دورية أكاديمية
Protective Effects of Flavonoid Rutin Against Aminochrome Neurotoxicity.
العنوان: | Protective Effects of Flavonoid Rutin Against Aminochrome Neurotoxicity. |
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المؤلفون: | De Araújo FM; Laboratory of Neurochemistry and Cell Biology, Department of Biochemistry and Biophysics, Institute of Health Sciences, Federal University of Bahia, Salvador, Brazil.; Clinical & Experimental Neuroscience (NiCE). Institute for Bio-Health Research of Murcia (IMIB), Institute for Aging Research (IUIE), School of Medicine, Campus Mare Nostrum, University of Murcia, Murcia, Spain., Frota AF; Laboratory of Neurochemistry and Cell Biology, Department of Biochemistry and Biophysics, Institute of Health Sciences, Federal University of Bahia, Salvador, Brazil., de Jesus LB; Laboratory of Neurochemistry and Cell Biology, Department of Biochemistry and Biophysics, Institute of Health Sciences, Federal University of Bahia, Salvador, Brazil., Cuenca-Bermejo L; Clinical & Experimental Neuroscience (NiCE). Institute for Bio-Health Research of Murcia (IMIB), Institute for Aging Research (IUIE), School of Medicine, Campus Mare Nostrum, University of Murcia, Murcia, Spain., Ferreira KMS; Laboratory of Neurochemistry and Cell Biology, Department of Biochemistry and Biophysics, Institute of Health Sciences, Federal University of Bahia, Salvador, Brazil., Santos CC; Laboratory of Neurochemistry and Cell Biology, Department of Biochemistry and Biophysics, Institute of Health Sciences, Federal University of Bahia, Salvador, Brazil., Soares EN; Laboratory of Neurochemistry and Cell Biology, Department of Biochemistry and Biophysics, Institute of Health Sciences, Federal University of Bahia, Salvador, Brazil., Souza JT; Laboratory of Neurochemistry and Cell Biology, Department of Biochemistry and Biophysics, Institute of Health Sciences, Federal University of Bahia, Salvador, Brazil., Sanches FS; Laboratory of Neurochemistry and Cell Biology, Department of Biochemistry and Biophysics, Institute of Health Sciences, Federal University of Bahia, Salvador, Brazil., Costa ACS; Laboratory of Neurochemistry and Cell Biology, Department of Biochemistry and Biophysics, Institute of Health Sciences, Federal University of Bahia, Salvador, Brazil., Farias AA; Laboratory of Neurochemistry and Cell Biology, Department of Biochemistry and Biophysics, Institute of Health Sciences, Federal University of Bahia, Salvador, Brazil., de Fatima Dias Costa M; Laboratory of Neurochemistry and Cell Biology, Department of Biochemistry and Biophysics, Institute of Health Sciences, Federal University of Bahia, Salvador, Brazil., Munoz P; Instituto de Ciencias Biomedicas, Faculdad de Ciencias de la Salud, Universidad Autónoma de Chile, Santiago, Chile.; Molecular & Clinical Pharmacology, ICBM, Faculty of Medicine, University of Chile, Independencia, 1027, Santiago, Chile., Menezes-Filho JA; Graduate Program in Pharmacy, College of Pharmacy, Federal University of Bahia, Salvador, Brazil., Segura-Aguilar J; Molecular & Clinical Pharmacology, ICBM, Faculty of Medicine, University of Chile, Independencia, 1027, Santiago, Chile., Costa SL; Laboratory of Neurochemistry and Cell Biology, Department of Biochemistry and Biophysics, Institute of Health Sciences, Federal University of Bahia, Salvador, Brazil., Herrero MT; Clinical & Experimental Neuroscience (NiCE). Institute for Bio-Health Research of Murcia (IMIB), Institute for Aging Research (IUIE), School of Medicine, Campus Mare Nostrum, University of Murcia, Murcia, Spain. mtherrer@um.es., Silva VDA; Laboratory of Neurochemistry and Cell Biology, Department of Biochemistry and Biophysics, Institute of Health Sciences, Federal University of Bahia, Salvador, Brazil. vdsilva@ufba.br. |
