[Effects of surgical procedures and general anesthesia exposure within 2 hours in early childhood on neurodevelopmental outcomes in school-age].

التفاصيل البيبلوغرافية
العنوان:	[Effects of surgical procedures and general anesthesia exposure within 2 hours in early childhood on neurodevelopmental outcomes in school-age].
المؤلفون:	Wang JS; Department of Anesthesiology, Drum Tower Clinical College of Nanjing Medical University, Nanjing 210008, China Department of Anesthesiology, Children's Hospital of Nanjing Medical University, Nanjing 210008, China., Zhan WW; Department of Anesthesiology, Children's Hospital of Nanjing Medical University, Nanjing 210008, China., Fei J; Department of Anesthesiology, Children's Hospital of Nanjing Medical University, Nanjing 210008, China., Wang QQ; Department of Children Health Care, Children's Hospital of Nanjing Medical University, Nanjing 210008, China., Li YC; School of Public Health, Nanjing Medical University, Nanjing 211166, China., Gu XP; Department of Anesthesiology, Drum Tower Clinical College of Nanjing Medical University, Nanjing 210008, China.
المصدر:	Zhonghua yi xue za zhi [Zhonghua Yi Xue Za Zhi] 2023 Feb 07; Vol. 103 (5), pp. 356-363.
نوع المنشور:	English Abstract; Journal Article
اللغة:	Chinese
بيانات الدورية:	Publisher: Zhonghua yi xue hui Country of Publication: China NLM ID: 7511141 Publication Model: Print Cited Medium: Print ISSN: 0376-2491 (Print) Linking ISSN: 03762491 NLM ISO Abbreviation: Zhonghua Yi Xue Za Zhi Subsets: MEDLINE
أسماء مطبوعة:	Publication: Beijing : Zhonghua yi xue hui Original Publication: Beijing : Zhonghua yi xue hui.
مواضيع طبية MeSH:	Child Development* , Anesthesia, General*/adverse effects, Male ; Child ; Female ; Humans ; Child, Preschool ; Retrospective Studies ; Wechsler Scales
مستخلص:	Objective: To observe the effect of surgical procedures and general anesthesia exposure (<2 h) in early childhood on neurodevelopmental outcomes in school-age. Methods: A total of 147 children aged 6-12 years old, who received surgery under general anesthesia (<2 h) at the age of 0-2 years in Children's Hospital of Nanjing Medical Universityfrom June 2009 to December 2012 were retrospectively enrolled in this study (from June 2018 to December 2021) as exposure group, including 76 males and 71 females, with a mean age of (8.8±1.6) years. All the cases were divided into single-exposure group ( n =65) and multiple-exposure group (≥2 times, n =82) according to different times of anesthesia exposure. According to the cohort of exposure group, 160 healthy children of the same age with no history of surgery under general anesthesia were recruited from the community from June 2018 to December 2021 as the control group, including 87 males and 73 females, and aged (8.6±1.9) years. A variety of standardized neurological tests including Wechsler intelligence scale for children fourth edition (WSC-Ⅳ), integrated visual and auditory continuous performance test (IVA-CPT), Swanson Nolan and Pelham, version Ⅳ (SNAP-Ⅳ), children sensory integration capacity development rating scale (CSIC), and social living ability scale were performed in all subjects by a child health specialist who failed to know the details. The primary outcome was the full-scale IQ (FSIQ) in WISC-Ⅳ, and the secondary outcomes were IVA-CPT, SNAP-Ⅳ, CSIC, and social living ability scale. Results: The FSIQ of single-exposure, multiple-exposure and control groups was 105.4±14.1, 100.9±10.2 and 103.6±13.5, respectively, with no statistically significant difference ( F =2.37, P =0.095). The FSIQ of different first age exposure groups (aged 0-6 months, 7-12 months and 1-2 years) was 99.8±10.2, 104.5±10.5 and 104.4±14.5, respectively, with no statistically significant difference ( F =2.39, P =0.095). The FSIQ of different exposure duration groups (0-59 min, 60-119 min and control group) was 102.8±11.3, 103.0±13.7 and 103.6±13.5, respectively, with no statistically significant difference ( F =0.13, P =0.882). As for the secondary outcomes, the scores of visual persistence quotient in single-exposure, multiple-exposure and control groups were 94.8±10.5, 94.0±10.9 and 100.6±17.7, with a statistically significant difference ( F =6.96, P =0.001). In terms of locomotion in social living ability scale, the score of the three groups was 10.0±0.2, 10.2±0.6 and 10.4±0.7, respectively, with a statistically significant difference ( F =10.61, P <0.001), but all were within the standard range. Conclusions: The surgical procedures and general anesthesia exposure within 2 hours in early childhood has no effect on the overall FSIQ in school age, but has a slight impacts on the visual persistence quotient of IVA-CPT and the locomotion score of social living ability scale.
