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In Vivo Toxicological Analysis of MnFe 2 O 4 @poly( t BGE-alt-PA) Composite as a Hybrid Nanomaterial for Possible Biomedical Use.

التفاصيل البيبلوغرافية
العنوان: In Vivo Toxicological Analysis of MnFe 2 O 4 @poly( t BGE-alt-PA) Composite as a Hybrid Nanomaterial for Possible Biomedical Use.
المؤلفون: Kumar R; Department of Life Sciences, Sharda School of Basic Sciences and Research, Sharda University, Greater Noida 201310 Uttar Pradesh, India., Bauri S; Department of Life Science, National Institute of Technology, Rourkela 769008 Odisha, India., Sahu S; Department of Life Science, National Institute of Technology, Rourkela 769008 Odisha, India., Chauhan S; Department of Life Sciences, Sharda School of Basic Sciences and Research, Sharda University, Greater Noida 201310 Uttar Pradesh, India., Dholpuria S; Department of Life Sciences, J.C. Bose University of Science and Technology, YMCA, Faridabad 121006 Haryana, India., Ruokolainen J; Department of Applied Physics, School of Science, Aalto University, Espoo 00076, Finland., Kesari KK; Department of Bioproducts and Biosystems, School of Chemical Engineering, Aalto University, Espoo 00076, Finland.; Department of Applied Physics, School of Science, Aalto University, Espoo 00076, Finland., Mishra M; Department of Life Science, National Institute of Technology, Rourkela 769008 Odisha, India., Gupta PK; Department of Life Sciences, Sharda School of Basic Sciences and Research, Sharda University, Greater Noida 201310 Uttar Pradesh, India.; Department of Biotechnology, Graphic Era Deemed to Be University, Dehradun 248002 Uttarakhand, India.; Faculty of Health and Life Sciences, INTI International University, Nilai 71800, Malaysia.
المصدر: ACS applied bio materials [ACS Appl Bio Mater] 2023 Mar 20; Vol. 6 (3), pp. 1122-1132. Date of Electronic Publication: 2023 Feb 09.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: ACS Publications Country of Publication: United States NLM ID: 101729147 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2576-6422 (Electronic) Linking ISSN: 25766422 NLM ISO Abbreviation: ACS Appl Bio Mater Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Washington, DC : ACS Publications, [2018]-
مواضيع طبية MeSH: Drosophila melanogaster*/genetics , Nanocomposites*/chemistry, Mice ; Animals ; Drug Delivery Systems ; Tissue Engineering
مستخلص: Nanocomposites have significantly contributed to biomedical science due to less aggregation behavior and enhanced physicochemical properties. This study synthesized a MnFe 2 O 4 @poly( t BGE-alt-PA) nanocomposite for the first time and physicochemically characterized it. The obtained hybrid nanomaterial was tested in vivo for its toxicological properties before use in drug delivery, tissue engineering fields, and environmental applications. The composite was biocompatible with mouse fibroblast cells and hemocompatible with 2% RBC suspension. This nanocomposite was tested on Drosophila melanogaster due to its small size, well-sequenced genome, and low cost of testing. The larvae's crawling speed and direction were measured after feeding. No abnormal path and altered crawling pattern indicated the nonappearance of abnormal neurological disorder in the larva. The gut organ toxicity was further analyzed using DAPI and DCFH-DA dye to examine the structural anomalies. No apoptosis and necrosis were observed in the gut of the fruit fly. Next, adult flies were examined for phenotypic anomalies after their pupal phases emerged. No defects in the phenotypes, including the eye, wings, abdomen, and bristles, were found in our study. Based on these observations, the MnFe 2 O 4 @poly( t BGE-alt-PA) composite may be used for various biomedical and environmental applications.
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فهرسة مساهمة: Keywords: Drosophila melanogaster; biocompatible; genotoxicity; nanocomposite; toxicity assessment
تواريخ الأحداث: Date Created: 20230209 Date Completed: 20230321 Latest Revision: 20230325
رمز التحديث: 20230327
مُعرف محوري في PubMed: PMC10031559
DOI: 10.1021/acsabm.2c00983
PMID: 36757355
قاعدة البيانات: MEDLINE
الوصف
تدمد:2576-6422
DOI:10.1021/acsabm.2c00983