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A coffee enriched with guarana, selenium, and l-carnitine (GSC) has nutrigenomic effects on oxi-inflammatory markers of relapsing-remitting multiple sclerosis patients: A pilot study.

التفاصيل البيبلوغرافية
العنوان: A coffee enriched with guarana, selenium, and l-carnitine (GSC) has nutrigenomic effects on oxi-inflammatory markers of relapsing-remitting multiple sclerosis patients: A pilot study.
المؤلفون: Teixeira CF; Laboratory of Biogenomics, Department of Morphology, Health Sciences Center, Federal University of Santa Maria, 1000 Roraima Av., Building 19, Camobi, Santa Maria, RS, 97105-900, Brazil., Azzolin VF; Laboratory of Biogenomics, Department of Morphology, Health Sciences Center, Federal University of Santa Maria, 1000 Roraima Av., Building 19, Camobi, Santa Maria, RS, 97105-900, Brazil. Electronic address: azzolinveronica@hotmail.com., Rodrigues Dos Passos G; Clinical Research Center of São Lucas Hospital, Pontifical Catholic University of Rio Grande do Sul, 6690 Ipiranga Av., 4th floor, Porto Alegre, RS, 90619-900, Brazil., Turra BO; Laboratory of Biogenomics, Department of Morphology, Health Sciences Center, Federal University of Santa Maria, 1000 Roraima Av., Building 19, Camobi, Santa Maria, RS, 97105-900, Brazil., Alves AO; Laboratory of Biogenomics, Department of Morphology, Health Sciences Center, Federal University of Santa Maria, 1000 Roraima Av., Building 19, Camobi, Santa Maria, RS, 97105-900, Brazil., Bressanim ACM; Clinical Research Center of São Lucas Hospital, Pontifical Catholic University of Rio Grande do Sul, 6690 Ipiranga Av., 4th floor, Porto Alegre, RS, 90619-900, Brazil., Canton LEL; Clinical Research Center of São Lucas Hospital, Pontifical Catholic University of Rio Grande do Sul, 6690 Ipiranga Av., 4th floor, Porto Alegre, RS, 90619-900, Brazil., Vieira Dos Santos AC; Clinical Research Center of São Lucas Hospital, Pontifical Catholic University of Rio Grande do Sul, 6690 Ipiranga Av., 4th floor, Porto Alegre, RS, 90619-900, Brazil., Mastella MH; Laboratory of Biogenomics, Department of Morphology, Health Sciences Center, Federal University of Santa Maria, 1000 Roraima Av., Building 19, Camobi, Santa Maria, RS, 97105-900, Brazil., Barbisan F; Laboratory of Biogenomics, Department of Morphology, Health Sciences Center, Federal University of Santa Maria, 1000 Roraima Av., Building 19, Camobi, Santa Maria, RS, 97105-900, Brazil., Ribeiro EE; Open University Foundation for the Third Age, 11430 Brazil Av., Santo Antônio, Manaus, AM, 69029-040, Brazil., Duarte T; Laboratory of Biogenomics, Department of Morphology, Health Sciences Center, Federal University of Santa Maria, 1000 Roraima Av., Building 19, Camobi, Santa Maria, RS, 97105-900, Brazil., Duarte MMMF; Lutheran University of Brazil, BR-287, S/N - Boca do Monte, Santa Maria, RS, 97030-080, Brazil., Bonotto NCA; Laboratory of Biogenomics, Department of Morphology, Health Sciences Center, Federal University of Santa Maria, 1000 Roraima Av., Building 19, Camobi, Santa Maria, RS, 97105-900, Brazil., Sato DK; Clinical Research Center of São Lucas Hospital, Pontifical Catholic University of Rio Grande do Sul, 6690 Ipiranga Av., 4th floor, Porto Alegre, RS, 90619-900, Brazil., da Cruz IBM; Laboratory of Biogenomics, Department of Morphology, Health Sciences Center, Federal University of Santa Maria, 1000 Roraima Av., Building 19, Camobi, Santa Maria, RS, 97105-900, Brazil.
المصدر: Multiple sclerosis and related disorders [Mult Scler Relat Disord] 2023 Mar; Vol. 71, pp. 104515. Date of Electronic Publication: 2023 Jan 13.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier B. V Country of Publication: Netherlands NLM ID: 101580247 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2211-0356 (Electronic) Linking ISSN: 22110348 NLM ISO Abbreviation: Mult Scler Relat Disord Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [Amsterdam] : Elsevier B. V.
مواضيع طبية MeSH: Multiple Sclerosis, Relapsing-Remitting*/diagnosis , Multiple Sclerosis*/drug therapy , Selenium*/therapeutic use , Paullinia*, Humans ; Coffee ; Pilot Projects ; Carnitine/therapeutic use ; Nutrigenomics ; Cytokines
مستخلص: Relapsing-remitting multiple sclerosis (RRMS) is the most common clinical course of multiple sclerosis (MS), characterized by a chronic inflammatory state and elevated levels of oxidative markers. Food supplements with potential anti-inflammatory, antioxidant and neuroprotective effects have been tested as possible adjuvants in the treatment of MS. In this sense, this pilot study was carried out with the aim of verifying whether a minimum daily dose of a guarana, selenium and l-carnitine (GSC) based multi supplement, mixed in cappuccino-type coffee, administered for 12 weeks to 28 patients with RRMS could differentially modulate oxidative blood markers (lipoperoxidation, protein carbonylation and DNA oxidation) and inflammatory blood markers (protein levels of cytokines IL-1β, IL-6, TNF-α, IFN-γ, IL-10, gene expression of these cytokines, and NLRP3 and CASP-1 molecules, and C-reactive protein levels). The results indicate that a low concentration of GSC is capable of decreasing the plasma levels of oxidized DNA and pro-inflammatory cytokines of RRMS patients. The results support further research into the action of GSC on clinical symptoms, not only in patients with MS, but also with other neurological conditions.
Competing Interests: Declarations of Competing Interest none.
(Copyright © 2023 Elsevier B.V. All rights reserved.)
فهرسة مساهمة: Keywords: Autoimmune disease; Cytokines; Food supplement; Inflammation; Neuroprotection; Oxidative stress
المشرفين على المادة: H6241UJ22B (Selenium)
0 (Coffee)
S7UI8SM58A (Carnitine)
0 (Cytokines)
تواريخ الأحداث: Date Created: 20230203 Date Completed: 20230404 Latest Revision: 20230404
رمز التحديث: 20240628
DOI: 10.1016/j.msard.2023.104515
PMID: 36736038
قاعدة البيانات: MEDLINE
الوصف
تدمد:2211-0356
DOI:10.1016/j.msard.2023.104515