دورية أكاديمية
Comparison of ultrasonography and pathology features between children and adolescents with papillary thyroid carcinoma.
العنوان: | Comparison of ultrasonography and pathology features between children and adolescents with papillary thyroid carcinoma. |
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المؤلفون: | Jie Y; Department of Ultrasound, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital Sun Yat-Sen University, Guangzhou, China., Ruan J; Department of Ultrasound, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital Sun Yat-Sen University, Guangzhou, China., Cai Y; Department of Ultrasound, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital Sun Yat-Sen University, Guangzhou, China., Luo M; Department of Ultrasound, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital Sun Yat-Sen University, Guangzhou, China., Liu R; Department of Ultrasound, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital Sun Yat-Sen University, Guangzhou, China. |
المصدر: | Heliyon [Heliyon] 2023 Jan 12; Vol. 9 (1), pp. e12828. Date of Electronic Publication: 2023 Jan 12 (Print Publication: 2023). |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Elsevier Ltd Country of Publication: England NLM ID: 101672560 Publication Model: eCollection Cited Medium: Print ISSN: 2405-8440 (Print) Linking ISSN: 24058440 NLM ISO Abbreviation: Heliyon Subsets: PubMed not MEDLINE |
أسماء مطبوعة: | Original Publication: London : Elsevier Ltd, [2015]- |
مستخلص: | Objective: To compare the ultrasonography and pathology features between children and adolescents with papillary thyroid carcinoma (PTC). Methods: A total of 53 patients who were surgically diagnosed with childhood or adolescent PTC between 2017 and 2022 were included in this study. The pre-operative ultrasonography, post-operative histology, and molecular and clinical characteristics were retrospectively analyzed. Results: No differences were observed in composition, echogenicity, and shape using ultrasonography. Moreover, there was a significantly higher rate of extrathyroidal extension, punctate echogenic foci, and lymph node metastases in children compared to adolescents. The molecular analysis showed that BRAF V600E mutations are the most prevalent abnormality in adolescent PTC (12/20, 60.0%). However, they are less in childhood PTC (7/23, 30.4%). In addition, using next-generation sequencing, three cases with oncogenic fusion (one TRIM33-RET case, one CCDC6-RET case, and one STRN-ALK case) were identified in childhood PTC. Conclusion: The frequency of extrathyroidal extension, punctate echogenic foci, and lymph node metastases were higher in childhood PTC, while BRAF V600E mutations were higher in adolescent PTC. (© 2023 The Authors.) |
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فهرسة مساهمة: | Keywords: ACR, American College of Radiology; AJCC, American Joint Committee on Cancer; ATA, American thyroid association; Adolescents; CCDC6, Coiled-coil domain containing 6; Childhood; FNAC, Fine needle aspiration cytology; Molecular characteristics; NGS, Next-generation sequencing; PTC, Papillary thyroid cancer; Papillary thyroid carcinoma; RET, Ret proto-oncogene; TI-RADS, Thyroid imaging reporting and data system; TRIM33, Tripartite motif-containing 33; Ultrasonography |
تواريخ الأحداث: | Date Created: 20230127 Latest Revision: 20230202 |
رمز التحديث: | 20240628 |
مُعرف محوري في PubMed: | PMC9871215 |
DOI: | 10.1016/j.heliyon.2023.e12828 |
PMID: | 36704282 |
قاعدة البيانات: | MEDLINE |
تدمد: | 2405-8440 |
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DOI: | 10.1016/j.heliyon.2023.e12828 |