دورية أكاديمية
أعرض في EDS

Phytochemical Analysis, Antifungal, and Antioxidant Properties of Two Herbs ( Tristemma mauritianum and Crassocephalum bougheyanum ) and One Tree ( Lavigeria macrocarpa ) Species.

التفاصيل البيبلوغرافية
العنوان: Phytochemical Analysis, Antifungal, and Antioxidant Properties of Two Herbs ( Tristemma mauritianum and Crassocephalum bougheyanum ) and One Tree ( Lavigeria macrocarpa ) Species.
المؤلفون: Kengne IC; Research Unit of Microbiology and Antimicrobial Substances, Faculty of Sciences, University of Dschang, Dschang, P.O. Box 67, Cameroon., Fankam AG; Research Unit of Microbiology and Antimicrobial Substances, Faculty of Sciences, University of Dschang, Dschang, P.O. Box 67, Cameroon., Yamako EK; Département des Sciences Appliquées à la Santé, Institut Universitaire et Stratégique de l'Estuaire (IUEs/Insam), BP 4100, Douala, Cameroon., Tamokou JD; Research Unit of Microbiology and Antimicrobial Substances, Faculty of Sciences, University of Dschang, Dschang, P.O. Box 67, Cameroon.
المصدر: Advances in pharmacological and pharmaceutical sciences [Adv Pharmacol Pharm Sci] 2023 Jan 25; Vol. 2023, pp. 2565857. Date of Electronic Publication: 2023 Jan 25 (Print Publication: 2023).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Hindawi Country of Publication: England NLM ID: 101762941 Publication Model: eCollection Cited Medium: Internet ISSN: 2633-4690 (Electronic) Linking ISSN: 26334690 NLM ISO Abbreviation: Adv Pharmacol Pharm Sci Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: [London] : Hindawi, [2020]-
مستخلص: Phytochemicals present in medicinal plants (herbs, shrubs, and trees) are endowed with high antimicrobial and antioxidant properties. The aim of this work was to study the chemical composition, antioxidant, and antifungal activities of Tristemma mauritianum , Crassocephalum bougheyanum, and Lavigeria macrocarpa. Chemical composition of the plant extracts was determined using standard methods. The antioxidant activities were performed using 2,2-diphenyl-1-picrylhydrazyl (DPPH), ferric reducing antioxidant power (FRAP), nitric oxide (NO), and hydroxyl (OH) scavenging assays. The antifungal activity of plant extracts and their combinations with antifungals was evaluated against eleven Candida spp . using the broth microdilution method by determining the minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC). The quantitative chemical analysis of the extracts of T. mauritianum , L. macrocarpa, and C. bougheyanum showed that they contain phenols, tannins, and flavonoids that vary according to the plant species and extracts. All the plant extracts presented promising antifungal (MIC = 64-2048  µ g/mL) and antioxidant activities. The extract of T. mauritianum displayed the highest antifungal (MIC = 64-256  µ g/mL) and antioxidant (IC 50  = 19.052 ± 1.11  μ g/mL) activities which can be explained by its high phenolic content. Interestingly, extracts of T. mauritianum , L. macrocarpa , and C. bougheyanum displayed synergistic effects (fractional inhibitory concentration index, FICI ≤ 0.5) with ketoconazole against clinical resistant isolates. The results of the present study demonstrate promising antifungal and antioxidant activities of the tested plants that are associated to their phenol, tannin, and flavonoid contents. Hence, extracts of T. mauritianum and L. macrocarpa could be deeply investigated as antifungal alone and in combination with conventional antifungal drugs to treat infections caused by Candida spp .
Competing Interests: The authors declare that they have no conflicts of interest.
(Copyright © 2023 Irene Chinda Kengne et al.)
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تواريخ الأحداث: Date Created: 20230206 Latest Revision: 20230207
رمز التحديث: 20230207
مُعرف محوري في PubMed: PMC9891821
DOI: 10.1155/2023/2565857
PMID: 36742131
قاعدة البيانات: MEDLINE
الوصف
تدمد:2633-4690
DOI:10.1155/2023/2565857