The BDNF Val66Met Polymorphism is a Relevant, But not Determinant, Risk Factor in the Etiology of Neuropsychiatric Disorders - Current Advances in Human Studies: A Systematic Review.
العنوان: | The BDNF Val66Met Polymorphism is a Relevant, But not Determinant, Risk Factor in the Etiology of Neuropsychiatric Disorders - Current Advances in Human Studies: A Systematic Review. |
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المؤلفون: | de Assis GG; Laboratory of Endocrinology, Brain Institute, Federal University of Rio Grande do Norte, Brazil.; Gdansk University of Physical Education and Sports, Faculty of Physical Education, Gdansk, Poland., Hoffman JR; Department of Physical Therapy, Ariel University, Ariel, Israel. |
المصدر: | Brain plasticity (Amsterdam, Netherlands) [Brain Plast] 2022 Dec 20; Vol. 8 (2), pp. 133-142. Date of Electronic Publication: 2022 Dec 20 (Print Publication: 2022). |
نوع المنشور: | Systematic Review |
اللغة: | English |
بيانات الدورية: | Publisher: IOS Press Country of Publication: Netherlands NLM ID: 101669568 Publication Model: eCollection Cited Medium: Internet ISSN: 2213-6312 (Electronic) Linking ISSN: 22136304 NLM ISO Abbreviation: Brain Plast Subsets: PubMed not MEDLINE |
أسماء مطبوعة: | Original Publication: Amsterdam : IOS Press, [2015]- |
مستخلص: | Brain-derived neurotrophic factor (BDNF) is the brain's most-produced neurotrophin during the lifespan, essentially involved in multiple mechanisms of nervous system development and function. The production/release of BDNF requires multi-stage processing that appears to be regulated at various stages in which the presence of a polymorphism "Val66Met" can exert a critical influence. Aim: To synthesize the knowledge on the BDNF Val66Met polymorphism on intracellular processing and function of BDNF. Methods: We performed a systematic review and collected all available studies on the post-translation processes of BDNF, regarding the Val66Met polymorphism. Searches were performed up to 21st March 2021. Results: Out of 129 eligible papers, 18 studies addressed or had findings relating to BDNF post-translation processes and were included in this review. Discussion: Compilation of experimental findings reveals that the Val66Met polymorphism affects BDNF function by slightly altering the processing, distribution, and regulated release of BDNF. Regarding the critical role of pro-BDNF as a pro-apoptotic factor, such alteration might represent a risk for the development of neuropsychiatric disorders. Competing Interests: We have no conflict of interest to declare. (© 2022 – The authors. Published by IOS Press.) |
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فهرسة مساهمة: | Keywords: BDNF secretion; Brain development; Neuroplasticity; Post-translation; Val66Met polymorphism; pro-BDNF cleavage |
تواريخ الأحداث: | Date Created: 20230201 Latest Revision: 20230202 |
رمز التحديث: | 20231215 |
مُعرف محوري في PubMed: | PMC9837733 |
DOI: | 10.3233/BPL-210132 |
PMID: | 36721394 |
قاعدة البيانات: | MEDLINE |
تدمد: | 2213-6312 |
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DOI: | 10.3233/BPL-210132 |