دورية أكاديمية
Effect of invasive aspergillosis on risk for different causes of death in older patients with acute myeloid leukaemia or high-risk myelodysplastic syndrome.
| العنوان: | Effect of invasive aspergillosis on risk for different causes of death in older patients with acute myeloid leukaemia or high-risk myelodysplastic syndrome. |
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| المؤلفون: | van Grootveld R; Department of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands. r.van_grootveld@lumc.nl., Masarotto V; Mathematical Institute, Leiden University, Leiden, The Netherlands., von dem Borne PA; Department of Haematology, Leiden University Medical Center, Leiden, The Netherlands., Blijlevens NMA; Department of Haematology, Radboud University Medical Center, Nijmegen, The Netherlands., Chitu DA; Department of Haematology, Erasmus University Medical Center, Rotterdam, The Netherlands., van der Beek MT; Department of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands., Fiocco M; Mathematical Institute, Leiden University, Leiden, The Netherlands.; Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, The Netherlands., de Boer MGJ; Department of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands. |
| المصدر: | BMC infectious diseases [BMC Infect Dis] 2023 Feb 06; Vol. 23 (1), pp. 78. Date of Electronic Publication: 2023 Feb 06. |
| نوع المنشور: | Randomized Controlled Trial; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: BioMed Central Country of Publication: England NLM ID: 100968551 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2334 (Electronic) Linking ISSN: 14712334 NLM ISO Abbreviation: BMC Infect Dis Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: London : BioMed Central, [2001- |
| مواضيع طبية MeSH: | Leukemia, Myeloid, Acute*/complications , Leukemia, Myeloid, Acute*/drug therapy , Aspergillosis*/complications , Invasive Fungal Infections*/complications , Myelodysplastic Syndromes*/complications, Adult ; Humans ; Male ; Aged ; Female ; Cause of Death |
| مستخلص: | Purpose: Study objectives were to estimate the cumulative incidence of death due to different causes of death (CODs) and investigate the effect of invasive aspergillosis (IA) on each separate COD in a cohort of older patients with acute myeloid leukaemia (AML) or high-risk myelodysplastic syndrome (MDS) included in the Haemato-Oncology Foundation for Adults in the Netherlands (HOVON) 43 randomized controlled trial. Methods: Pre-collected data from the trial was obtained from the HOVON data center and relevant clinical information was extracted. The cumulative incidence of death due to different CODs was estimated with a competing risk model and the association between each COD and prognostic factors, including IA, were investigated with a cause-specific hazard Cox regression model. Results: In total 806 patients were included, mean age of 70 years and 55% were male. The cumulative incidences of death due to leukaemia or infection at 3, 6, 12 and 36 months were 0.06, 0.11, 0.23, 0.42 and 0.17, 0.19, 0.22, 0.25 respectively. Incidence of IA was 21% and diagnosis of IA up until the final chemotherapy cycle was associated with an increased risk of dying from leukaemia (cause-specific hazard ratio ( Conclusion: Leukaemia was the most likely cause of death over time, however in the first year after diagnosis of AML or high-risk MDS infection was the most likely cause of death. Patients with IA had a relatively increased risk of dying from leukaemia or infection. (© 2023. The Author(s).) |
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| فهرسة مساهمة: | Keywords: Acute myeloid leukaemia; Aged; Aspergillosis; Invasive fungal infection; Invasive pulmonary aspergillosis; Myelodysplastic syndromes |
| تواريخ الأحداث: | Date Created: 20230207 Date Completed: 20230208 Latest Revision: 20230209 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC9903459 |
| DOI: | 10.1186/s12879-023-08013-5 |
| PMID: | 36747127 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 1471-2334 |
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| DOI: | 10.1186/s12879-023-08013-5 |