دورية أكاديمية
An inquiry into the treatment of sepsis using plasma exchange therapy: A systematic review and meta-analysis.
| العنوان: | An inquiry into the treatment of sepsis using plasma exchange therapy: A systematic review and meta-analysis. |
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| المؤلفون: | Zhang L; Department of Critical Care, Beijing Lu He hospital, Capital Medical University, Beijing, People's Republic of China., Zhao XY; Department of Critical Care, Beijing Lu He hospital, Capital Medical University, Beijing, People's Republic of China., Guo SY; Department of Critical Care, Beijing Lu He hospital, Capital Medical University, Beijing, People's Republic of China., Jiang J; Department of Critical Care, Beijing Lu He hospital, Capital Medical University, Beijing, People's Republic of China., Wang G; Department of Critical Care, Beijing Lu He hospital, Capital Medical University, Beijing, People's Republic of China., Weng YB; Department of Critical Care, Beijing Lu He hospital, Capital Medical University, Beijing, People's Republic of China. |
| المصدر: | International wound journal [Int Wound J] 2023 Aug; Vol. 20 (6), pp. 1979-1986. Date of Electronic Publication: 2023 Jan 30. |
| نوع المنشور: | Meta-Analysis; Systematic Review; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Blackwell Pub Country of Publication: England NLM ID: 101230907 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1742-481X (Electronic) Linking ISSN: 17424801 NLM ISO Abbreviation: Int Wound J Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Oxford : Blackwell Pub., c2004- |
| مواضيع طبية MeSH: | Plasma Exchange* , Sepsis*/therapy, Humans ; Treatment Outcome ; Controlled Clinical Trials as Topic |
| مستخلص: | Sepsis is a potentially lethal condition that occurs when the body's response to infection damages tissue and organs. The production of inflammatory mediators typically assists in defending the body against infection; however, an overreaction to inflammation can cause coagulation problems, vascular endothelial damage, and organ hypoperfusion. Blood purification methods, such as plasmapheresis, can effectively remove inflammatory mediators from plasma. The purpose of this meta-analysis was to explore the efficacy of plasma exchange for sepsis treatment as noted in recent studies. The authors searched the Pubmed (Medline), Cochrane Central Register of Controlled Trials (The Cochrane Library), Embase (Ovid), and Scopus databases and included controlled clinical studies that compared plasmapheresis or plasma filtration with conventional treatment in patients with severe sepsis. The Newcastle-Ottawa Scale literature quality assessment tool was used to assess the risk of bias. The primary study outcome was all-cause mortality. The random effects model was adopted for conducting the meta-analysis. Among the 1013 records found, the study included 5 trials, all of which carried a low risk of bias. The use of plasmapheresis was associated with a longer stay in the intensive care unit (odds ratio [OR], 0.85, 95% confidence interval [CI], 0.39-1.32, heterogeneity [I 2 ] = 0%), a significant reduction in all-cause mortality (OR, 0.54, 95% CI, 0.33-0.89, I 2 = 70%), and reduced mortality (OR, 0.29, 95% CI, 0.13-0.67, I 2 = 0%) in adults; the results for children differed from this (OR, 0.79, 95% CI, 0.36-1.72, I 2 = 89%). Four trials reported no adverse events; one trial reported an adverse event related to plasma exchange, including an instance of hypotension in one patient. Plasmapheresis appeared to be an effective treatment for patients suffering from sepsis. A large number of additional randomised controlled trials are needed to confirm this finding. (© 2023 The Authors. International Wound Journal published by Medicalhelplines.com Inc and John Wiley & Sons Ltd.) |
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| فهرسة مساهمة: | Keywords: multiple organ failure; plasma exchange; sepsis; vasoactive drugs |
| تواريخ الأحداث: | Date Created: 20230131 Date Completed: 20231117 Latest Revision: 20231117 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC10332988 |
| DOI: | 10.1111/iwj.14059 |
| PMID: | 36717980 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1742-481X |
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| DOI: | 10.1111/iwj.14059 |