فهرسة مساهمة:	Local Abstract: [Publisher, Chinese] 目的：观察儿童早期2 h以内全身麻醉手术暴露对学龄期神经发育的影响。方法：回顾性选择2009年6月至2012年12月在南京医科大学附属儿童医院接受全身麻醉外科手术（时间<2 h）时0~2岁，且入选本研究时（2018年6月至2021年12月）为6~12岁的学龄期儿童为暴露组，共147例，其中男76例，女71例，年龄（8.8±1.6）岁；根据不同麻醉暴露次数分为单次暴露组（ n =65）和多次暴露组（≥2次， n =82）。按照暴露组队列匹配同期（2018年6月至2021年12月）社区招募的同龄、无全身麻醉手术史的健康儿童为健康对照组，共160名，其中男87名，女73名，年龄（8.6±1.9）岁。由专业儿童保健科医师对所有受试者进行多种标准化神经测试，包括韦氏儿童智力量表第四版中文版（WISC-Ⅳ）、整合视听连续执行测试（IVA-CPT）、注意缺陷多动障碍量表（SNAP-Ⅳ）、感觉统合能力发展量表中文版（CSIC）和社会生活能力量表。主要观察指标为WISC-Ⅳ中的全量表总智商（FSIQ），次要观察指标为IVA-CPT、SNAP-Ⅳ、CSIC和社会生活能力量表得分。结果：单次暴露组、多次暴露组和健康对照组FSIQ分别为105.4±14.1、100.9±10.2和103.6±13.5，差异无统计学意义（ F =2.37， P =0.095）；0~6个月、7~12个月和1~2岁首次暴露年龄组的FSIQ分别为99.8±10.2、104.5±10.5和104.4±14.5，差异无统计学意义（ F =2.39， P =0.095）；暴露0~59 min组、暴露60~119 min组和健康对照组FSIQ分别为102.8±11.3、103.0±13.7和103.6±13.5，差异无统计学意义（ F =0.13， P =0.882）。在次要观察结果中，单次暴露组、多次暴露组和健康对照组IVA-CPT的视觉持续性商数分别为94.8±10.5、94.0±10.9和100.6±17.7，差异有统计学意义（ F =6.96， P =0.001）；社会生活能力量表的运动得分分别为（10.0±0.2）、（10.2±0.6）和（10.4±0.7）分，差异有统计学意义（ F =10.61， P <0.001），但均在标准范围内。结论：儿童早期2 h以内的全身麻醉手术暴露对学龄期整体FSIQ没有影响，对IVA-CPT的视觉持续性商数以及社会生活能力量表的运动得分略有影响。.
تواريخ الأحداث:	Date Created: 20230205 Date Completed: 20230207 Latest Revision: 20230207
رمز التحديث:	20231215
DOI:	10.3760/cma.j.cn112137-20220524-01150
PMID:	36740394
قاعدة البيانات:	MEDLINE

الوصف
تدمد:	0376-2491
DOI:	10.3760/cma.j.cn112137-20220524-01150