دورية أكاديمية
The Enigmas of Lymphatic Muscle Cells: Where Do They Come From, How Are They Maintained, and Can They Regenerate?
| العنوان: | The Enigmas of Lymphatic Muscle Cells: Where Do They Come From, How Are They Maintained, and Can They Regenerate? |
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| المؤلفون: | Kenney HM; Center for Musculoskeletal Research, University of Rochester Medical Center, 601 Elmwood Ave, Box 665, Rochester, NY, 14642, USA.; Department of Pathology & Laboratory Medicine, University of Rochester Medical Center, Rochester, NY, USA., Peng Y; Center for Musculoskeletal Research, University of Rochester Medical Center, 601 Elmwood Ave, Box 665, Rochester, NY, 14642, USA.; Department of Pathology & Laboratory Medicine, University of Rochester Medical Center, Rochester, NY, USA., de Mesy Bentley KL; Center for Musculoskeletal Research, University of Rochester Medical Center, 601 Elmwood Ave, Box 665, Rochester, NY, 14642, USA.; Department of Pathology & Laboratory Medicine, University of Rochester Medical Center, Rochester, NY, USA.; Department of Orthopaedics, University of Rochester Medical Center, Rochester, NY, USA., Xing L; Center for Musculoskeletal Research, University of Rochester Medical Center, 601 Elmwood Ave, Box 665, Rochester, NY, 14642, USA.; Department of Pathology & Laboratory Medicine, University of Rochester Medical Center, Rochester, NY, USA., Ritchlin CT; Center for Musculoskeletal Research, University of Rochester Medical Center, 601 Elmwood Ave, Box 665, Rochester, NY, 14642, USA.; Department of Medicine, Division of Allergy, Immunology, Rheumatology, University of Rochester Medical Center, Rochester, NY, USA., Schwarz EM; Center for Musculoskeletal Research, University of Rochester Medical Center, 601 Elmwood Ave, Box 665, Rochester, NY, 14642, USA.; Department of Pathology & Laboratory Medicine, University of Rochester Medical Center, Rochester, NY, USA.; Department of Orthopaedics, University of Rochester Medical Center, Rochester, NY, USA.; Department of Medicine, Division of Allergy, Immunology, Rheumatology, University of Rochester Medical Center, Rochester, NY, USA. |
| المصدر: | Current rheumatology reviews [Curr Rheumatol Rev] 2023 Jun 05; Vol. 19 (3), pp. 246-259. |
| نوع المنشور: | Review; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Bentham Science Publishers Country of Publication: United Arab Emirates NLM ID: 101261938 Publication Model: Print Cited Medium: Internet ISSN: 1875-6360 (Electronic) Linking ISSN: 15733971 NLM ISO Abbreviation: Curr Rheumatol Rev Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Saif Zone, Sharjah, U.A.E. ; San Francisco, CA : Bentham Science Publishers, 2005- |
| مواضيع طبية MeSH: | Lymphatic Vessels*/metabolism , Lymphatic Vessels*/pathology , Arthritis, Rheumatoid*, Humans ; Muscle Cells ; Regeneration |
| مستخلص: | Lymphatic muscle cell (LMC) contractility and coverage of collecting lymphatic vessels (CLVs) are integral to effective lymphatic drainage and tissue homeostasis. In fact, defects in lymphatic contractility have been identified in various conditions, including rheumatoid arthritis, inflammatory bowel disease, and obesity. However, the fundamental role of LMCs in these pathologic processes is limited, primarily due to the difficulty in directly investigating the enigmatic nature of this poorly characterized cell type. LMCs are a unique cell type that exhibit dual tonic and phasic contractility with hybrid structural features of both vascular smooth muscle cells (VSMCs) and cardiac myocytes. While advances have been made in recent years to better understand the biochemistry and function of LMCs, central questions regarding their origins, investiture into CLVs, and homeostasis remain unanswered. To summarize these discoveries, unexplained experimental results, and critical future directions, here we provide a focused review of current knowledge and open questions related to LMC progenitor cells, recruitment, maintenance, and regeneration. We also highlight the high-priority research goal of identifying LMC-specific genes towards genetic conditional- inducible in vivo gain and loss of function studies. While our interest in LMCs has been focused on understanding lymphatic dysfunction in an arthritic flare, these concepts are integral to the broader field of lymphatic biology, and have important potential for clinical translation through targeted therapeutics to control lymphatic contractility and drainage. (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.) |
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| معلومات مُعتمدة: | R01AG059775,R01AG059775,R01AG059775 United States AG NIA NIH HHS; R01AR056702,R01AR069000,T32AR076950,P30AR069655,R01AR056702,R01AR069000,P30AR069655,T32AR076950,R01AR056702,R01AR069000,T32AR076950,P30AR069655 United States AR NIAMS NIH HHS; P30 AR069655 United States AR NIAMS NIH HHS; R01 AR069000 United States AR NIAMS NIH HHS; T32 GM007356 United States GM NIGMS NIH HHS; R01 AG059775 United States AG NIA NIH HHS; T32GM007356,T32GM007356,T32GM007356,T32GM007356 United States GM NIGMS NIH HHS; T32 AR076950 United States AR NIAMS NIH HHS; R01 AR056702 United States AR NIAMS NIH HHS; F30 AG076326 United States AG NIA NIH HHS |
| فهرسة مساهمة: | Keywords: Lymphatic muscle cell; cell recruitment; contractility; development; lymphangiogenesis.; regeneration; smooth muscle; striated muscle |
| تواريخ الأحداث: | Date Created: 20230127 Date Completed: 20230608 Latest Revision: 20240606 |
| رمز التحديث: | 20240606 |
| مُعرف محوري في PubMed: | PMC10257750 |
| DOI: | 10.2174/1573397119666230127144711 |
| PMID: | 36705238 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1875-6360 |
|---|---|
| DOI: | 10.2174/1573397119666230127144711 |