دورية أكاديمية
DoE development of ionic gradient liposomes: A successful approach to improve encapsulation, prolong anesthesia and decrease the toxicity of etidocaine.
| العنوان: | DoE development of ionic gradient liposomes: A successful approach to improve encapsulation, prolong anesthesia and decrease the toxicity of etidocaine. |
|---|---|
| المؤلفون: | Oliveira JD; Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas (Unicamp), Campinas, SP, Brazil., Rodrigues da Silva GH; Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas (Unicamp), Campinas, SP, Brazil., de Moura LD; Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas (Unicamp), Campinas, SP, Brazil., Göethel G; Toxicology Laboratory, Pharmacy Faculty, Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil., Papini JZB; São Leopoldo Mandic Institute and Research Center, Campinas-São Paulo, Brazil., Casadei BR; Physics Institute, University of São Paulo, Brazil., Ribeiro LNM; Institute of Biotechnology Federal University of Uberlândia (UFU), Uberlândia, MG, Brazil., Cabeça LF; Department of Chemistry, Federal Technological University of Parana, Londrina, PR, Brazil., Garcia SC; Toxicology Laboratory, Pharmacy Faculty, Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil., Martinez EF; São Leopoldo Mandic Institute and Research Center, Campinas-São Paulo, Brazil., Tofoli GR; São Leopoldo Mandic Institute and Research Center, Campinas-São Paulo, Brazil., de Paula E; Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas (Unicamp), Campinas, SP, Brazil. Electronic address: depaula@unicamp.br. |
| المصدر: | International journal of pharmaceutics [Int J Pharm] 2023 Mar 05; Vol. 634, pp. 122672. Date of Electronic Publication: 2023 Feb 02. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier/North-Holland Biomedical Press Country of Publication: Netherlands NLM ID: 7804127 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3476 (Electronic) Linking ISSN: 03785173 NLM ISO Abbreviation: Int J Pharm Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Amsterdam, Elsevier/North-Holland Biomedical Press. |
| مواضيع طبية MeSH: | Liposomes*/chemistry , Anesthesia*, Rats ; Animals ; Etidocaine ; Anesthetics, Local ; Ions/chemistry |
| مستخلص: | Etidocaine (EDC) is a long-acting local anesthetic of the aminoamide family whose use was discontinued in 2008 for alleged toxicity issues. Ionic gradient liposomes (IGL) are nanostructured carriers for which an inner/outer gradient of ions increases drug upload. This work describes IGL Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2023 Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Drug delivery; Etidocaine; Ionic gradient liposomes; Local anesthetics; Toxicity |
| المشرفين على المادة: | 0 (Liposomes) I6CQM0F31V (Etidocaine) 0 (Anesthetics, Local) 0 (Ions) |
| تواريخ الأحداث: | Date Created: 20230204 Date Completed: 20230224 Latest Revision: 20230224 |
| رمز التحديث: | 20230224 |
| DOI: | 10.1016/j.ijpharm.2023.122672 |
| PMID: | 36738810 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1873-3476 |
|---|---|
| DOI: | 10.1016/j.ijpharm.2023.122672 |