دورية أكاديمية
Characterization of thymol derivatives from Eupatorium fortunei Turcz. aerial parts.
| العنوان: | Characterization of thymol derivatives from Eupatorium fortunei Turcz. aerial parts. |
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| المؤلفون: | Nguyen-Ngoc H; Faculty of Pharmacy, PHENIKAA University, Hanoi, Vietnam., Trang BTT; Faculty of Chemical Technology, Hanoi University of Industry, Hanoi, Vietnam., Thu DTH; Center for High Technology Development, Vietnam Academy of Science and Technology (VAST), Hanoi, Vietnam., Nguyen HT; Faculty of Pharmacy, PHENIKAA University, Hanoi, Vietnam., Hoang VD; School of Chemical Engineering, Hanoi University of Science and Technology, Hanoi, Vietnam., Tran Q; Department of Chemistry, College of Natural Sciences, Can Tho University, Can Tho, Vietnam., Nguyen TN; Institute of Biotechnology and Food Technology, Industrial University of Ho Chi Minh City, Ho Chi Minh, Vietnam., Quang DN; Faculty of Chemistry, Hanoi National University of Education, Hanoi, Vietnam., Pham GN; Université Côte d'Azur, Nice Institute of Chemistry, Nice, France., Le Dang Q; Institute for Tropical Technology, VAST, Hanoi, Vietnam.; Graduate University of Science and Technology, VAST, Hanoi, Vietnam. |
| المصدر: | Natural product research [Nat Prod Res] 2024 Jul; Vol. 38 (13), pp. 2306-2312. Date of Electronic Publication: 2023 Jan 28. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Taylor & Francis Health Sciences Country of Publication: England NLM ID: 101167924 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1478-6427 (Electronic) Linking ISSN: 14786419 NLM ISO Abbreviation: Nat Prod Res Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Milton Park, UK : Taylor & Francis Health Sciences, c2003- |
| مواضيع طبية MeSH: | Thymol*/chemistry , Thymol*/pharmacology , Thymol*/analogs & derivatives , Eupatorium*/chemistry , Plant Components, Aerial*/chemistry , Cholinesterase Inhibitors*/chemistry , Cholinesterase Inhibitors*/pharmacology , Cholinesterase Inhibitors*/isolation & purification, Molecular Structure ; Magnetic Resonance Spectroscopy ; Glycoside Hydrolase Inhibitors/chemistry ; Glycoside Hydrolase Inhibitors/pharmacology ; Glycoside Hydrolase Inhibitors/isolation & purification ; Acetylcholinesterase/metabolism ; Circular Dichroism |
| مستخلص: | From the aerial parts of Eupatorium fortunei , four thymol derivatives ( 1 - 4 ) were isolated and structurally elucidated by NMR and mass spectroscopic methods. Of which, a new dimeric thymol derivative ( 1 ) was characterized and its absolute configuration was established by electronic circular dichroism quantum method. In addition, the 1D and 2D NMR as well as HR-ESI mass spectral data of 2 were provided for the first time. Compounds 2 - 4 were evaluated for their inhibitory activity against α-glucosidase and acetylcholinesterase enzymes. All tested compounds showed weak inhibition at the concentration range of 1-256 μg/mL in both enzymatic assays. |
| فهرسة مساهمة: | Keywords: Eupatorium fortunei; acetylcholinesterase; thymol derivatives; α-glucosidase |
| المشرفين على المادة: | 3J50XA376E (Thymol) 0 (Cholinesterase Inhibitors) 0 (Glycoside Hydrolase Inhibitors) EC 3.1.1.7 (Acetylcholinesterase) |
| تواريخ الأحداث: | Date Created: 20230128 Date Completed: 20240711 Latest Revision: 20240711 |
| رمز التحديث: | 20240711 |
| DOI: | 10.1080/14786419.2023.2172726 |
| PMID: | 36708256 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1478-6427 |
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| DOI: | 10.1080/14786419.2023.2172726 |