دورية أكاديمية
أعرض في EDS

Single-cell spatial immune landscapes of primary and metastatic brain tumours.

التفاصيل البيبلوغرافية
العنوان: Single-cell spatial immune landscapes of primary and metastatic brain tumours.
المؤلفون: Karimi E; Rosalind and Morris Goodman Cancer Institute, McGill University, Montreal, Quebec, Canada., Yu MW; Rosalind and Morris Goodman Cancer Institute, McGill University, Montreal, Quebec, Canada.; Department of Physiology, Faculty of Medicine, McGill University, Montreal, Quebec, Canada., Maritan SM; Rosalind and Morris Goodman Cancer Institute, McGill University, Montreal, Quebec, Canada.; Department of Medicine, Division of Experimental Medicine, McGill University, Montreal, Quebec, Canada., Perus LJM; Rosalind and Morris Goodman Cancer Institute, McGill University, Montreal, Quebec, Canada.; Department of Physiology, Faculty of Medicine, McGill University, Montreal, Quebec, Canada., Rezanejad M; Departments of Psychology and Computer Science, University of Toronto, Toronto, Ontario, Canada., Sorin M; Rosalind and Morris Goodman Cancer Institute, McGill University, Montreal, Quebec, Canada.; Department of Human Genetics, Faculty of Medicine, McGill University, Montreal, Quebec, Canada., Dankner M; Rosalind and Morris Goodman Cancer Institute, McGill University, Montreal, Quebec, Canada.; Department of Medicine, Division of Experimental Medicine, McGill University, Montreal, Quebec, Canada., Fallah P; Gerald Bronfman Department of Oncology, McGill University, Montreal, Quebec, Canada., Doré S; Rosalind and Morris Goodman Cancer Institute, McGill University, Montreal, Quebec, Canada.; Department of Human Genetics, Faculty of Medicine, McGill University, Montreal, Quebec, Canada., Zuo D; Rosalind and Morris Goodman Cancer Institute, McGill University, Montreal, Quebec, Canada., Fiset B; Rosalind and Morris Goodman Cancer Institute, McGill University, Montreal, Quebec, Canada., Kloosterman DJ; Division of Tumor Biology and Immunology, Oncode Institute, Netherlands Cancer Institute, Amsterdam, Netherlands., Ramsay L; Rosalind and Morris Goodman Cancer Institute, McGill University, Montreal, Quebec, Canada., Wei Y; Rosalind and Morris Goodman Cancer Institute, McGill University, Montreal, Quebec, Canada., Lam S; Department of Diagnostic Radiology, Faculty of Medicine, McGill University, Montreal, Quebec, Canada., Alsajjan R; Department of Medicine, Division of Neurology, King Saud University College of Medicine, Riyadh, Saudi Arabia.; Department of Neurology and Neurosurgery, Faculty of Medicine, McGill University, Montreal, Quebec, Canada., Watson IR; Rosalind and Morris Goodman Cancer Institute, McGill University, Montreal, Quebec, Canada.; Department of Biochemistry, Faculty of Medicine, McGill University, Montreal, Quebec, Canada., Roldan Urgoiti G; Department of Oncology, University of Calgary, Calgary, Alberta, Canada.; Arnie Charbonneau Cancer Institute, University of Calgary, Calgary, Alberta, Canada., Park M; Rosalind and Morris Goodman Cancer Institute, McGill University, Montreal, Quebec, Canada.; Gerald Bronfman Department of Oncology, McGill University, Montreal, Quebec, Canada.; Department of Biochemistry, Faculty of Medicine, McGill University, Montreal, Quebec, Canada., Brandsma D; Department of Neuro-Oncology, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, Netherlands., Senger DL; Gerald Bronfman Department of Oncology, McGill University, Montreal, Quebec, Canada.; Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Quebec, Canada., Chan JA; Arnie Charbonneau Cancer Institute, University of Calgary, Calgary, Alberta, Canada.; Department of Pathology and Laboratory Medicine, University of Calgary, Calgary, Alberta, Canada., Akkari L; Division of Tumor Biology and Immunology, Oncode Institute, Netherlands Cancer Institute, Amsterdam, Netherlands., Petrecca K; Department of Neurology and Neurosurgery, Faculty of Medicine, McGill University, Montreal, Quebec, Canada.; Montreal Neurological