دورية أكاديمية
أعرض في EDS

Key Factors Associated With Pulmonary Sequelae in the Follow-Up of Critically Ill COVID-19 Patients.

التفاصيل البيبلوغرافية
العنوان: Key Factors Associated With Pulmonary Sequelae in the Follow-Up of Critically Ill COVID-19 Patients.
المؤلفون: González J; Translational Research in Respiratory Medicine, University Hospital Arnau de Vilanova and Santa Maria, IRBLleida, Lleida, Spain; CIBER of Respiratory Diseases (CIBERES), Institute of Health Carlos III, Madrid, Spain., de Batlle J; Translational Research in Respiratory Medicine, University Hospital Arnau de Vilanova and Santa Maria, IRBLleida, Lleida, Spain; CIBER of Respiratory Diseases (CIBERES), Institute of Health Carlos III, Madrid, Spain., Benítez ID; Translational Research in Respiratory Medicine, University Hospital Arnau de Vilanova and Santa Maria, IRBLleida, Lleida, Spain; CIBER of Respiratory Diseases (CIBERES), Institute of Health Carlos III, Madrid, Spain., Torres G; Translational Research in Respiratory Medicine, University Hospital Arnau de Vilanova and Santa Maria, IRBLleida, Lleida, Spain; CIBER of Respiratory Diseases (CIBERES), Institute of Health Carlos III, Madrid, Spain., Santisteve S; Translational Research in Respiratory Medicine, University Hospital Arnau de Vilanova and Santa Maria, IRBLleida, Lleida, Spain., Targa ADS; Translational Research in Respiratory Medicine, University Hospital Arnau de Vilanova and Santa Maria, IRBLleida, Lleida, Spain; CIBER of Respiratory Diseases (CIBERES), Institute of Health Carlos III, Madrid, Spain., Gort-Paniello C; Translational Research in Respiratory Medicine, University Hospital Arnau de Vilanova and Santa Maria, IRBLleida, Lleida, Spain; CIBER of Respiratory Diseases (CIBERES), Institute of Health Carlos III, Madrid, Spain., Moncusí-Moix A; Translational Research in Respiratory Medicine, University Hospital Arnau de Vilanova and Santa Maria, IRBLleida, Lleida, Spain; CIBER of Respiratory Diseases (CIBERES), Institute of Health Carlos III, Madrid, Spain., Aguilà M; Translational Research in Respiratory Medicine, University Hospital Arnau de Vilanova and Santa Maria, IRBLleida, Lleida, Spain., Seck F; Translational Research in Respiratory Medicine, University Hospital Arnau de Vilanova and Santa Maria, IRBLleida, Lleida, Spain; CIBER of Respiratory Diseases (CIBERES), Institute of Health Carlos III, Madrid, Spain., Ceccato A; CIBER of Respiratory Diseases (CIBERES), Institute of Health Carlos III, Madrid, Spain; Critical Care Center, ParcTaulí Hospital Universitari, Institut d'Investigació i Innovació Parc Taulí I3PT, Sabadell, Spain., Ferrer R; Intensive Care Department, Vall d'Hebron Hospital Universitari, SODIR Research Group, Vall d'Hebron Institut de Recerca (VHIR), Barcelona, Spain., Motos A; CIBER of Respiratory Diseases (CIBERES), Institute of Health Carlos III, Madrid, Spain; Department of Pneumology, Hospital Clinic of Barcelona, August Pi i Sunyer Biomedical Research Institute - IDIBAPS, University of Barcelona, Barcelona, Spain., Riera J; Intensive Care Department, Vall d'Hebron Hospital Universitari, SODIR Research Group, Vall d'Hebron Institut de Recerca (VHIR), Barcelona, Spain., Fernández L; CIBER of Respiratory Diseases (CIBERES), Institute of Health Carlos III, Madrid, Spain; Department of Pneumology, Hospital Clinic of Barcelona, August Pi i Sunyer Biomedical Research Institute - IDIBAPS, University of Barcelona, Barcelona, Spain., Menéndez R; CIBER of Respiratory Diseases (CIBERES), Institute of Health Carlos III, Madrid, Spain; Pulmonology Service, University and Polytechnic Hospital La Fe, Valencia, Spain., Lorente JÁ; CIBER of Respiratory Diseases (CIBERES), Institute of Health Carlos III, Madrid, Spain; Hospital Universitario de Getafe, Madrid, Spain., Peñuelas O; CIBER of Respiratory Diseases (CIBERES), Institute of Health Carlos III, Madrid, Spain; Hospital Universitario de Getafe, Madrid, Spain., Garcia-Gasulla