The BDNF Val66Met Polymorphism is a Relevant, But not Determinant, Risk Factor in the Etiology of Neuropsychiatric Disorders - Current Advances in Human Studies: A Systematic Review.
| العنوان: | The BDNF Val66Met Polymorphism is a Relevant, But not Determinant, Risk Factor in the Etiology of Neuropsychiatric Disorders - Current Advances in Human Studies: A Systematic Review. |
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| المؤلفون: | de Assis GG; Laboratory of Endocrinology, Brain Institute, Federal University of Rio Grande do Norte, Brazil.; Gdansk University of Physical Education and Sports, Faculty of Physical Education, Gdansk, Poland., Hoffman JR; Department of Physical Therapy, Ariel University, Ariel, Israel. |
| المصدر: | Brain plasticity (Amsterdam, Netherlands) [Brain Plast] 2022 Dec 20; Vol. 8 (2), pp. 133-142. Date of Electronic Publication: 2022 Dec 20 (Print Publication: 2022). |
| نوع المنشور: | Systematic Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: IOS Press Country of Publication: Netherlands NLM ID: 101669568 Publication Model: eCollection Cited Medium: Internet ISSN: 2213-6312 (Electronic) Linking ISSN: 22136304 NLM ISO Abbreviation: Brain Plast Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: Amsterdam : IOS Press, [2015]- |
| مستخلص: | Brain-derived neurotrophic factor (BDNF) is the brain's most-produced neurotrophin during the lifespan, essentially involved in multiple mechanisms of nervous system development and function. The production/release of BDNF requires multi-stage processing that appears to be regulated at various stages in which the presence of a polymorphism "Val66Met" can exert a critical influence. Aim: To synthesize the knowledge on the BDNF Val66Met polymorphism on intracellular processing and function of BDNF. Methods: We performed a systematic review and collected all available studies on the post-translation processes of BDNF, regarding the Val66Met polymorphism. Searches were performed up to 21st March 2021. Results: Out of 129 eligible papers, 18 studies addressed or had findings relating to BDNF post-translation processes and were included in this review. Discussion: Compilation of experimental findings reveals that the Val66Met polymorphism affects BDNF function by slightly altering the processing, distribution, and regulated release of BDNF. Regarding the critical role of pro-BDNF as a pro-apoptotic factor, such alteration might represent a risk for the development of neuropsychiatric disorders. Competing Interests: We have no conflict of interest to declare. (© 2022 – The authors. Published by IOS Press.) |
| References: | Nutr Neurosci. 2019 Jul;22(7):513-521. (PMID: 29280414) Trends Cell Biol. 2014 Oct;24(10):584-93. (PMID: 24841758) Int Clin Psychopharmacol. 2011 Jan;26(1):1-10. (PMID: 21188787) Neuropharmacology. 2014 Jan;76 Pt C:664-76. (PMID: 23831365) J Affect Disord. 2015 Apr 1;175:233-40. (PMID: 25658497) Front Mol Neurosci. 2010 Feb 09;3:1. (PMID: 20162032) Transl Psychiatry. 2016 Nov 22;6(11):e958. (PMID: 27874848) J Cell Sci. 2004 Jan 26;117(Pt 3):381-8. (PMID: 14702384) Curr Opin Cell Biol. 2018 Aug;53:9-14. (PMID: 29631154) Hypertension. 2001 Mar;37(3):898-906. (PMID: 11244015) J Cell Sci. 2016 Apr 1;129(7):1378-90. (PMID: 26869227) J Neurosci Res. 2004 Mar 15;75(6):825-34. (PMID: 14994343) Int J Med Sci. 2016 Dec 8;13(12):977-983. (PMID: 27994504) J Neurosci Res. 2000 Dec 15;62(6):830-9. (PMID: 11107168) Cell Tissue Res. 2020 Oct;382(1):15-45. (PMID: 32944867) Front Mol Neurosci. 