دورية أكاديمية
Association of heme-oxygenase 1, hemopexin, and heme levels with markers of disease severity in COVID-19.
| العنوان: | Association of heme-oxygenase 1, hemopexin, and heme levels with markers of disease severity in COVID-19. |
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| المؤلفون: | de Lima F; School of Medical Sciences, University of Campinas, Campinas 13083-887, Brazil., Moraes CRP; School of Medical Sciences, University of Campinas, Campinas 13083-887, Brazil., Barbosa MS; School of Medical Sciences, University of Campinas, Campinas 13083-887, Brazil., Bombassaro B; Obesity and Comorbidities Research Center, University of Campinas, Campinas 13083-864, Brazil., Palma AC; School of Medical Sciences, University of Campinas, Campinas 13083-887, Brazil., Dertkigil SSJ; School of Medical Sciences, University of Campinas, Campinas 13083-887, Brazil., Moretti ML; School of Medical Sciences, University of Campinas, Campinas 13083-887, Brazil., Orsi FA; School of Medical Sciences, University of Campinas, Campinas 13083-887, Brazil., Annichino-Bizzacchi JM; School of Medical Sciences, University of Campinas, Campinas 13083-887, Brazil.; Hematology and Hemotherapy Center, University of Campinas, Campinas 13083-878, Brazil., Mansour E; School of Medical Sciences, University of Campinas, Campinas 13083-887, Brazil., Velloso LA; School of Medical Sciences, University of Campinas, Campinas 13083-887, Brazil.; Obesity and Comorbidities Research Center, University of Campinas, Campinas 13083-864, Brazil., De Paula EV; School of Medical Sciences, University of Campinas, Campinas 13083-887, Brazil.; Hematology and Hemotherapy Center, University of Campinas, Campinas 13083-878, Brazil. |
| المصدر: | Experimental biology and medicine (Maywood, N.J.) [Exp Biol Med (Maywood)] 2023 Feb; Vol. 248 (4), pp. 309-316. Date of Electronic Publication: 2023 Feb 05. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Frontiers Media S.A Country of Publication: England NLM ID: 100973463 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1535-3699 (Electronic) Linking ISSN: 15353699 NLM ISO Abbreviation: Exp Biol Med (Maywood) Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2024- : Lausanne, Switzerland : Frontiers Media S.A. Original Publication: Maywood, NJ : The Society, c2001- |
| مواضيع طبية MeSH: | COVID-19* , Heme*, Humans ; Biomarkers ; Hemopexin/metabolism ; Pandemics ; Patient Acuity ; Heme Oxygenase-1/metabolism |
| مستخلص: | Heme-oxygenase 1 (HO-1) is an enzyme with well-known anti-inflammatory and antioxidant properties, whose levels have been previously associated with disease severity in the context of sterile and infectious diseases. Moreover, the heme/HO-1 pathway has been associated with prothrombotic changes in other diseases. Accordingly, the potential of modulating HO-1 levels for the treatment of COVID-19 was extensively speculated during the COVID-19 pandemic, but very few actual data were generated. The aim of our study was to explore the association of HO-1, heme, and hemopexin (HPX) levels with COVID-19 severity and with markers of inflammation and coagulation activation. The study was conducted in 30 consecutive patients with COVID-19 admitted due to hypoxemia, and 30 healthy volunteers matched by sex, age, and geographic region. HO-1 and HPX levels were measured by enzyme immunoassay (ELISA) and heme levels were measured by a colorimetric method. A comprehensive panel of coagulation and fibrinolysis activation was also used. Patients with COVID-19 presented increased levels of HO-1 when compared to controls (5741 ± 2696 vs 1953 ± 612 pg/mL, respectively, P < 0.0001), as well as a trend toward increased levels of HPX (3.724 ± 0.880 vs 3.254 ± 1.022 mg/mL, respectively; P = 0.06). In addition, HO-1 and HPX levels reduced from admission to day + 4. HO-1 levels were associated with duration of intensive care unit stay and with several markers of coagulation activation. In conclusion, modulation of HO-1 could be associated with the prothrombotic state observed in COVID-19, and HO-1 could also represent a relevant biomarker for COVID-19. New independent studies are warranted to explore and expand these findings. |
| فهرسة مساهمة: | Keywords: COVID-19; Heme-oxygenase 1; coagulation; heme; hemopexin; inflammation |
| المشرفين على المادة: | 0 (Biomarkers) 42VZT0U6YR (Heme) 9013-71-2 (Hemopexin) EC 1.14.14.18 (Heme Oxygenase-1) |
| تواريخ الأحداث: | Date Created: 20230206 Date Completed: 20230505 Latest Revision: 20230512 |
| رمز التحديث: | 20230513 |
| مُعرف محوري في PubMed: | PMC9902789 |
| DOI: | 10.1177/15353702221139185 |
| PMID: | 36740756 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1535-3699 |
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| DOI: | 10.1177/15353702221139185 |