دورية أكاديمية
Brain damage serum biomarkers induced by COVID-19 in patients from northeast Brazil.
| العنوان: | Brain damage serum biomarkers induced by COVID-19 in patients from northeast Brazil. |
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| المؤلفون: | Silva RC; Laboratory of Immunomodulation and New Therapeutic Approaches (LINAT), Research Center in Immunomodulation and New Therapeutic Approaches Suely Galdino (Nupit SG), Federal University of Pernambuco (UFPE), Recife, PE, Brazil., da Rosa MM; Laboratory of Immunomodulation and New Therapeutic Approaches (LINAT), Research Center in Immunomodulation and New Therapeutic Approaches Suely Galdino (Nupit SG), Federal University of Pernambuco (UFPE), Recife, PE, Brazil. michelle.rosa@ufpe.br.; Biochemistry Department, Federal University of Pernambuco (UFPE), Recife, PE, Brazil. michelle.rosa@ufpe.br., Leão HI; Laboratory of Immunomodulation and New Therapeutic Approaches (LINAT), Research Center in Immunomodulation and New Therapeutic Approaches Suely Galdino (Nupit SG), Federal University of Pernambuco (UFPE), Recife, PE, Brazil., Silva EDL; Laboratory of Immunomodulation and New Therapeutic Approaches (LINAT), Research Center in Immunomodulation and New Therapeutic Approaches Suely Galdino (Nupit SG), Federal University of Pernambuco (UFPE), Recife, PE, Brazil., Ferreira NT; Laboratory of Immunomodulation and New Therapeutic Approaches (LINAT), Research Center in Immunomodulation and New Therapeutic Approaches Suely Galdino (Nupit SG), Federal University of Pernambuco (UFPE), Recife, PE, Brazil., Albuquerque APB; Laboratory of Immunomodulation and New Therapeutic Approaches (LINAT), Research Center in Immunomodulation and New Therapeutic Approaches Suely Galdino (Nupit SG), Federal University of Pernambuco (UFPE), Recife, PE, Brazil., Duarte GS; Instituto Nacional de Infectologia Evandro Chagas: INI - Fiocruz, Rio de Janeiro, Brazil., Siqueira AM; Instituto Nacional de Infectologia Evandro Chagas: INI - Fiocruz, Rio de Janeiro, Brazil., Pereira MC; Laboratory of Immunomodulation and New Therapeutic Approaches (LINAT), Research Center in Immunomodulation and New Therapeutic Approaches Suely Galdino (Nupit SG), Federal University of Pernambuco (UFPE), Recife, PE, Brazil.; Physiology and Pharmacology Department, Federal University of Pernambuco (UFPE), Recife, PE, Brazil., Rêgo MJBM; Laboratory of Immunomodulation and New Therapeutic Approaches (LINAT), Research Center in Immunomodulation and New Therapeutic Approaches Suely Galdino (Nupit SG), Federal University of Pernambuco (UFPE), Recife, PE, Brazil.; Biochemistry Department, Federal University of Pernambuco (UFPE), Recife, PE, Brazil., Pitta MGR; Laboratory of Immunomodulation and New Therapeutic Approaches (LINAT), Research Center in Immunomodulation and New Therapeutic Approaches Suely Galdino (Nupit SG), Federal University of Pernambuco (UFPE), Recife, PE, Brazil.; Biochemistry Department, Federal University of Pernambuco (UFPE), Recife, PE, Brazil. |
| المصدر: | Journal of neurovirology [J Neurovirol] 2023 Apr; Vol. 29 (2), pp. 180-186. Date of Electronic Publication: 2023 Jan 31. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer Country of Publication: United States NLM ID: 9508123 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1538-2443 (Electronic) Linking ISSN: 13550284 NLM ISO Abbreviation: J Neurovirol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2011- : New York : Springer Original Publication: Houndmills, Basingstoke, Hampshire ; New York, NY : Stockton Press, c1995- |
| مواضيع طبية MeSH: | COVID-19*, Humans ; Follow-Up Studies ; Brazil ; S100 Calcium Binding Protein beta Subunit ; SARS-CoV-2 ; Biomarkers ; Brain |
