التفاصيل البيبلوغرافية
| العنوان: |
The memory of pathogenic IgE is contained within CD23 + IgG1 + memory B cells poised to switch to IgE in food allergy. |
| المؤلفون: |
Ota M, Hoehn KB, Ota T, Aranda CJ, Friedman S, Braga WF, Malbari A, Kleinstein SH, Sicherer SH, Curotto de Lafaille MA |
| المصدر: |
BioRxiv : the preprint server for biology [bioRxiv] 2023 Jan 25. Date of Electronic Publication: 2023 Jan 25. |
| نوع المنشور: |
Preprint |
| اللغة: |
English |
| بيانات الدورية: |
Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE |
| مستخلص: |
Food allergy is caused by allergen-specific IgE antibodies but little is known about the B cell memory of persistent IgE responses. Here we describe in human pediatric peanut allergy CD23 + IgG1 + memory B cells arising in type 2 responses that contain peanut specific clones and generate IgE cells on activation. These 'type2-marked' IgG1 + memory B cells differentially express IL-4/IL-13 regulated genes FCER2 / CD23, IL4R , and germline IGHE and carry highly mutated B cell receptors (BCRs). Further, high affinity memory B cells specific for the main peanut allergen Ara h 2 mapped to the population of 'type2-marked' IgG1 + memory B cells and included convergent BCRs across different individuals. Our findings indicate that CD23 + IgG1 + memory B cells transcribing germline IGHE are a unique memory population containing precursors of pathogenic IgE.
One-Sentence Summary: We describe a unique population of IgG + memory B cells poised to switch to IgE that contains high affinity allergen-specific clones in peanut allergy. |
| التعليقات: |
Update in: Sci Transl Med. 2024 Feb 7;16(733):eadi0673. (PMID: 38324641) |
| معلومات مُعتمدة: |
K99 AI159302 United States AI NIAID NIH HHS; R01 AI130343 United States AI NIAID NIH HHS; R01 AI151707 United States AI NIAID NIH HHS |
| تواريخ الأحداث: |
Date Created: 20230207 Latest Revision: 20240403 |
| رمز التحديث: |
20240403 |
| مُعرف محوري في PubMed: |
PMC9900782 |
| DOI: |
10.1101/2023.01.25.525506 |
| PMID: |
36747707 |
| قاعدة البيانات: |
MEDLINE |