Institute-Hospital, McGill University Health Centre, Montreal, Quebec, Canada., Guiot MC; Rosalind and Morris Goodman Cancer Institute, McGill University, Montreal, Quebec, Canada.; Department of Neurology and Neurosurgery, Faculty of Medicine, McGill University, Montreal, Quebec, Canada.; Montreal Neurological Institute-Hospital, McGill University Health Centre, Montreal, Quebec, Canada.; Department of Pathology, Faculty of Medicine, McGill University, Montreal, Quebec, Canada., Siegel PM; Rosalind and Morris Goodman Cancer Institute, McGill University, Montreal, Quebec, Canada. peter.siegel@mcgill.ca.; Department of Medicine, Division of Experimental Medicine, McGill University, Montreal, Quebec, Canada. peter.siegel@mcgill.ca.; Department of Biochemistry, Faculty of Medicine, McGill University, Montreal, Quebec, Canada. peter.siegel@mcgill.ca.; Department of Anatomy and Cell Biology, Faculty of Medicine, McGill University, Montreal, Quebec, Canada. peter.siegel@mcgill.ca., Quail DF; Rosalind and Morris Goodman Cancer Institute, McGill University, Montreal, Quebec, Canada. daniela.quail@mcgill.ca.; Department of Physiology, Faculty of Medicine, McGill University, Montreal, Quebec, Canada. daniela.quail@mcgill.ca.; Department of Medicine, Division of Experimental Medicine, McGill University, Montreal, Quebec, Canada. daniela.quail@mcgill.ca., Walsh LA; Rosalind and Morris Goodman Cancer Institute, McGill University, Montreal, Quebec, Canada. logan.walsh@mcgill.ca.; Department of Human Genetics, Faculty of Medicine, McGill University, Montreal, Quebec, Canada. logan.walsh@mcgill.ca.
المصدر: Nature [Nature] 2023 Feb; Vol. 614 (7948), pp. 555-563. Date of Electronic Publication: 2023 Feb 01.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE
أسماء مطبوعة: Publication: Basingstoke : Nature Publishing Group
Original Publication: London, Macmillan Journals ltd.
مواضيع طبية MeSH: Brain Neoplasms*/immunology , Brain Neoplasms*/pathology , Brain Neoplasms*/secondary , Glioma*/immunology , Glioma*/pathology , Tumor Microenvironment*/immunology , Single-Cell Analysis*, Humans ; Brain/immunology ; Brain/pathology ; Glioblastoma/immunology ; Glioblastoma/pathology ; Macrophages/enzymology ; Neoplasm Metastasis ; Datasets as Topic
مستخلص: Single-cell technologies have enabled the characterization of the tumour microenvironment at unprecedented depth and have revealed vast cellular diversity among tumour cells and their niche. Anti-tumour immunity relies on cell-cell relationships within the tumour microenvironment 1,2 , yet many single-cell studies lack spatial context and rely on dissociated tissues 3 . Here we applied imaging mass cytometry to characterize the immunological landscape of 139 high-grade glioma and 46 brain metastasis tumours from patients. Single-cell analysis of more than 1.1 million cells across 389 high-dimensional histopathology images enabled the spatial resolution of immune lineages and activation states, revealing differences in immune landscapes between primary tumours and brain metastases from diverse solid cancers. These analyses revealed cellular neighbourhoods associated with survival in patients with glioblastoma, which we leveraged to identify a unique population of myeloperoxidase (MPO)-positive macrophages associated with long-term survival. Our findings provide insight into the biology of primary and metastatic brain tumours, reinforcing the value of integrating spatial resolution to single-cell datasets to dissect the microenvironmental contexture of cancer.
(© 2023. The Author(s).)
التعليقات: Comment in: Nat Immunol. 2023 Apr;24(4):565-566. (PMID: 36959293)
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المشرفين على المادة: EC 1.11.1.7 (MPO protein, human)
تواريخ الأحداث: Date Created: 20230201 Date Completed: 20230225 Latest Revision: 20230503
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC9931580
DOI: 10.1038/s41586-022-05680-3
PMID: 36725935
قاعدة البيانات: MEDLINE
الوصف
تدمد:1476-4687
DOI:10.1038/s41586-022-05680-3