دورية أكاديمية
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Neuromapping olfactory stimulation using magnetoencephalography - visualizing smell, a proof-of-concept study.

التفاصيل البيبلوغرافية
العنوان: Neuromapping olfactory stimulation using magnetoencephalography - visualizing smell, a proof-of-concept study.
المؤلفون: Tarfa R; University of Pittsburgh School of Medicine, Pittsburgh, PA, United States.; Department of Otolaryngology - Head and Neck Surgery, University of Pittsburgh Medical Center (UPMC), Pittsburgh, PA, United States., Yu SE; Department of Otolaryngology - Head & Neck Surgery, Harvard Medical School, Boston, MA, United States., Ahmed OH; Penn Medicine Becker ENT & Allergy, Robbinsville, NJ, United States., Moore JA; Department of Otolaryngology - Head and Neck Surgery, University of Pittsburgh Medical Center (UPMC), Pittsburgh, PA, United States., Bruña R; Department of Radiology, Universidad Complutense de Madrid (UCM), IdISSC, Madrid, Spain., Velasquez N; Department of Otolaryngology, Cleveland Clinic Florida, Weston, FL, United States., Poplawsky AJ; Center for Neuroscience, McGowan Institute of Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA, United States., Coffman BA; Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, United States., Lee SE; Division of Otolaryngology - Head & Neck Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.
المصدر: Frontiers in allergy [Front Allergy] 2023 Jan 09; Vol. 3, pp. 1019265. Date of Electronic Publication: 2023 Jan 09 (Print Publication: 2022).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Frontiers Media S.A Country of Publication: Switzerland NLM ID: 9918227355906676 Publication Model: eCollection Cited Medium: Internet ISSN: 2673-6101 (Electronic) Linking ISSN: 26736101 NLM ISO Abbreviation: Front Allergy Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Lausanne, Switzerland : Frontiers Media S.A., [2020]-
مستخلص: Importance: Currently, clinical assessment of olfaction is largely reliant on subjective methods that require patient participation. The objective method for measuring olfaction, using electroencephalogram (EEG) readings, can be supplemented with the improved temporal resolution of magnetoencephalography (MEG) for olfactory measurement that can delineate cortical and peripheral olfactory loss. MEG provides high temporal and spatial resolution which can enhance our understanding of central olfactory processing compared to using EEG alone.
Objective: To determine the feasibility of building an in-house portable olfactory stimulator paired with electrophysiological neuroimaging technique with MEG to assess olfaction in the clinical setting.
Design Setting and Participants: This proof-of-concept study utilized a paired MEG-olfactometer paradigm to assess olfaction in three normosmic participants. We used a two-channel olfactory stimulator to deliver odorants according to a programmed stimulus-rest paradigm. Two synthetic odorants: 2% phenethyl alcohol (rose) and 0.5% amyl acetate (banana) were delivered in increasing increments of time followed by periods of rest. Cortical activity was measured via a 306-channel MEG system.
Main Outcomes and Measures: Primary outcome measure was the relative spectral power for each frequency band, which was contrasted between rest and olfactory stimulation.
Results: Compared to rest, olfactory stimulation produced a 40% increase in relative alpha power within the olfactory cortex bilaterally with both odorants. A 25%-30% increase in relative alpha power occurred in the left orbitofrontal cortex and precentral gyrus with phenethyl alcohol stimulation but not amyl acetate.
Conclusion and Relevance: In this proof-of-concept study, we demonstrate the feasibility of olfactory measurement via an olfactometer-MEG paradigm. We found that odorant-specific cortical signatures can be identified using this paradigm, setting the basis for further investigation of this system as a prognostic tool for olfactory loss.
Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
(© 2023 Tarfa, Yu, Ahmed, Moore, Bruña, Velasquez, Poplawsky, Coffman and Lee.)
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فهرسة مساهمة: Keywords: device; electroencephalography (EEG); magnetoencephalagraphy (MEG); neurological; olfaction
تواريخ الأحداث: Date Created: 20230126 Latest Revision: 20230202
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC9869273
DOI: 10.3389/falgy.2022.1019265
PMID: 36698377
قاعدة البيانات: MEDLINE
الوصف
تدمد:2673-6101
DOI:10.3389/falgy.2022.1019265