دورية أكاديمية
أعرض في EDS

Corneal Transplantation for Infectious Keratitis: A Prospective Dutch Registry Study.

التفاصيل البيبلوغرافية
العنوان: Corneal Transplantation for Infectious Keratitis: A Prospective Dutch Registry Study.
المؤلفون: Veugen JMJ; University Eye Clinic, Maastricht University Medical Center+, Maastricht, the Netherlands.; School for Mental Health and Neuroscience (MHeNs), Maastricht University, Maastricht, the Netherlands.; Department of Medical Microbiology, Maastricht University Medical Centre+, Nutrim School of Nutrition and Translational Research in Metabolism, Maastricht, the Netherlands.; Care and Public Health Research Institute (CAPHRI), Maastricht University, Maastricht, the Netherlands., Dunker SL; University Eye Clinic, Maastricht University Medical Center+, Maastricht, the Netherlands.; School for Mental Health and Neuroscience (MHeNs), Maastricht University, Maastricht, the Netherlands., Wolffs PFG; Department of Medical Microbiology, Maastricht University Medical Centre+, Nutrim School of Nutrition and Translational Research in Metabolism, Maastricht, the Netherlands.; Care and Public Health Research Institute (CAPHRI), Maastricht University, Maastricht, the Netherlands., Savelkoul PHM; Department of Medical Microbiology, Maastricht University Medical Centre+, Nutrim School of Nutrition and Translational Research in Metabolism, Maastricht, the Netherlands.; Department of Medical Microbiology and Infection Control, Amsterdam Infection and Immunity Institute, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands., Winkens B; Department of Methodology and Statistics, Faculty of Health, Medicine and Life Sciences, Care and Public Health Research Institute (CAPHRI), Maastricht University, Maastricht, the Netherlands; and., van den Biggelaar FJHM; University Eye Clinic, Maastricht University Medical Center+, Maastricht, the Netherlands., Nuijts RMMA; University Eye Clinic, Maastricht University Medical Center+, Maastricht, the Netherlands.; School for Mental Health and Neuroscience (MHeNs), Maastricht University, Maastricht, the Netherlands.; Department of Ophthalmology, Zuyderland Medical Center, Heerlen, the Netherlands., Dickman MM; University Eye Clinic, Maastricht University Medical Center+, Maastricht, the Netherlands.; School for Mental Health and Neuroscience (MHeNs), Maastricht University, Maastricht, the Netherlands.
مؤلفون مشاركون: Netherlands Cornea Transplant Network (NCTN)
المصدر: Cornea [Cornea] 2023 Nov 01; Vol. 42 (11), pp. 1414-1421. Date of Electronic Publication: 2023 Feb 02.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 8216186 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1536-4798 (Electronic) Linking ISSN: 02773740 NLM ISO Abbreviation: Cornea Subsets: MEDLINE
أسماء مطبوعة: Publication: Hagerstown, MD : Lippincott Williams & Wilkins
Original Publication: New York, N.Y. : Masson Pub. USA, c1982-
مواضيع طبية MeSH: Corneal Transplantation* , Acanthamoeba Keratitis*/surgery , Eye Infections, Viral*, Humans ; Prospective Studies ; Keratoplasty, Penetrating/methods ; Treatment Outcome ; Visual Acuity ; Registries ; Graft Survival ; Retrospective Studies
مستخلص: Purpose: The aim of this study was to analyze real-world practice patterns and graft survival after corneal transplantation for infectious keratitis in the Netherlands.
Methods: All consecutive keratoplasties for infectious keratitis registered in the Netherlands Organ Transplant Registry were included. Graft survival was analyzed using Kaplan-Meier survival curves with Cox regression to compare the 3 most common pathogens with subgroup analysis for type and reason of transplantation, sex, and graft size. Multivariable analysis was performed using the same explanatory factors.
Results: Between 2007 and 2017, 1111 keratoplasties for infectious keratitis were registered in the Netherlands Organ Transplant Registry. The most common pathogens were viruses (n = 437), bacteria (n = 271), and Acanthamoeba (n = 121). Human leukocyte antigen (HLA) matching did not provide a significant survival benefit, whereas emergency procedures showed worse graft survival [hazard ratio (HR) = 0.40, P = 0.120; HR = 2.73, P < 0.001, respectively]. Graft size >8.5 mm was significantly worse than graft size 8.5 mm (HR = 2.062, P = 0.010). In therapeutic keratoplasty, graft survival was significantly worse for Acanthamoeba than viral keratitis (HR = 2.36, P = 0.008). In the multivariable model, adjusting for graft size, type, and reason for transplantation, viral and bacterial keratitis did not differ significantly in graft survival, and Acanthamoeba showed a significantly worse prognosis (vs. viral keratitis, HR = 2.30, P < 0.001; bacterial keratitis, HR = 2.65, P < 0.001).
Conclusions: Viral keratitis was the most common indication for transplantation, followed by bacterial and Acanthamoeba keratitis. HLA matching did not offer protection over elective non-HLA-matched procedures, whereas emergency procedures and grafts sized >8.5 mm showed poor survival. In optical keratoplasty, survival is high for all pathogens, whereas in therapeutic keratoplasty Acanthamoeba shows poor outcome.
Competing Interests: The authors have no funding or conflicts of interest to disclose.
(Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc.)
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فهرسة مساهمة: Investigator: MC Bartels; I Bleyen; YY Cheng; H van Cleynenbreugel; MRP Dhooge; M Dickman; BTH van Dooren; CA Eggink; STJM Gast; AJM Geerards; TA van Goor; YP Henry; MJ Jager; N de Koning-Tahzib; R Lapid-Gortzak; A van der Lelij; CM van Luijk; IJ van der Meulen; CP Nieuwendaal; RMMA Nuijts; S Nobacht; BJ Putting; L Remeijer; G van Rij; AWJ Rijneveld; J van Rooij; IEY Saelens; NTY Santana; CC Sterk; R Stoutenbeek; ML Tang; RHJ Wijdh; RPL Wisse; MJW Zaal
تواريخ الأحداث: Date Created: 20230204 Date Completed: 20231220 Latest Revision: 20231220
رمز التحديث: 20231220
مُعرف محوري في PubMed: PMC10538606
DOI: 10.1097/ICO.0000000000003218
PMID: 36737861
قاعدة البيانات: MEDLINE
الوصف
تدمد:1536-4798
DOI:10.1097/ICO.0000000000003218