المصدر: | Neurotoxicity research [Neurotox Res] 2023 Jun; Vol. 41 (3), pp. 224-241. Date of Electronic Publication: 2023 Feb 01. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Springer Country of Publication: United States NLM ID: 100929017 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-3524 (Electronic) Linking ISSN: 10298428 NLM ISO Abbreviation: Neurotox Res Subsets: MEDLINE |
أسماء مطبوعة: | Publication: <2009-> : New York : Springer Original Publication: [Amsterdam?] : Harwood Academic Publishers, |
مواضيع طبية MeSH: | Neurotoxicity Syndromes*/drug therapy , Neurotoxicity Syndromes*/prevention & control , Neurotoxicity Syndromes*/metabolism , Parkinson Disease*/metabolism , Neuroprotective Agents*/therapeutic use, Animals ; Mice ; Glial Cell Line-Derived Neurotrophic Factor/metabolism ; Flavonoids/pharmacology ; Rutin/pharmacology ; Dopamine/metabolism ; Dopaminergic Neurons ; Anti-Inflammatory Agents/pharmacology ; Disease Models, Animal ; Mice, Inbred C57BL ; 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine/pharmacology |
مستخلص: | Causes of dopaminergic neuronal loss in Parkinson's disease (PD) are subject of investigation and the common use of models of acute neurodegeneration induced by neurotoxins 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), 6-hydroxydopamine, and rotenone contributed to advances in the study of PD. However, the use of study models more similar to the pathophysiology of PD is required for advances in early diagnosis and translational pharmacology. Aminochrome (AMI), a compound derived from dopamine oxidation and a precursor of neuromelanin, is able to induce all the mechanisms associated with neurodegeneration. Previously, we showed AMI is cytotoxic in primary culture of mesencephalic cells (PCMC) and induces in vitro and in vivo neuroinflammation. On the other hand, the effect of rutin in central nervous system cells has revealed anti-inflammatory, antioxidative, and neuroprotective potential. However, there have been no data studies on the effect of rutin against aminochrome neurotoxicity. Here, we show that rutin prevents lysosomal dysfunction and aminochrome-induced cell death in SHSY-5Y cells, protects PCMC against aminochrome cytotoxicity, and prevents in vivo loss of dopaminergic neurons in substantia nigra pars compacta (SNPc), as well as microgliosis and astrogliosis. Additionally, we show that rutin decreases levels of interleukin-1β (IL-1β) mRNA and increases levels of glia-derived neurotrophic factor (GDNF) and nerve-derived neurotrophic factor (NGF) mRNA. We evidence for the first time the protective effect of rutin on PD aminochrome-induced models and suggest the potential role of the anti-inflammatory activity and upregulation of NGF and GDNF in the mechanism of rutin action against aminochrome neurotoxicity. (© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.) |
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فهرسة مساهمة: | Keywords: Dopamine; Neuroinflammation; Neuroprotection; Parkinson’s disease; Rutin |
المشرفين على المادة: | 39984-17-3 (aminochrome 1) 0 (Glial Cell Line-Derived Neurotrophic Factor) 0 (Flavonoids) 5G06TVY3R7 (Rutin) VTD58H1Z2X (Dopamine) 0 (Anti-Inflammatory Agents) 0 (Neuroprotective Agents) 9P21XSP91P (1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine) |
تواريخ الأحداث: | Date Created: 20230201 Date Completed: 20230508 Latest Revision: 20230508 |
رمز التحديث: | 20231215 |
DOI: | 10.1007/s12640-022-00616-1 |
PMID: | 36723781 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1476-3524 |
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DOI: | 10.1007/s12640-022-00616-1 |