D; Barcelona Supercomputing Center (BSC), Barcelona, Spain., Peñasco Y; Servicio de Medicina Intensiva, Hospital Universitario Marqués de Valdecilla, Santander, Spain., Ricart P; Servei de Medicina Intensiva, Hospital Universitari Germans Trias, Badalona, Spain., Abril Palomares E; Hospital Universitario Torrejón, Madrid, Spain., Aguilera L; Servicio de Anestesiología y Reanimación, Hospital Universitario Basurto, Bilbao, Spain., Rodríguez A; Critical Care Department, Hospital Joan XXIII, Tarragona, Spain., Boado Varela MV; Servicio de Medicina Intensiva, Hospital de Cruces, Baracaldo, Vizcaya, Spain., Beteré B; Servicio de Análisis Clínicos, Hospital Universitario Príncipe de Asturias, Alcalá de Henares, Spain., Pozo-Laderas JC; UGC-Medicina Intensiva, Hospital Universitario Reina Sofia, Instituto Maimonides IMIBIC, Córdoba, Spain., Solé-Violan J; Critical Care Department, Hospital Dr. Negrín Gran Canaria, Universidad Fernando Pessoa, Las Palmas, Gran Canaria, Canarias, Spain., Salvador-Adell I; Hospital Verge de la Cinta, Tortosa, Tarragona, Spain., Novo MA; Servei de Medicina Intensiva, Hospital Universitari Son Espases, Palma de Mallorca, Illes Balears, Spain., Barberán J; Hospital Universitario HM Montepríncipe, Universidad San Pablo-CEU, Madrid, Spain., Amaya Villar R; Intensive Care Clinical Unit, Hospital Universitario Virgen de Rocío, Sevilla, Spain., Garnacho-Montero J; Intensive Care Clinical Unit, Hospital Universitario Virgen Macarena, Sevilla, Spain., Gómez JM; Hospital General Universitario Gregorio Marañón, Madrid, Spain., Blandino Ortiz A; Servicio de Medicina Intensiva, Hospital Universitario Ramón y Cajal, Madrid, Spain., Tamayo Lomas L; Critical Care Department, Hospital Universitario Río Hortega de Valladolid, Valladolid, Spain., Úbeda A; Servicio de Medicina Intensiva, Hospital Punta de Europa, Algeciras, Spain., Catalán-González M; Department of Intensive Care Medicine, Hospital Universitario 12 de Octubre, Madrid, Spain., Sánchez-Miralles A; Hospital de Sant Joan d'Alacant, Alacant, Spain., Martínez Varela I; Critical Care Department, Hospital Universitario Lucus Augusti, Lugo, Spain., Jorge García RN; Intensive Care Department, Hospital Nuestra Señora de Gracia, Zaragoza, Spain., Franco N; Hospital Universitario de Móstoles, Madrid, Spain., Gumucio-Sanguino VD; Department of Intensive Care, Hospital Universitari de Bellvitge, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain., Bustamante-Munguira E; Department of Intensive Care Medicine, Hospital Clínico Universitario Valladolid, Valladolid, Spain., Valdivia LJ; Hospital Universitario de León, León, Spain., Caballero J; Critical Care Department, Hospital Universitari Arnau de Vilanova, IRBLleida, Lleida, Spain., Gallego E; Unidad de Cuidados Intensivos, Hospital Universitario San Pedro de Alcántara, Cáceres, Spain., Rodríguez C; Hospital Universitario Infanta Leonor, Madrid, Spain., Castellanos-Ortega Á; Servicio de Medicina Intensiva, Hospital Universitario y Politécnico La Fe, Valencia, Spain., Trenado J; Servicio de Medicina Intensiva, Hospital Universitario Mútua de Terrassa, Terrassa, Barcelona, Spain., Marin-Corral J; Critical Care Department, Hospital del Mar-IMIM, Barcelona, Spain., Albaiceta GM; CIBER of Respiratory Diseases (CIBERES), Institute of Health Carlos III, Madrid, Spain; Departamento de Biología Funcional, Instituto Universitario de Oncología del Principado de Asturias, Universidad de Oviedo, Instituto de Investigación Sanitaria del Principado de Asturias, Hospital Central de Asturias, Oviedo, Spain., de la Torre MDC; Hospital de Mataró de Barcelona, Spain., Loza-Vázquez A; Unidad de Medicina Intensiva, Hospital Universitario Virgen de Valme, Sevilla, Spain., Vidal P; Complexo Hospitalario Universitario de Ourense, Ourense, Spain., Añón JM; CIBER of Respiratory Diseases (CIBERES), Institute of Health Carlos III, Madrid, Spain; Servicio de Medicina Intensiva, Hospital Universitario La