripa M; Unit of Infectious and Tropical Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy., Işık ME; University of Health Sciences Kosuyolu Training and Research Hospital, Department of Infectious Diseases and Clinical Microbiology, Istanbul, Turkey., Kızmaz YU; University of Health Sciences Kosuyolu Training and Research Hospital, Department of Infectious Diseases and Clinical Microbiology, Istanbul, Turkey., Iacopino S; Maria Cecilia Hospital, GVM Care & Research, Cotignola, Italy., Camici M; Institute of infectious diseases, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy; HIV/AIDS Clinical Unit, National Institute for infectious Diseases L. Spallanzani IRCCS, Rome, Italy., Perna F; Cardiac Arrhythmia Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy., Akinosoglou K; Internal Medicine Department, University General Hospital of Patras, Greece., Karruli A; Department of Precision Medicine, University of Campania 'L. Vanvitelli', Monaldi Hospital, Naples, Italy., Papadimitriou-Olivgeris M; Infectious Diseases Service, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland., Kayaaslan B; Ankara Yıldırım Beyazıt University Faculty of Medicine, Ankara City Hospital, Department of Infectious Diseases and Clinical Microbiology, Ankara, Turkey., Bilir YA; Ankara Yıldırım Beyazıt University Faculty of Medicine, Ankara City Hospital, Department of Infectious Diseases and Clinical Microbiology, Ankara, Turkey., Evren Özcan E; Dokuz Eylul University, Heart Rhythm Management Center, İzmir, Turkey., Turan OE; Dokuz Eylul University, Heart Rhythm Management Center, İzmir, Turkey., Işık MC; Hacettepe University School of Medicine, Department of Infectious Diseases and Clinical Microbiology, Ankara, Turkey., Pérez-Rodríguez MT; Infectious Diseases Unit, Department of Internal Medicine, Complexo Hospitalario Universitario de Vigo, Spain Instituto de Investigación Biomédica Galicia Sur, Spain., Yagüe BL; Infectious Diseases Unit, Hospital Universitario La Paz - IDIPAZ, Madrid, Spain., Quirós AM; Emergency Department, Hospital Universitario La Paz - IDIPAZ, Madrid, Spain., Yılmaz M; Istanbul Medipol University Faculty of Medicine, Department of Infectious Diseases and Clinical Microbiology, Istanbul, Turkey., Petersdorf S; Institute of Medical Laboratory Diagnostics, HELIOS University Clinic Wuppertal, Witten/Herdecke University, Witten, Germany., De Potter T; Cardiovascular Center, Onze-Lieve-Vrouwziekenhuis Hospital, Aalst, Belgium., Durante-Mangoni E; Department of Precision Medicine, University of Campania 'L. Vanvitelli', Monaldi Hospital, Naples, Italy., Akova M; Hacettepe University School of Medicine, Department of Infectious Diseases and Clinical Microbiology, Ankara, Turkey., Curnis A; Institute of Cardiology, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, ASST Spedali Civili Hospital of Brescia and University of Brescia, Brescia, Italy., Gibertoni D; Research and Innovation Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy., Diemberger I; Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy; Institute of Cardiology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy., Scudeller L; Research and Innovation Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy., Viale P; Infectious Diseases Unit, Department of Integrated Management of Infectious Risk, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy; Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy., Giannella M; Infectious Diseases Unit, Department of Integrated Management of Infectious Risk, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy; Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy. |
| مؤلفون مشاركون: | CarDINe Study Group |
| المصدر: | International journal of antimicrobial agents [Int J Antimicrob Agents] 2023 Mar; Vol. 61 (3), pp. 106734. Date of Electronic Publication: 2023 Jan 21. |
| نوع المنشور: | Observational Study; Multicenter Study; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Science Publishers Country of Publication: Netherlands NLM ID: 9111860 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7913 (Electronic) Linking ISSN: 09248579 NLM ISO Abbreviation: Int J Antimicrob Agents Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Amsterdam : Elsevier Science Publishers, c1991- |