2021 May 05;14:638176. (PMID: 34025349) Neuroscientist. 2019 Oct;25(5):434-454. (PMID: 30387693) Exp Brain Res. 2020 Jan;238(1):111-119. (PMID: 31802149) J Neurosci. 2005 Jun 1;25(22):5455-63. (PMID: 15930396) J Neuroendocrinol. 2004 Jan;16(1):19-25. (PMID: 14962071) Curr Protein Pept Sci. 2016;17(4):298-305. (PMID: 26100281) Dev Neurobiol. 2007 Feb 15;67(3):326-38. (PMID: 17443791) Front Neuroendocrinol. 2019 Oct;55:100784. (PMID: 31425696) Psychoneuroendocrinology. 2011 Nov;36(10):1562-9. (PMID: 21596481) FEBS Lett. 1996 Feb 5;379(3):247-50. (PMID: 8603699) J Biol Chem. 2001 Apr 20;276(16):12660-6. (PMID: 11152678) Neuromolecular Med. 2009;11(1):1-12. (PMID: 18946637) CNS Neurosci Ther. 2019 Mar;25(3):303-313. (PMID: 30403004) Mol Psychiatry. 2017 Oct;22(10):1370-1375. (PMID: 28937692) PLoS One. 2014 Mar 26;9(3):e92416. (PMID: 24670989) J Biol Chem. 2011 Aug 26;286(34):29556-67. (PMID: 21730062) Biol Psychiatry. 2013 Jun 1;73(11):1059-63. (PMID: 23312562) Mol Psychiatry. 2005 Feb;10(2):208-12. (PMID: 15630410) J Neurosci. 2003 Jul 16;23(15):6188-99. (PMID: 12867502) J Cell Sci. 2013 Dec 1;126(Pt 23):5412-21. (PMID: 24046442) Trans Am Clin Climatol Assoc. 2015;126:9-19. (PMID: 26330656) Am J Physiol Lung Cell Mol Physiol. 2016 Aug 1;311(2):L270-9. (PMID: 27317689) Neuroscience. 2009 Sep 15;162(4):1001-10. (PMID: 19497353) Genomics. 1991 Jul;10(3):558-68. (PMID: 1889806) Int J Neuropsychopharmacol. 2010 Feb;13(1):93-101. (PMID: 19236730) Science. 2001 Nov 30;294(5548):1945-8. (PMID: 11729324) J Neurosci. 2004 May 5;24(18):4401-11. (PMID: 15128854) Ann Allergy Asthma Immunol. 2018 Jun;120(6):631-640.e11. (PMID: 29567358) Neuron. 2005 Nov 23;48(4):619-33. (PMID: 16301178) Nat Rev Neurosci. 2013 Jan;14(1):7-23. (PMID: 23254191) J Neurosci. 1999 Mar 15;19(6):2069-80. (PMID: 10066260) Nat Commun. 2013;4:2490. (PMID: 24048383) J Biol Chem. 1996 Oct 11;271(41):25430-7. (PMID: 8810312) Psychoneuroendocrinology. 2009 Oct;34(9):1380-9. (PMID: 19473771) Database (Oxford). 2018 Jan 1;2018:. (PMID: 30576484) J Cell Biol. 2012 Mar 19;196(6):775-88. (PMID: 22412021) Cell Tissue Res. 2020 Oct;382(1):125-134. (PMID: 32897423) Development. 2007 Dec;134(24):4369-80. (PMID: 18003743) Prog Neuropsychopharmacol Biol Psychiatry. 2011 Jun 1;35(4):1022-5. (PMID: 21338649) Handb Exp Pharmacol. 2014;220:223-50. (PMID: 24668475) Endocr Rev. 1999 Feb;20(1):3-21. (PMID: 10047971) Dev Neurobiol. 2008 Sep 1;68(10):1243-56. (PMID: 18563704) Physiol Genomics. 2016 Feb;48(2):116-23. (PMID: 26603150) Brain Stimul. 2018 Sep - Oct;11(5):1123-1131. (PMID: 29802070) Cell. 2003 Jan 24;112(2):257-69. (PMID: 12553913) Proc Natl Acad Sci U S A. 2015 Feb 10;112(6):1880-5. (PMID: 25583515) Cytoskeleton (Hoboken). 2016 Oct;73(10):612-628. (PMID: 27223597) Pflugers Arch. 2017 Jun;469(5-6):593-610. (PMID: 28280960) Int J Mol Sci. 2017 May 12;18(5):. (PMID: 28498321) Neuropharmacology. 2014 Jan;76 Pt C:639-56. (PMID: 23602987) Neuron. 2007 Jul 5;55(1):53-68. (PMID: 17610817) J Neurosci. 2015 Jul 01;35(26):9741-53. (PMID: 26134656) F1000Res. 2019 Sep 19;8:. (PMID: 31583078) Am J Med Genet B Neuropsychiatr Genet. 2004 Apr 1;126B(1):122-3. (PMID: 15048661) |
| فهرسة مساهمة: | Keywords: BDNF secretion; Brain development; Neuroplasticity; Post-translation; Val66Met polymorphism; pro-BDNF cleavage |
| تواريخ الأحداث: | Date Created: 20230201 Latest Revision: 20230202 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC9837733 |
| DOI: | 10.3233/BPL-210132 |
| PMID: | 36721394 |
| قاعدة البيانات: | MEDLINE |
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