Paz, IdiPAZ, Madrid, Spain., Carbajales Pérez C; Intensive Care Unit, Hospital Álvaro Cunqueiro, Vigo, Spain., Sagredo V; Hospital Universitario de Salamanca, Salamanca, Spain., Carbonell N; Intensive Care Unit, Hospital Clínico y Universitario de Valencia, Valencia, Spain., Socias L; Intensive Care Unit, Hospital Son Llàtzer, Palma de Mallorca, Illes Balears, Spain., Barberà C; Hospital Santa Maria, IRBLleida, Lleida, Spain., Estella A; Intensive Care Unit, University Hospital of Jerez, Medicine Department University of Cadiz, INiBICA, Spain., Diaz E; Department of Medicine, Universitat Autònoma de Barcelona (UAB), Critical Care Department, Corporació Sanitària Parc Taulí, Sabadell, Barcelona, Spain., de Gonzalo-Calvo D; Translational Research in Respiratory Medicine, University Hospital Arnau de Vilanova and Santa Maria, IRBLleida, Lleida, Spain; CIBER of Respiratory Diseases (CIBERES), Institute of Health Carlos III, Madrid, Spain., Torres A; CIBER of Respiratory Diseases (CIBERES), Institute of Health Carlos III, Madrid, Spain; Department of Pneumology, Hospital Clinic of Barcelona, August Pi i Sunyer Biomedical Research Institute - IDIBAPS, University of Barcelona, Barcelona, Spain., Barbé F; Translational Research in Respiratory Medicine, University Hospital Arnau de Vilanova and Santa Maria, IRBLleida, Lleida, Spain; CIBER of Respiratory Diseases (CIBERES), Institute of Health Carlos III, Madrid, Spain. Electronic address: febarbe.lleida.ics@gencat.cat.
مؤلفون مشاركون: CIBERESUCICOVID Project
المصدر: Archivos de bronconeumologia [Arch Bronconeumol] 2023 Apr; Vol. 59 (4), pp. 205-215. Date of Electronic Publication: 2023 Jan 07.
نوع المنشور: Observational Study; Multicenter Study; Journal Article
اللغة: English; Spanish; Castilian
بيانات الدورية: Publisher: Elsevier España Country of Publication: Spain NLM ID: 0354720 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1579-2129 (Electronic) Linking ISSN: 03002896 NLM ISO Abbreviation: Arch Bronconeumol Subsets: MEDLINE
أسماء مطبوعة: Publication: Madrid: Elsevier España
Original Publication: Madrid : Sociedad Española de Patología Respiratoria [1964]-
مواضيع طبية MeSH: COVID-19*/complications , Pulmonary Emphysema*, Humans ; Female ; Middle Aged ; Male ; Critical Illness ; Follow-Up Studies ; Disease Progression ; Lung/diagnostic imaging
مستخلص: Introduction: Critical COVID-19 survivors have a high risk of respiratory sequelae. Therefore, we aimed to identify key factors associated with altered lung function and CT scan abnormalities at a follow-up visit in a cohort of critical COVID-19 survivors.
Methods: Multicenter ambispective observational study in 52 Spanish intensive care units. Up to 1327 PCR-confirmed critical COVID-19 patients had sociodemographic, anthropometric, comorbidity and lifestyle characteristics collected at hospital admission; clinical and biological parameters throughout hospital stay; and, lung function and CT scan at a follow-up visit.
Results: The median [p 25 -p 75 ] time from discharge to follow-up was 3.57 [2.77-4.92] months. Median age was 60 [53-67] years, 27.8% women. The mean (SD) percentage of predicted diffusing lung capacity for carbon monoxide (D LCO ) at follow-up was 72.02 (18.33)% predicted, with 66% of patients having D LCO <80% and 24% having D LCO <60%. CT scan showed persistent pulmonary infiltrates, fibrotic lesions, and emphysema in 33%, 25% and 6% of patients, respectively. Key variables associated with D LCO <60% were chronic lung disease (CLD) (OR: 1.86 (1.18-2.92)), duration of invasive mechanical ventilation (IMV) (OR: 1.56 (1.37-1.77)), age (OR [per-1-SD] (95%CI): 1.39 (1.18-1.63)), urea (OR: 1.16 (0.97-1.39)) and estimated glomerular filtration rate at ICU admission (OR: 0.88 (0.73-1.06)). Bacterial pneumonia (1.62 (1.11-2.35)) and duration of ventilation (NIMV (1.23 (1.06-1.42), IMV (1.21 (1.01-1.45)) and prone positioning (1.17 (0.98-1.39)) were associated with fibrotic lesions.