| مستخلص: | Neurological symptoms have been often reported in COVID-19 disease. In the present study, we evaluated brain damage associated with the increase of serum levels of neurological biomarkers S100B and neuron-specific enolase (NSE) induced by SARS-CoV-2 infection, in a population from Northeastern Brazil. Thirty-six healthy control (G1) individuals and 141 patients with confirmed COVID-19 were enrolled in this study. Positive-COVID-19 patients were divided into two groups according to the severity of illness by the National Institute of Health (NIH) criteria, 76 patients with mild symptoms for COVID-19 and (G2) and 65 with acute respiratory conditions requiring supplemental oxygenation via intensive care unit (ICU) admission (G3). A follow-up study was conducted with 23 patients from G2 14 (D14) and 21 (D21) days after the onset of symptoms. Serum levels of NSE and S100B were measured using the enzyme-linked immunoassay method (ELISA). Results revealed a significant positive association between G3 patients and S100B serum expression (p = 0.0403). The serum levels of NSE were also significantly enhanced in the G3 group compared to the control (p < 0.0001) and G2 group (p < 0.0001). In addition, clinical features such as symptoms and oxygenation status were not correlated with NSE or S100B serum expression. The follow-up study demonstrated a decrease over time (21 days) in NSE serum expression (p < 0.0001). These results suggest that brain damage is followed by acute virus exposure, with no long-term effects. Future work examining COVID-19 recovery will shed light on chronic neurological damage of SARS-CoV-2 infection. (© 2023. The Author(s) under exclusive licence to The Journal of NeuroVirology, Inc.) |
| References: | Sci Rep. 2020 Oct 29;10(1):18665. (PMID: 33122776) Neurobiol Dis. 2020 Dec;146:105131. (PMID: 33053430) Stroke. 2021 Jan;52(1):260-270. (PMID: 33161843) Acta Neurochir (Wien). 2017 Feb;159(2):209-225. (PMID: 27957604) In Vivo. 2021 Sep-Oct;35(5):2923-2928. (PMID: 34410988) PLoS One. 2021 May 19;16(5):e0251819. (PMID: 34010310) Neurosci Biobehav Rev. 2021 Aug;127:446-458. (PMID: 33971224) Crit Care. 2016 Sep 08;20:285. (PMID: 27604350) Int J Mol Sci. 2021 Mar 06;22(5):. (PMID: 33800954) BMC Emerg Med. 2018 Nov 20;18(1):44. (PMID: 30458714) Otolaryngol Head Neck Surg. 2020 Jul;163(1):132-134. (PMID: 32340555) Lancet. 2020 Feb 15;395(10223):507-513. (PMID: 32007143) Clin Chem. 2003 May;49(5):836-7. (PMID: 12709387) J Neurol Sci. 2015 Dec 15;359(1-2):202-6. (PMID: 26671113) Int J Neurosci. 2022 Mar;132(3):313-321. (PMID: 32772615) Biochem Biophys Res Commun. 2005 Mar 4;328(1):335-41. (PMID: 15670788) Sci Rep. 2020 Apr 14;10(1):6332. (PMID: 32286436) Cureus. 2020 Oct 19;12(10):e11033. (PMID: 33214960) Nat Neurosci. 2021 Feb;24(2):168-175. (PMID: 33257876) J Neurol Sci. 2022 Aug 15;439:120324. (PMID: 35752131) Adv Exp Med Biol. 2015;867:125-43. (PMID: 26530364) J Med Virol. 2021 Jan;93(1):206-222. (PMID: 32558956) J Med Virol. 2020 Oct;92(10):2036-2041. (PMID: 32347972) eNeurologicalSci. 2022 Dec;29:100434. (PMID: 36348961) J Neuroinflammation. 2021 Nov 27;18(1):277. (PMID: 34838058) |
| فهرسة مساهمة: | Keywords: Biomarker; COVID-19; Follow-up; NSE; S100B |
| المشرفين على المادة: | 0 (S100 Calcium Binding Protein beta Subunit) 0 (Biomarkers) |
| تواريخ الأحداث: | Date Created: 20230131 Date Completed: 20230517 Latest Revision: 20230611 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC9888322 |
| DOI: | 10.1007/s13365-023-01119-1 |
| PMID: | 36719594 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1538-2443 |
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| DOI: | 10.1007/s13365-023-01119-1 |