| مواضيع طبية MeSH: | Defibrillators, Implantable*/adverse effects , Defibrillators, Implantable*/microbiology , Cardiovascular Infections* , Gram-Negative Bacterial Infections*/epidemiology , Gram-Negative Bacterial Infections*/complications , Prosthesis-Related Infections*/epidemiology , Prosthesis-Related Infections*/diagnosis, Humans ; Fluorodeoxyglucose F18 ; Positron Emission Tomography Computed Tomography/adverse effects ; Positron Emission Tomography Computed Tomography/methods ; Retrospective Studies ; Radiopharmaceuticals ; Risk Factors ; Obesity |
| مستخلص: | Background: Infections of cardiovascular implantable electronic devices (CIED) are mainly due to Gram-positive bacteria (GPB). Data about Gram-negative bacteria CIED (GNB-CIED) infections are limited. This study aimed to investigate risk factors, clinical and diagnostic characteristics, and outcome of patients with GNB-CIED. Methods: A multicentre, international, retrospective, case-control-control study was performed on patients undergoing CIED implantation from 2015 to 2019 in 17 centres across Europe. For each patient diagnosed with GNB-CIED, one matching control with GPB-CIED infection and two matching controls without infection were selected. Results: A total of 236 patients were enrolled: 59 with GNB-CIED infection, 59 with GPB-CIED infection and 118 without infection. No between-group differences were found regarding clinical presentation, diagnostic and therapeutic management. A trend toward a higher rate of fluorodeoxyglucose positron emission computed tomography (FDG PET/CT) positivity was observed among patients with GNB than in those with GPB-CIED infection (85.7% vs. 66.7%; P = 0.208). Risk factors for GNB-CIED infection were Charlson Comorbidity Index Score (relative risk reduction, RRR = 1.211; P = 0.011), obesity (RRR = 5.122; P = 0.008), ventricular-pacing ventricular-sensing inhibited-response pacemaker implantation (RRR = 3.027; P = 0.006) and right subclavian vein site of implantation (RRR = 5.014; P = 0.004). At 180-day survival analysis, GNB-CIED infection was associated with increased mortality risk (HR = 1.842; P = 0.067). Conclusions: Obesity, high number of comorbidities and right subclavian vein implantation site were associated with increased risk of GNB-CIED infection. A prompt therapeutic intervention that may be guided using FDG PET/CT is suggested in patients with GNB-CIED infection, considering the poorer outcome observed in this group. Competing Interests: Competing Interests All the authors report no conflicts of interest. (Copyright © 2023 The Authors. Published by Elsevier Ltd.. All rights reserved.) |
| فهرسة مساهمة: | Investigator: N Caroccia, Infectious Disease Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.; F Fanì, Infectious Disease Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.; F Arbizzani, Infectious Disease Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.; R Ramanathan, Infectious Diseases Unit, Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico, 20122 Milano, Italy.; P Scarpellini, Unit of Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy.; A Marzi, Unit of Cardiac Electrophysiology, IRCCS San Raffaele Scientific Institute, Milan, Italy.; P Mazzone, Unit of Cardiac Electrophysiology, IRCCS San Raffaele Scientific Institute, Milan, Italy.; F Placentino, Maria Cecilia Hospital, GVM Care & Research, Cotignola, Italy.; G Sammarini, Maria Cecilia Hospital, GVM Care & Research, Cotignola, Italy.; E Tenti, Maria Cecilia Hospital, GVM Care & Research, Cotignola, Italy.; G Leventopulos, Department of Cardiology, Patras University Hospital Rio, Patras, Greece.; G Domenichini, Cardiology Service, University Hospital of Lausanne, Lausanne, Switzerland.; M Şahin, Istanbul Medipol University Faculty of Medicine, Department of Infectious Diseases and Clinical Microbiology, Istanbul, Turkey.; M Suárez-Varela, Infectious Diseases Unit, Department of Internal Medicine, Complexo Hospitalario Universitario de Vigo, Spain; Instituto de Investigación Biomédica Galicia Sur, Spain.; EG Villegas, Cardiac Surgery, Hospital Universitario La Paz - IDIPAZ, Madrid, Spain. Keywords: CIED infection; Cardiovascular implantable electronic devices; Endocarditis; FDG PET/CT; Gram-negative |
| المشرفين على المادة: | 0Z5B2CJX4D (Fluorodeoxyglucose F18) 0 (Radiopharmaceuticals) |
| تواريخ الأحداث: | Date Created: 20230123 Date Completed: 20230320 Latest Revision: 20230320 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1016/j.ijantimicag.2023.106734 |
| PMID: | 36690123 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1872-7913 |
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| DOI: | 10.1016/j.ijantimicag.2023.106734 |