Conclusion: Age and CLD, reflecting patients' baseline vulnerability, and markers of COVID-19 severity, such as duration of IMV and renal failure, were key factors associated with impaired D LCO and CT abnormalities.
(Published by Elsevier España, S.L.U.)
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فهرسة مساهمة: Investigator: MA Cabello; V Alcaraz-Serrano; C Aldecoa; C Alegre; ÁA Calderón; S Álvarez; AÁ Ruiz; R Andrea; MA Aparicio; M Arrieta; JI Ayestarán; JR Badia; M Badía; OB Pravia; AB Mariño; B Balsera; L Barbena; E Barbeta; T Bardi; PB Segade; M Barroso; JÁB García; J Bermejo; J Bigas; R Blancas; MLB Cortés; MB Saera; N Bofill; MTB Vieiro; L Bueno; J Bustamante-Munguira; CDB Martínez; DC Hermoso; SC Fernández; I Cano; J Canseco; PC Fernández; LC García; S Carvalho; M Castellà; A Castellví; P Castro; MJ Centelles-Serrano; RC Ávila; C Cillóniz; L Clar; C Climent; J Codina; P Conde; S Contreras; RF Parra; RP Sánchez; D Mendoza; Y Díaz; MDR Vilas; CD Moreno; I Dot; PE Giraudo; IE Arijón; TF Monjo; J Fernández; C Ferrando; A Figueras; LF Espina; E Franquesa; À Furro; A Gabarrus; C Galbán; F García; B García; EG Prieto; CG Redruello; AG Sagastume; MLG Castillo; G Gomà; VG Casal; S Gómez; CG Gonzalez; F Gordo; MP Gracia; MJG Fernández; A Herraiz; R Herrán-Monge; M Ibarz; S Iglesias; MT Janer; G Jiménez; MJ Díaz; K Kiarostami; JIL Álvarez; M León; A López-Gavín; DM Guerrero; NM Herrera; RM Mendiluce; CL Mantellini; GM Naya; IM Barcos; P Marcos; EM Peis; MM Cuadrado; MCM Delgado; PM Vicente; M Martínez; CEM Fernández; MDM Juan; BM Palacios; JFM Jimenez; JR Masclans; E Maseda; EMM Fernández; PM Banderas; O Minguez; M Miralbés; J Monclou; JC Montejo-González; N Montserrat; MM Aznar; D Morales; SGM Cano; DM Rodríguez; R Muñoz-Bermúdez; JM Nicolás; RN Bou; RN Salinas; M Ocón; A Ortega; S Ossa; P Pagliarani; F Parrilla; J Pedregosa-Díaz; LP Bastida; P Pérez; F Pérez-García; GP Planelles; EP Rubio; DP Laguna; J Prados; A Pujol; NR Coll; GR Sanchez-Giron; F Roche-Campo; L Rodriguez; FR Castro; S Rodríguez; CR Ruiz; J Rubio; AR López; ÁL Ruiz-García; MR Miralles; PR Murúa; ES Paz; AS Degracia; M Sanchez; A Sánchez; SS Chinesta; B Santacoloma; M Sanchez; MT Sariñena; MS Pensado; L Serra; M Serra-Fortuny; AS Lázaro; L Servià; L Soliva; C Speziale; A Tormos; M Torres; C Tranque-Liberal; S Trefler; J Trujillano; R Vaca; E Val; LV Ruiz; M Vallverdú; MVH Martin-Montalvo; SV Adrio; N Vázquez; J Vengoechea; C Vilà-Vilardel; J Vilanova; TV Warrington; H Yang; M Yang; A Zapatero
Keywords: COVID-19; CT abnormalities; ICU; Lung function; Sequelae
تواريخ الأحداث: Date Created: 20230123 Date Completed: 20230405 Latest Revision: 20230424
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC9824938
DOI: 10.1016/j.arbres.2022.12.017
PMID: 36690515
قاعدة البيانات: MEDLINE
الوصف
تدمد:1579-2129
DOI:10.1016/j.arbres.2022.12.017