دورية أكاديمية
أعرض في EDS

Maternal carriage of H-Y restricting HLA class II alleles is a negative prognostic factor for women with recurrent pregnancy loss after birth of a boy.

التفاصيل البيبلوغرافية
العنوان: Maternal carriage of H-Y restricting HLA class II alleles is a negative prognostic factor for women with recurrent pregnancy loss after birth of a boy.
المؤلفون: Nørgaard-Pedersen C; Centre for Recurrent Pregnancy loss of Western Denmark, Department of Obstetrics and Gynaecology, Aalborg University Hospital, Reberbansgade 15, 9000 Aalborg, Denmark; Department of Clinical Medicine, Søndre Skovvej 15, 9000 Aalborg, Denmark. Electronic address: c.noergaardpedersen@rn.dk., Steffensen R; Department of Clinical Immunology, Aalborg University Hospital, Urbansgade 32, 9000 Aalborg, Denmark. Electronic address: rsn@rn.dk., Kesmodel US; Centre for Recurrent Pregnancy loss of Western Denmark, Department of Obstetrics and Gynaecology, Aalborg University Hospital, Reberbansgade 15, 9000 Aalborg, Denmark; Department of Clinical Medicine, Søndre Skovvej 15, 9000 Aalborg, Denmark. Electronic address: u.kesmodel@rn.dk., Christiansen OB; Centre for Recurrent Pregnancy loss of Western Denmark, Department of Obstetrics and Gynaecology, Aalborg University Hospital, Reberbansgade 15, 9000 Aalborg, Denmark; Department of Clinical Medicine, Søndre Skovvej 15, 9000 Aalborg, Denmark. Electronic address: olbc@rn.dk.
المصدر: Journal of reproductive immunology [J Reprod Immunol] 2023 Mar; Vol. 156, pp. 103817. Date of Electronic Publication: 2023 Jan 24.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier/North-Holland Biomedical Press Country of Publication: Ireland NLM ID: 8001906 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7603 (Electronic) Linking ISSN: 01650378 NLM ISO Abbreviation: J Reprod Immunol Subsets: MEDLINE
أسماء مطبوعة: Publication: Limerick : Elsevier/North-Holland Biomedical Press
Original Publication: Amsterdam, Elsevier/North-Holland Biomedical Press.
مواضيع طبية MeSH: Abortion, Habitual* , H-Y Antigen*/genetics, Female ; Humans ; Male ; Pregnancy ; Alleles ; Histocompatibility ; HLA-DRB1 Chains/genetics ; Prognosis ; Histocompatibility Antigens Class II/immunology
مستخلص: Immune system aberrations are suggested to be an important factor in the pathophysiology of unexplained secondary recurrent pregnancy loss (sRPL). The objective was to investigate if the sex ratio of the firstborn child in sRPL patients differs from the background population and whether the sex of the firstborn child has a negative impact on the pregnancy prognosis alone and/or in combination with carriage of male-specific minor histocompatibility (H-Y) restricting HLA class II alleles. From January 2016 to October 2022, 582 patients with unexplained RPL were admitted to the RPL Center of Western Denmark and continuously followed-up. HLA-DRB1 and -DQB1 typing was performed as part of the routine diagnostic work-up. In sRPL patients, a history of a firstborn boy was significantly more frequent than in the Danish background population and was associated with significantly lower odds of a successful reproductive outcome in the first pregnancy after admission compared to a firstborn girl (OR=0.41, 95% CI: 0.20-0.83, p = 0.014). The odds of a successful reproductive outcome were enhanced in patients carrying ≥ 1 H-Y-restricting HLA class II alleles with a first-born girl compared to a firstborn boy (OR=3.33, 95% CI: 1.40-7.88, p = 0.005), while no difference in successful reproductive outcome was seen in sRPL patients not carrying these alleles (OR=1.20, 95% CI: 0.33-4.43, p = 0.781). The sex ratio of children born after RPL was similar to the Danish background population. These findings confirm previous findings and suggests that a harmful immune response triggered by H-Y-antigen exposure during a previous pregnancy in preconditioned women may cause sRPL.
Competing Interests: Declaration of interest None
(Copyright © 2023 The Authors. Published by Elsevier B.V. All rights reserved.)
فهرسة مساهمة: Keywords: Habitual abortion; Human leukocyte antigen; Immunogenetics; Male-specific minor histocompatibility antigen; Recurrent pregnancy loss
المشرفين على المادة: 0 (H-Y Antigen)
0 (HLA-DRB1 Chains)
0 (Histocompatibility Antigens Class II)
تواريخ الأحداث: Date Created: 20230208 Date Completed: 20230328 Latest Revision: 20230331
رمز التحديث: 20231215
DOI: 10.1016/j.jri.2023.103817
PMID: 36753935
قاعدة البيانات: MEDLINE
الوصف
تدمد:1872-7603
DOI:10.1016/j.jri.2023.103817